DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and eef-2

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001369996.1	Gene:	eef-2 / 172743	WormBaseID:	WBGene00001167	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	852	Identity:	684/852 - (80%)
Similarity:	761/852 - (89%)	Gaps:	8/852 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQE 65
            ||||||||||.|||:|||||||||||||||||||||||||||||||||:||||||||||||||||
Worm     1 MVNFTVDEIRALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRFTDTRKDEQE 65

  Fly    66 RCITIKSTAISMYFEVEEKDLVFI--------THPDQREKECKGFLINLIDSPGHVDFSSEVTAA 122
            |||||||||||::||:|:|||.|:        ...|.::::..||||||||||||||||||||||
Worm    66 RCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAA 130

  Fly   123 LRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVE 187
            |||||||||||||||||||||||||||||||||||:|||||||||||||||.||||:||||||||
Worm   131 LRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELFQTFQRIVE 195

  Fly   188 NVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMNRLWG 252
            |:|||||||.||.||||.:.||||.|:|||||||||||||||||:|||:.||.:.|.|||..|||
Worm   196 NINVIIATYGDDDGPMGPIMVDPSIGNVGFGSGLHGWAFTLKQFAEMYAGKFGVQVDKLMKNLWG 260

  Fly   253 ENFFNAKTKKWQKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKD 317
            :.||:.|||||...:..::||.||.::||||:.||||:||.||::...|:||:|:.|.:::||.:
Worm   261 DRFFDLKTKKWSSTQTDESKRGFCQFVLDPIFMVFDAVMNIKKDKTAALVEKLGIKLANDEKDLE 325

  Fly   318 GKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMM 382
            ||.|:|..||.|||||:.:|||||.||||||.|||||||||||||||||||:|:|:|||:|||||
Worm   326 GKPLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMEMLYEGPHDDEAAVAIKTCDPNGPLMM 390

  Fly   383 YISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAI 447
            |||||||||||||||||||||:||||||.|.||.||||.||||||||||.||||||||||::|.|
Worm   391 YISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRFIEPI 455

  Fly   448 EDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKR 512
            ||:|||||.|||||||:|||.|||||:||||||:|||||||||||||||.|||||||||||||||
Worm   456 EDIPSGNIAGLVGVDQYLVKGGTITTYKDAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKR 520

  Fly   513 LAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMC 577
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||..||:|:|
Worm   521 LAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVQSESNQIC 585

  Fly   578 LSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDG 642
            |||||||||||...|.||||||.:||:.|.|:|:|||||||:.|:|||:||||||||||||||||
Worm   586 LSKSPNKHNRLHCTAQPMPDGLADDIEGGTVNARDEFKARAKILAEKYEYDVTEARKIWCFGPDG 650

  Fly   643 TGPNFILDCTKSVQYLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQI 707
            ||||.::|.||.||||||||||||||||||::||:|:|||:||||||::||||||||||||||||
Worm   651 TGPNLLMDVTKGVQYLNEIKDSVVAGFQWATREGVLSDENMRGVRFNVHDVTLHADAIHRGGGQI 715

  Fly   708 IPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKA 772
            |||.||..||:.:||:|||:|||||.||||||.|||||||||||||||||||:||.|||||||||
Worm   716 IPTARRVFYASVLTAEPRLLEPVYLVEIQCPEAAVGGIYGVLNRRRGHVFEESQVTGTPMFVVKA 780

  Fly   773 YLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKEGLPDL 837
            ||||||||||||||||||||||||||||||||||||||.|..:||..||.|||||||||||:|.|
Worm   781 YLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPLEAGTKPNQIVLDTRKRKGLKEGVPAL 845

  Fly   838 SQYLDKL 844
            ..||||:
Worm   846 DNYLDKM 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	683/850 (80%)
		EF2	20..236	CDD:206672	186/223 (83%)
		EF2_snRNP_like_II	380..474	CDD:293901	80/93 (86%)
		EF2_snRNP_III	489..560	CDD:293918	68/70 (97%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	132/171 (77%)
		eEF2_snRNP_like_C	728..807	CDD:239763	74/78 (95%)
eef-2	NP_001369996.1	PTZ00416	1..852	CDD:240409	683/850 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157620
Domainoid	1	1.000	503	1.000	Domainoid score	I171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134867
Inparanoid	1	1.050	1404	1.000	Inparanoid score	I54
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62214
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0002412
OrthoInspector	1	1.000	-	-		oto18099
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R367
SonicParanoid	1	1.000	-	-		X1605
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940