DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul2 and CUL3

DIOPT Version :9

Sequence 1:NP_610117.1 Gene:Cul2 / 35420 FlyBaseID:FBgn0032956 Length:753 Species:Drosophila melanogaster
Sequence 2:NP_011517.1 Gene:CUL3 / 852886 SGDID:S000003235 Length:744 Species:Saccharomyces cerevisiae


Alignment Length:803 Identity:178/803 - (22%)
Similarity:358/803 - (44%) Gaps:139/803 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEMLA 74
            |.:.|..::...:.:.:....:.| :...:..:||:.:.:..|:   ||...|.:|   :|::..
Yeast    22 FEESWETVKYAIDHIYSDDMADLS-FEQVYKTIYTIVLNKKGPI---LYNRLKDYL---IQKLAL 79

  Fly    75 KKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSS 139
            .:..|..:.:|..   :.|......|.......|....|.:|:::.:.|..:.            
Yeast    80 LRETIVKDNTHDY---EFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRC------------ 129

  Fly   140 DAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASN-GTLDHHRV---QIINGVIHSF 200
                 ||:.::.||::|:.:::..||.|:..::..|  :|..| |::|....   :::.|::.:.
Yeast   130 -----MEVYDMCLDLFRIEILQKCSSSLISALISDI--ERIRNLGSVDSEHTSLWKVLIGMMETL 187

  Fly   201 VEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKL--LHRCSVSEYMQEVIRILEYESRRAQ 263
            .:.:|       ..:...||..::.|:..||    ||.  :...:..|.::::.::.::||....
Yeast   188 HDNRD-------SFFLTDFEPVLISATEEYY----NKAIDIELLTPIESLEKIRKLRQFESMLDS 241

  Fly   264 KFLHVSSLPKLRKECEEKFINDRL----------------GFIYSECREMVSEERRQDLRNMYVV 312
            .||:|.|..||:...|...|..:|                |.:..|..::.|||:       |.|
Yeast   242 SFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEEK-------YRV 299

  Fly   313 LKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVH---HKYQE--------- 365
              .:.:::||.:....::...:||    :..||:|. |.:...:::::   |.:.|         
Yeast   300 --TVIESIKSYINKNAINIPFNEG----NRKKGQNA-ITWSSEIVELYRSQHSFLESIDFGSVRL 357

  Fly   366 ----------LIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTCE 420
                      ::.|||   |::.|                ::....:||::.|.|..:|::|..:
Yeast   358 NNLTGDVSNAILGDVF---SMYFS----------------KEGALPSEYLSTYVDHCMKRTKEKD 403

  Fly   421 AE---IDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFT 482
            ||   |.|.|.::..:...:.:||:::|.|.:.|::||:.::| .::.|:.|:..:|:..|..||
Yeast   404 AEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRS-LVEIEKWMVQMIKKVLGTFFT 467

  Fly   483 NKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIP--FAVPQEFEK 545
            :||..|..|||:|.::...|. |...::::. ::.|.:||...:||..||..|.  .::|....:
Yeast   468 SKLEIMLRDISLSSEMYQAFQ-HSTINSIEY-LSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQ 530

  Fly   546 SIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQ 610
            .:..||.||...:..|.|.|.||:...|:........|.::...|...|.||||..:.|:..||.
Yeast   531 ILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIY 595

  Fly   611 NT--LQLND-ETFQKHMQPIIESKLLNASSENLAGETRIELNLDYTNKRTKFKISSAL-----QK 667
            ..  :.::| ::....|..|...|:|..||.  :|..:..:|..:::...|.|:....     ||
Yeast   596 ELTHIPIDDVKSLVMSMSTIPRCKILKKSSS--SGNMKFSVNYFFSSPNRKVKVPVIACPLPSQK 658

  Fly   668 ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVL--SLSKVSFTPNIAMIKKCV 730
            ........::::.|.:..:.|.|.||||||....|.|..|::...  :.|::|.||:|  :|:.:
Yeast   659 SDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSI--LKRSI 721

  Fly   731 ESLIDKQYIERTANSGDEYSYMA 753
            :.||:|:||:|.|:....|.|::
Yeast   722 QLLIEKEYIQRNADDPSYYHYLS 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul2NP_610117.1 Cullin 39..639 CDD:279260 142/651 (22%)
CULLIN 436..575 CDD:214545 42/140 (30%)
Cullin_Nedd8 680..745 CDD:214883 25/66 (38%)
CUL3NP_011517.1 COG5647 1..744 CDD:227934 178/801 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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