DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul4a

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_666319.2	Gene:	Cul4a / 99375	MGIID:	1914487	Length:	759	Species:	Mus musculus

Alignment Length:	761	Identity:	191/761 - (25%)
Similarity:	366/761 - (48%)	Gaps:	81/761 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEML--- 73
            |.|.:|....:::.:.|.:..:: ...:..|..||..:..|   .||.:.:...|.|||..:
Mouse    61 DTWRKLHEAVKAIQSSTSIRYNL-EELYQAVENLCSHKVSP---TLYKQLRQVCEDHVQAQILPF 121

  Fly    74 ----AKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFY 134
                ...||             .|::....|.::.:.:..:..::::|::.::.:..:..:
Mouse   122 REDSLDSVL-------------FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS---- 169

  Fly   135 GNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVI 197
                        |.::||:::|.::|  ..:.|:.:..||..|..:|:...        :...::
Mouse   170 ------------IWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEA--------VDRSLL 214

  Fly   198 HSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRA 262
            .|.:.:     ...|::|::.||...||.:...|..|..:|:....|.||:..|.:.||.|:.|.
Mouse   215 RSLLSM-----LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRV 274

  Fly   263 QKFLHVSSLPKLRKECEEKFINDRLGFIYSECRE-MVSEERRQDLRNMYVVLKPIPDNLKSELIT 326
            ..:|..|:...|....|::.:.:.|..|..:..| ::.|.|..||..||.:...:... :..|:.
Mouse   275 ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEHLLDENRVPDLTQMYQLFSRVKGG-QHALLQ 338

  Fly   327 TFLDHIKSEGLQ-TVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVIN 390
            .:.::||:.|.. .::..|.:::    |:::|....|...::...|:.:..|::.:.::..:.||
Mouse   339 HWSEYIKTFGTTIVINPEKDKDM----VQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFIN 399

  Fly   391 RRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAK 453
            :||.     :.||.:||:.|:.|:  ..:..:.|:::.|...:.:|::|..|||::.||.:.|||
Mouse   400 KRPN-----KPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAK 459

  Fly   454 RLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLA 518
            ||:..:|.|:|||:.|:::||..||..||:||..||.|:.:|.|:...|..|:::.:....|:|.
Mouse   460 RLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLT 524

  Fly   519 IKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELK--LSHLKK 581
            :.:|..|.||..:...:  .:|.|..:..::|:.:|....|||||.|...:.|..||  ....||
Mouse   525 VNILTMGYWPTYTPMEV--HLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKK 587

  Fly   582 SYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESK----LLNASSENLAG 642
            .:.|::  :|..::|:|...|..|..||:....:.|...::.:|.:...|    :.:...:.:..
Mouse   588 EFQVSL--FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVED 650

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            ..:...|.|:.:|..:.||:....|||.:|...|...|.:||:..:.||||||||.||.|.||.|
Mouse   651 GDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            :.|:.:..|....|  ..:||.:|||||:.|:||..:|.::|.|:|
Mouse   716 VSELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	143/618 (23%)
		CULLIN	436..575	CDD:214545	49/138 (36%)
		Cullin_Nedd8	680..745	CDD:214883	30/64 (47%)
Cul4a	NP_666319.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Cullin	65..659	CDD:279260	146/653 (22%)
		CULLIN	442..582	CDD:214545	51/141 (36%)
		Cullin_Nedd8	688..753	CDD:214883	31/66 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830