DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and Gfm1

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_446077.2	Gene:	Gfm1 / 114017	RGDID:	631396	Length:	751	Species:	Rattus norvegicus

Alignment Length:	867	Identity:	215/867 - (24%)
Similarity:	348/867 - (40%)	Gaps:	212/867 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDEIRGLMDKKRN----------------IRNMSVIAHVDHGKSTLTDSLVSKAGIIA-----GA 49
            |..|.|...|:.|                |||:.:.||:|.||:|||:.::...|.||     ..
  Rat    18 VPAILGWQGKQANWKTYRWCSSGSIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIATMHEVKG 82

  Fly    50 KAGETRFTDTRKDEQERCITIKSTA-ISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHV 113
            |.|.....|:.:.|::|.|||:|.| .:|:.:|.                     ||:||:||||
  Rat    83 KDGVGAVMDSMELERQRGITIQSAATYTMWRDVN---------------------INIIDTPGHV 126

  Fly   114 DFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDR------------ 166
            ||:.||..||||.|||::|:..|.||..||.||.||.....:..:.|:||:||
  Rat   127 DFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVSRQMKRYNVPFLTFINKLDRMGSNPARALQQM 191

  Fly   167 --------ALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHG 223
                    |.:::.:..|   ..|:.|::.:......::.|.|.:  ||.|.....:...:..|
  Rat   192 RSKLNHNAAFVQIPIGLE---GDFKGIIDLIEERAIYFDGDFGQI--VRYDEIPADLRAAAADH- 250

  Fly   224 WAFTLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQK----EADNKRSFCMYILDPIY 284
                         .:..|:.|...:...||.|...|.......|    .|...|||     .|::
  Rat   251 -------------RQELIECVANSDEQLGELFLEEKIPSVSDLKLAIRRATLSRSF-----TPVF 297

  Fly   285 KVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVV 349
                         :|:.|:..||                          :.||..:...||:|..
  Rat   298 -------------LGSALKNKGV--------------------------QPLLDAVLEFLPNPSE 323

  Fly   350 AQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRF--YAFGRVFAGKVATGQK 412
            .|.|.:....:....::..:..|. |...|.:....|:    :.|||  ..:.|.:.|::..|..
  Rat   324 VQNYALLNQNDSKEKNKILMNPKR-DDSHPFVGLAFKL----EAGRFGQLTYVRNYQGELKKGST 383

  Fly   413 CRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDA 477
            ..    |...|||     ..:||.:.|....:|.:|:|.:|:||.|.|:|   ..:|...|.||.
  Rat   384 IY----NTRTGKK-----VRVQRLVRMHADMMEDVEEVYAGDICALFGID---CASGDTFTNKDN 436

  Fly   478 HNMKVMKFSV-SPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIE-ESGEHIIAGAGELHL 540
            .::.:....| .||:.||::|.|..||.|..:|:.|..:.||..:...: ||.|.|::|.|||||
  Rat   437 SDLSMESIHVPDPVISVAMKPSNKNDLEKFSKGIARFTREDPTFKVHFDTESKETIVSGMGELHL 501

  Fly   541 EICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMPDGLPEDIDN 605
            ||..:.:|.::.| |.....|.|::||||:                      .|:|........:
  Rat   502 EIYAQRMEREYGC-PCITGKPKVAFRETVT----------------------APVPFDFTHKKQS 543

  Fly   606 GDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQYLNEIKDSVVAGFQ 670
            |......:.......|:.: ||...|      |..:..|.|          ...:...:|..||.
  Rat   544 GGAGQYGKVIGVLEPLAPE-DYTKLE------FSDETFGAN----------VPKQFVPAVEKGFL 591

  Fly   671 WASKEGILADENLRGVRFNIYDVTLH-ADA-----IHRGGGQIIPTTRRCLYAAAITAKPRLMEP 729
            .|.::|.|:...|.|:||.:.|...| .|:     |..|.|.:    ::.|.:|.:.    ::||
  Rat   592 DACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGAL----KQALASATLC----IIEP 648

  Fly   730 VYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQA 794
            :...|:..|....|.::..:|||.|.:..::.:  ...|.:.|.:|:|..||::.:|||.|.|:.
  Rat   649 IMSVEVIAPNEFQGAVFAGINRRHGVITGQDGI--EDYFTLYADVPLNNMFGYSTELRSCTEGKG 711

  Fly   795 FPQCVFDHWQVLPGDPSEPSSK 816
            .....::.:|     |..||::
  Rat   712 EYTMEYNRYQ-----PCSPSTQ 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	215/867 (25%)
		EF2	20..236	CDD:206672	69/241 (29%)
		EF2_snRNP_like_II	380..474	CDD:293901	24/95 (25%)
		EF2_snRNP_III	489..560	CDD:293918	28/71 (39%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	36/177 (20%)
		eEF2_snRNP_like_C	728..807	CDD:239763	21/78 (27%)
Gfm1	NP_446077.2	PRK12740	53..732	CDD:237186	207/832 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810