DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and Eef2

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_031933.1	Gene:	Eef2 / 13629	MGIID:	95288	Length:	858	Species:	Mus musculus

Alignment Length:	862	Identity:	677/862 - (78%)
Similarity:	747/862 - (86%)	Gaps:	22/862 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQE 65
            |||||||:||.:||||.|||||||||||||||||||||||.||||||.|:|||||||||||||||
Mouse     1 MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQE 65

  Fly    66 RCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGAL 130
            |||||||||||:::|:.|.||.||    ::.|:..||||||||||||||||||||||||||||||
Mouse    66 RCITIKSTAISLFYELSENDLNFI----KQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGAL 126

  Fly   131 VVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIAT 195
            |||||||||||||||||||||||||||:|.|||||||||||||:.||||||||||||||||||:|
Mouse   127 VVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIIST 191

  Fly   196 YND-DGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKI-------------DVVKL 246
            |.: :.||||.:.:||..|:|||||||||||||||||:|||..||..             .|..:
Mouse   192 YGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDM 256

  Fly   247 MNRLWGENFFNAKTKKWQKQKEA-DNK---RSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGV 307
            |.:|||:.:|:....|:.|...: |.|   |:||..|||||:||||||||::|||...|:||:.:
Mouse   257 MKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAIMNFRKEETAKLIEKLDI 321

  Fly   308 TLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVK 372
            .|..|||||:||.|||.|||.|||||:||||||.|||||||.|||||.|:|||||.|||||:.:|
Mouse   322 KLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIK 386

  Fly   373 SCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTI 437
            ||||.||||||||||||||||||||||||||:|.|:||.|.||||||||||||||||.|.|||||
Mouse   387 SCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGVVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTI 451

  Fly   438 LMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSVSPVVRVAVEPKNPAD 502
            ||||||||.|||||.|||.||||||||||||||||||:.||||:|||||||||||||||.|||||
Mouse   452 LMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPAD 516

  Fly   503 LPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRE 567
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse   517 LPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRE 581

  Fly   568 TVSEESDQMCLSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEA 632
            ||||||:.:||||||||||||.|||.|.||||.||||.|:|||:.|.|||||||:|||::||.||
Mouse   582 TVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKARARYLAEKYEWDVAEA 646

  Fly   633 RKIWCFGPDGTGPNFILDCTKSVQYLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHA 697
            ||||||||||||||.:.|.||.||||||||||||||||||:|||.|.:||:|||||:::||||||
Mouse   647 RKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHA 711

  Fly   698 DAIHRGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQV 762
            |||||||||||||.||||||:.:||:||||||:||.||||||..||||||||||:|||||||:||
Mouse   712 DAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQV 776

  Fly   763 VGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKR 827
            .|||||||||||||||||||||||||||||||||||||||||:|||||.:.||:|..:|.:||||
Mouse   777 AGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKR 841

  Fly   828 KGLKEGLPDLSQYLDKL 844
            ||||||:|.|..:||||
Mouse   842 KGLKEGIPALDNFLDKL 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	675/860 (78%)
		EF2	20..236	CDD:206672	178/216 (82%)
		EF2_snRNP_like_II	380..474	CDD:293901	83/93 (89%)
		EF2_snRNP_III	489..560	CDD:293918	68/70 (97%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	136/171 (80%)
		eEF2_snRNP_like_C	728..807	CDD:239763	70/78 (90%)
Eef2	NP_031933.1	PTZ00416	1..858	CDD:240409	675/860 (78%)
		EF2	20..233	CDD:206672	178/216 (82%)
		EF2_snRNP_like_II	394..488	CDD:293901	83/93 (89%)
		EF2_snRNP_III	503..574	CDD:293918	68/70 (97%)
		aeEF2_snRNP_like_IV	574..746	CDD:238839	136/171 (80%)
		eEF2_snRNP_like_C	742..821	CDD:239763	70/78 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833694
Domainoid	1	1.000	467	1.000	Domainoid score	I463
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134867
Inparanoid	1	1.050	1361	1.000	Inparanoid score	I133
Isobase	1	0.950	-	0	Normalized mean entropy	S111
OMA	1	1.010	-	-		QHG62214
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0002412
OrthoInspector	1	1.000	-	-		oto94943
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R367
SonicParanoid	1	1.000	-	-		X1605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750