Protein Alignment eEF2 and Efl1

DIOPT Version :9

• Sequence 1: NP_525105.2
• Gene: eEF2 / 35422
• FlyBaseID: FBgn0000559
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001101004.1
• Gene: Efl1 / 308789
• RGDID: 1306521
• Length: 1127
• Species: Rattus norvegicus
• Alignment Length: 1128
• Identity: 325/1128 - (28%)
• Similarity: 511/1128 - (45%)
• Gaps: 319/1128 - (28%)

  Fly     1 MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQE 65
            ||...:|::..|.....||||:.|:|||||||:||.|.|:|..|||:...||:.|:.|:|:|||.
  Rat     1 MVLSGLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQV 65

  Fly    66 RCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGAL 130
            |.||:||:|||:::....::                :|||||||||||||||||:.|:|:.||.:
  Rat    66 RGITMKSSAISLHYAEGSEE----------------YLINLIDSPGHVDFSSEVSTAVRICDGCI 114

  Fly   131 VVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIAT 195
            :|||.|.|||.||:.|||||..|.|:|:|.:||:||.::||:...:|.|...:.|:..:|.:..|
  Rat   115 IVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILGQINALTGT 179

  Fly   196 ---------------------YNDDGGPM------------GEVRVDPSKGSVGFGSGLHGWAFT 227
                                 :::.|..:            .::...|.:|:|.|.|.:.||.|.
  Rat   180 LFTSKVLEERAERETESQAKSHSEQGDQVYDWSTGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFG 244

  Fly   228 LKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQKEADNKRS-FCMYILDPIYKVFDAIM 291
            ::.|:.:||:|..|....|:..|||:.:.|.|.||..|..:|..|:. |...||:.|:.::||::
  Rat   245 IEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVL 309

  Fly   292 NYKKEEIGTLLEKIGVTL-KHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRM 355
            ...||::..::..:|:.: ..|.:..|.|..:..:...|||...|:|.|:...||||:.....|:
  Rat   310 KKDKEKVDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDMTSERV 374

  Fly   356 EML-------YEG-PHDDEA-AIAVKSC--DPDGPLMMYISKMV--------------------- 388
            |.|       :|. |.:.:| ..|...|  :...|:::::|||.
  Rat   375 EKLMCTGSQTFESLPLETQALKAAFMKCGSEDTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMA 439

  Fly   389 ------------------------PTSDKG----------------------------------R 395
                                    ||.|.|                                  .
  Rat   440 QRRERARQRHAEKLAAAQGQAPQGPTQDGGALETSPQEDEPRGEEPDMTSVSRQPAPQEESSQEA 504

  Fly   396 FYAFGRVFAGKVATGQKCRIMGPNYTP------------GKKEDLYEK------AIQRTILMMGR 442
            |.||.|||:|....|:|..::||.|:|            ...|||...      .::...|:|||
  Rat   505 FIAFARVFSGVARRGKKIFVLGPKYSPVDFLQRVPQGFSAPLEDLPPVPHMACCTLENLYLLMGR 569

  Fly   443 YVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLV 507
            .:|.:|:||.||:.|:.|:...::|:.|:.:.........:.|..:|:||||||||:|:::|:||
  Rat   570 ELEDLEEVPPGNVLGIGGLQDSVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLV 634

  Fly   508 EGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSE- 571
            :|:|.|.::||.||.:|:|:|||::..|||:||:.||.||.|..|.|.:..|:|::.:|||:::
  Rat   635 KGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKP 699

  Fly   572 -----------------------------------ESDQMCLSKSPNKHNRLLMKALPMPDGLPE 601
                                               :||.:....:|||...|.::|:|:|:.:..
  Rat   700 PKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGILVDSDGLITIPTPNKLATLSVRAIPLPEEVTR 764

  Fly   602 DI-DNGDV--------SAKDEFKARARYLSEKYDYDVTEAR-----------------KIWCFGP 640
            .: :|.|:        |:.:|.: ..:.:.:|....:.|.:                 :||.|||
  Rat   765 ILEENSDLIRSMELLTSSLNEGR-NTQAIHQKTQEKIWEFKGKLEKHLTGRKWRNTVDQIWSFGP 828

  Fly   641 DGTGPNFILDC----------------TKSVQYLNEIKDSVVAGFQWASKEGILADENLRGVRFN 689
            ...|||.::..                :|......:..:|:|:|||.|:..|.:.:|.|.||.|.
  Rat   829 RKCGPNILVSRSEDFQSSVWSGPAGRESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFV 893

  Fly   690 IYDVTLH-------ADAIHRG-------------------------------------------- 703
            :....|:       :|...:|
  Rat   894 LEKWELNKCAEPGASDKQSQGQCDLTGEGQEKSKTCPVGDENQEQQDGYSEPFEETSQKGDSPVI 958

  Fly   704 ------GGQIIPTTRR-CLYAAAITAKP-RLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEEN 760
                  .||:|.|.:. |.|  |:..|| |||..:|.|:|......:|.:|.||::|.|.|.:|.
  Rat   959 DCYGPFSGQLIATMKEACRY--ALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEE 1021

  Fly   761 QVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDP--------------- 810
            ...||.||::||.|||.|||||..::|..|.|.|.||.||.||:|:|.||
  Rat  1022 MKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGE 1086

  Fly   811 ---SEPSSKPYAIVQDTRKRKGL 830
               ||..::.|  :...||||||
  Rat  1087 KADSENQARKY--MNAVRKRKGL 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	325/1128 (29%)
		EF2	20..236	CDD:206672	94/248 (38%)
		EF2_snRNP_like_II	380..474	CDD:293901	37/190 (19%)
		EF2_snRNP_III	489..560	CDD:293918	37/70 (53%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	55/308 (18%)
		eEF2_snRNP_like_C	728..807	CDD:239763	36/78 (46%)
Efl1	NP_001101004.1	PTZ00416	1..1110	CDD:240409	325/1128 (29%)
		EF2	20..253	CDD:206672	94/248 (38%)
		EF2_II	505..600	CDD:293913	30/94 (32%)
		EF2_snRNP_III	616..687	CDD:293918	37/70 (53%)
		aeEF2_snRNP_like_IV	687..993	CDD:238839	55/308 (18%)
		eEF2_snRNP_like_C	990..1068	CDD:239763	36/77 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820