DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and gfm-1

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_496787.1	Gene:	gfm-1 / 174956	WormBaseID:	WBGene00009246	Length:	750	Species:	Caenorhabditis elegans

Alignment Length:	869	Identity:	222/869 - (25%)
Similarity:	342/869 - (39%)	Gaps:	236/869 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IRNMSVIAHVDHGKSTLTDSLVSKAGIIAGA-------KAGETR-FTDTRKDEQERCITIKSTAI 75
            |||:.:.||:|.||:|:|:.::..||.|...       ..|.|. |.|.   |::|.|||:|.|
Worm    44 IRNIGISAHIDSGKTTVTERILYYAGRIDSMHEVRGKDDVGATMDFMDL---ERQRGITIQSAA- 104

  Fly    76 SMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVC 140
                          |:.|..     |..||:||:||||||:.||..||||.|||::|:..|.||.
Worm   105 --------------TYVDWH-----GTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCGVGGVQ 150

  Fly   141 VQTETVLRQAIAERIKPILFMNKMDR--------------------ALLELQLDAEELYQTFQRI 185
            .||.||.||.....:..|.|:|||||                    ||:.|.:..:   ..|..|
Worm   151 SQTFTVNRQLARYNVPFICFVNKMDRNGATPLKALDGLRNKLNHNAALIHLPIGKD---SNFNGI 212

  Fly   186 VENVNVIIATYNDDGGPMGEVRVD--PSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMN 248
            |:.|......|..:||.:  ||.|  |.               .|:..:|...::. |:.:..::
Worm   213 VDLVEGHALYYEGEGGLI--VRKDEIPK---------------DLRVEAEDRRQEL-IEHIANVD 259

  Fly   249 RLWGENFFNAKTKKWQKQKEADN----KRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTL 309
            ...||.|.|.:|...|:..||..    ||:|.     |:..             |:.|:..||
Worm   260 ETLGEMFLNDQTPNVQQIHEAIRRTVVKRAFV-----PVLS-------------GSALKNKGV-- 304

  Fly   310 KHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSC 374
                     :.::.:|:: :||.            ||.||   .|..:..|...|::..|.....
Worm   305 ---------QTMINSVVK-YLPD------------PSEVV---NRATVKTETTGDEKGIILSPKR 344

  Fly   375 DPDGPLMMYISKMVPTSDKGRF--YAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTI 437
            :.|.|.:....|:    :.|::  ..:.||:.|:::.|.         |.....|..:..:||.:
Worm   345 NNDKPFVGLAFKL----EAGKYGQLTYFRVYQGQLSKGD---------TVYASRDGRKVRVQRLV 396

  Fly   438 LMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSV---SPVVRVAVEPKN 499
            .|....:|.|....:|:||...|:|   ..:|  .||....|:.....|:   .||:.:|::|.|
Worm   397 RMHAADMEEITTAYAGDICATFGLD---CHSG--ETFSTDQNLAPHCESMHIPEPVISMAIKPVN 456

  Fly   500 PADLPKLVEGLKRLAKSDPMVQC-IIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVV 563
            ..|....::.|.|..|.||..:. ..:|:.|.|::|.|||||||..:.::.::.| |::...|.|
Worm   457 RKDADNFIKALTRFTKEDPTFRREYNQEAKETIVSGMGELHLEIYAQRMKSEYNC-PVELGKPTV 520

  Fly   564 SYRETVSEESDQMCLSKSPNKHNRLLMKAL----------PMPDGLPEDIDNGDVSAKDEFKARA 618
            :|||         ||. ||.|.:....|..          .:.|.||.| .|..|...||
Worm   521 AYRE---------CLG-SPYKFHFRHKKQTGGQGQFGEIEGVIDPLPSD-RNTVVEFSDE----- 569

  Fly   619 RYLSEKYDYDVTEARKIWCFG---PDGTGPNFILDCTKSVQYLNEIKDSVVAGFQWASKEGILAD 680
                              .||   |....|           .|.:..|::||       ||.|..
Worm   570 ------------------TFGNNIPKNLFP-----------ALKKGLDAIVA-------EGPLIK 598

  Fly   681 ENLRGVRFNIYDVTLHA-DAIHRGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGG 744
            ..:.|:...|.|.:.|| |:....   :|.|.:..:..:...|...|:||:...|...|....|.
Worm   599 SRIAGIHVRIQDGSTHAVDSTEIA---MINTMQNMMRESFEKANWLLLEPIMKVEATVPTEFQGN 660

  Fly   745 IYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQA--------------- 794
            :...|.:|...:...:...|....:.:|  |:::.||:|::|||.|.|:.
Worm   661 VVTSLTQRNALITTTDSTEGYATVICEA--PLSDMFGYTSELRSLTEGKGEFSMEYSRYAPTTLE 723

  Fly   795 FPQCVFDHWQVLPG--DPSEPSSK 816
            ....|...|:.|.|  ||:|...|
Worm   724 AQDRVQAEWRQLHGIADPNEKGKK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	222/869 (26%)
		EF2	20..236	CDD:206672	78/245 (32%)
		EF2_snRNP_like_II	380..474	CDD:293901	19/95 (20%)
		EF2_snRNP_III	489..560	CDD:293918	24/71 (34%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	42/185 (23%)
		eEF2_snRNP_like_C	728..807	CDD:239763	20/93 (22%)
gfm-1	NP_496787.1	EF-G	46..318	CDD:206673	97/357 (27%)
		PRK12740	50..730	CDD:237186	212/844 (25%)
		mtEFG1_II_like	350..430	CDD:293908	21/97 (22%)
		EFG_III	444..518	CDD:293919	24/74 (32%)
		EFG_mtEFG1_IV	522..639	CDD:238715	36/171 (21%)
		mtEFG1_C	644..721	CDD:239764	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810