Protein Alignment Cul2 and CUL3

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_011517.1
• Gene: CUL3 / 852886
• SGDID: S000003235
• Length: 744
• Species: Saccharomyces cerevisiae
• Alignment Length: 803
• Identity: 178/803 - (22%)
• Similarity: 358/803 - (44%)
• Gaps: 139/803 - (17%)

  Fly    10 FVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEMLA 74
            |.:.|..::...:.:.:....:.| :...:..:||:.:.:..|:   ||...|.:|   :|::..
Yeast    22 FEESWETVKYAIDHIYSDDMADLS-FEQVYKTIYTIVLNKKGPI---LYNRLKDYL---IQKLAL 79

  Fly    75 KKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSS 139
            .:..|..:.:|..   :.|......|.......|....|.:|:::.:.|..:.
Yeast    80 LRETIVKDNTHDY---EFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRC------------ 129

  Fly   140 DAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASN-GTLDHHRV---QIINGVIHSF 200
                 ||:.::.||::|:.:::..||.|:..::..|  :|..| |::|....   :::.|::.:.
Yeast   130 -----MEVYDMCLDLFRIEILQKCSSSLISALISDI--ERIRNLGSVDSEHTSLWKVLIGMMETL 187

  Fly   201 VEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKL--LHRCSVSEYMQEVIRILEYESRRAQ 263
            .:.:|       ..:...||..::.|:..||    ||.  :...:..|.::::.::.::||....
Yeast   188 HDNRD-------SFFLTDFEPVLISATEEYY----NKAIDIELLTPIESLEKIRKLRQFESMLDS 241

  Fly   264 KFLHVSSLPKLRKECEEKFINDRL----------------GFIYSECREMVSEERRQDLRNMYVV 312
            .||:|.|..||:...|...|..:|                |.:..|..::.|||:       |.|
Yeast   242 SFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEEK-------YRV 299

  Fly   313 LKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVH---HKYQE--------- 365
              .:.:::||.:....::...:||    :..||:|. |.:...:::::   |.:.|
Yeast   300 --TVIESIKSYINKNAINIPFNEG----NRKKGQNA-ITWSSEIVELYRSQHSFLESIDFGSVRL 357

  Fly   366 ----------LIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTCE 420
                      ::.|||   |::.|                ::....:||::.|.|..:|::|..:
Yeast   358 NNLTGDVSNAILGDVF---SMYFS----------------KEGALPSEYLSTYVDHCMKRTKEKD 403

  Fly   421 AE---IDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFT 482
            ||   |.|.|.::..:...:.:||:::|.|.:.|::||:.::| .::.|:.|:..:|:..|..||
Yeast   404 AEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRS-LVEIEKWMVQMIKKVLGTFFT 467

  Fly   483 NKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIP--FAVPQEFEK 545
            :||..|..|||:|.::...|. |...::::. ::.|.:||...:||..||..|.  .::|....:
Yeast   468 SKLEIMLRDISLSSEMYQAFQ-HSTINSIEY-LSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQ 530

  Fly   546 SIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQ 610
            .:..||.||...:..|.|.|.||:...|:........|.::...|...|.||||..:.|:..||.
Yeast   531 ILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIY 595

  Fly   611 NT--LQLND-ETFQKHMQPIIESKLLNASSENLAGETRIELNLDYTNKRTKFKISSAL-----QK 667
            ..  :.::| ::....|..|...|:|..||.  :|..:..:|..:::...|.|:....     ||
Yeast   596 ELTHIPIDDVKSLVMSMSTIPRCKILKKSSS--SGNMKFSVNYFFSSPNRKVKVPVIACPLPSQK 658

  Fly   668 ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVL--SLSKVSFTPNIAMIKKCV 730
            ........::::.|.:..:.|.|.||||||....|.|..|::...  :.|::|.||:|  :|:.:
Yeast   659 SDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSI--LKRSI 721

  Fly   731 ESLIDKQYIERTANSGDEYSYMA 753
            :.||:|:||:|.|:....|.|::
Yeast   722 QLLIEKEYIQRNADDPSYYHYLS 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	146/689 (21%)
		Cullin_Nedd8	683..745	CDD:463146	24/63 (38%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	178/801 (22%)