DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and eftu-2

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_498308.1	Gene:	eftu-2 / 175851	WormBaseID:	WBGene00001166	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	856	Identity:	303/856 - (35%)
Similarity:	499/856 - (58%)	Gaps:	47/856 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKA-GIIAGAKAGETRFTDTRKDEQERCITIKSTAI 75
            |||....:||:::..|:.|||:|..|.|:.:. .....|:..:.||||....|::|..:|||..:
Worm   125 LMDCPHIMRNVAIAGHLHHGKTTFLDCLMEQTHPEFYRAEDADARFTDILFIEKQRGCSIKSQPV 189

  Fly    76 SMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVC 140
            |            |...|.|.   |.:|:|:||:||||:||.|:||:.|:.||.:|:||...||.
Worm   190 S------------IVAQDSRS---KSYLLNIIDTPGHVNFSDEMTASYRLADGVVVMVDAHEGVM 239

  Fly   141 VQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGE 205
            :.||..:|.||.||:...|.::|:||.||||:|...:.|...:.|::.||.|::|:.::..|:
Worm   240 MNTERAIRHAIQERLAVTLCISKIDRLLLELKLPPADAYFKLRLIIDQVNNILSTFAEEDVPV-- 302

  Fly   206 VRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKF--KIDVVKLMNRLWGENFFNAKTKKWQKQKE 268
              :.|..|:|.|.||.:...|:|..||.:|:::.  ..:..:...||||:.:|..||:|:.|:..
Worm   303 --LSPLNGNVIFSSGRYNVCFSLLSFSNIYAKQHGDSFNSKEFARRLWGDIYFEKKTRKFVKKSP 365

  Fly   269 A-DNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPA 332
            : |..|:|..:||:|:||:|..::......:..::.::|:.|..|::..:.:.|:..:.:.:...
Worm   366 SHDAPRTFVQFILEPMYKIFSQVVGDVDTCLPDVMAELGIRLSKEEQKMNVRPLIALICKRFFGD 430

  Fly   333 GEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFY 397
            ..|.:.::..::.||:...|.::|..|.||.|.:.|..::.|:.:||||::.:|..|..|..:|:
Worm   431 FSAFVDLVVQNIKSPLENAKTKIEQTYLGPADSQLAQEMQKCNAEGPLMVHTTKNYPVDDATQFH 495

  Fly   398 AFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVD 462
            .||||.:|.:......|::|.||:...:||.....:.|..:.:..|...:..||:|....:.|:|
Worm   496 VFGRVMSGTLEANTDVRVLGENYSIQDEEDCRRMTVGRLFVRVASYQIEVSRVPAGCWVLIEGID 560

  Fly   463 QFLVKTGTITTF---KDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCII 524
            |.:|||.||...   :|.:..:.:||:....|::||||.||::|||:::||:::.||.|::...:
Worm   561 QPIVKTATIAELGYEEDVYIFRPLKFNTRSCVKLAVEPINPSELPKMLDGLRKVNKSYPLLTTRV 625

  Fly   525 EESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLL 589
            ||||||::.|.||.:::..:.|:.:..:.|.:|.:||||::.|||.|.|...|.:::|||.|::.
Worm   626 EESGEHVLLGTGEFYMDCVMHDMRKVFSEIDIKVADPVVTFNETVIETSTLKCFAETPNKKNKIT 690

  Fly   590 MKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKS 654
            |.|.|:...|.|||:|..|......:....:...||::|:..||.||.||||.||||.:||.|..
Worm   691 MMAEPLEKQLDEDIENEVVQIGWNRRRLGEFFQTKYNWDLLAARSIWAFGPDTTGPNILLDDTLP 755

  Fly   655 VQ----YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCL 715
            .:    .|:.:::|:|.|||||::||.|.:|.:|.|:|.:.|..:..:.::|||||:|||.|||.
Worm   756 SEVDKHLLSTVRESLVQGFQWATREGPLCEEPIRQVKFKLLDAAIATEPLYRGGGQMIPTARRCA 820

  Fly   716 YAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESF 780
            |:|.:.|.||||||.|..|:..|...|..:|.||.:|||||..:..:.|:||:.:.||:||.:||
Worm   821 YSAFLMATPRLMEPYYTVEVVAPADCVAAVYTVLAKRRGHVTTDAPMPGSPMYTISAYIPVMDSF 885

  Fly   781 GFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPS--------------SKPYAIVQDTRKRKGLK 831
            ||..|||.:|.||||....|.|||::||||.:.|              ::.:.|  .||:||||.
Worm   886 GFETDLRIHTQGQAFCMSAFHHWQLVPGDPLDKSIVIKTLDVQPTPHLAREFMI--KTRRRKGLS 948

  Fly   832 EGLPDLSQYLD 842
            |.: .::::.|
Worm   949 EDV-SVNKFFD 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	303/856 (35%)
		EF2	20..236	CDD:206672	78/216 (36%)
		EF2_snRNP_like_II	380..474	CDD:293901	30/93 (32%)
		EF2_snRNP_III	489..560	CDD:293918	27/70 (39%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	77/175 (44%)
		eEF2_snRNP_like_C	728..807	CDD:239763	37/78 (47%)
eftu-2	NP_498308.1	EFTUD2	4..113	CDD:374287
eftu-2	NP_498308.1	FusA	125..958	CDD:357662	302/854 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720