DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul2 and CDC53

DIOPT Version :9

Sequence 1:NP_610117.1 Gene:Cul2 / 35420 FlyBaseID:FBgn0032956 Length:753 Species:Drosophila melanogaster
Sequence 2:NP_010150.1 Gene:CDC53 / 851424 SGDID:S000002290 Length:815 Species:Saccharomyces cerevisiae


Alignment Length:815 Identity:211/815 - (25%)
Similarity:368/815 - (45%) Gaps:121/815 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 TLTKVERSVWNTSFSDVYT----LCVAQPEP----------------MADRLYGETKHFLEQHVQ 70
            |..:|.:.:..|.:.:|||    .||.:...                :...:|.:.|::|:.::.
Yeast    35 TSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNYIL 99

  Fly    71 EMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYG 135
            ..           ..|| ....||.|...|..::.|..:|:..:.|:|:..::|::         
Yeast   100 NF-----------KQSN-SETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKER--------- 143

  Fly   136 NLSSDAAEQM-EIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIHS 199
               ||....: ::..|.|..|:..|.:.....|:..:|:.:...|........:....|..::..
Yeast   144 ---SDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGREGQIIQRSNISTAIKSLVAL 205

  Fly   200 FVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQK 264
            .::.||.||. :|.:|.::||.|.|:.:..|||...|..|.:.||:||:.|...|::.|.:....
Yeast   206 GIDPQDLKKL-NLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTI 269

  Fly   265 FLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKP----IPDNLKSELI 325
            :....:...|.....:..|.|.:..:.:|...::.....:.:.::|.:::.    ||     .:.
Yeast   270 YWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLDARDIEKITSLYALIRRDFTLIP-----RMA 329

  Fly   326 TTFLDHIKSEGLQTVSAL---------KGENIH---IA-----------FVENMLKVHHKYQELI 367
            :.|.:::|..|...:|:|         |.||.:   :|           :::.:|:||..:.::.
Yeast   330 SVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIF 394

  Fly   368 ADVFENDSLFLSALDKACASVIN-------RRPTERQPCRSAEYVAKYCDTLLKKSKTCEAEIDQ 425
            .:.|.:|.....|||.||.:.||       ....:....:::|.:|||.|.||||:...|...|.
Yeast   395 NESFPDDIPLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDM 459

  Fly   426 KLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFT 490
            ...:.||||||:.|||.::..|.||.||||||..|.|.:.||.:|.||:.|...|:|.|:.:||.
Yeast   460 SDEDIITIFKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQ 524

  Fly   491 DISVSVDLNNKFNTHLK---DSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFED 552
            ||.:|..|.:.|...||   |.:.....:|...||....||. |.|.:.|.:|:|...|.:..::
Yeast   525 DIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPF-SYQEVEFKLPKELVPSHEKLKE 588

  Fly   553 YYHKLFSGRKLTWLHHMCHGELKL-----SHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNT 612
            .|.:..:||.|.||..:|.||||.     ..:..::.||:  :||||:||:...|.|:...||..
Yeast   589 SYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTL--FQMAILLLYNDADVLTLENIQEG 651

  Fly   613 LQLNDETFQKHMQPIIESKLLNASSENLAG----ETRIELNLDYTNKRTKFKISSALQKETPQ-- 671
            ..|..:.....|.|.|:.||:......|..    ||:.:|:..|...:|....:|.::.:..|  
Yeast   652 TSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKNDILQSL 716

  Fly   672 ------------------EVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVS 718
                              |.|.....::.:|::||:|.|||||||::.|.|..|:.|.::.|...
Yeast   717 SGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLVNECIAQSHQR 781

  Fly   719 FTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            |...::|:|:.::|||.|.|::| .:.|:.|:|:|
Yeast   782 FNAKVSMVKRAIDSLIQKGYLQR-GDDGESYAYLA 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul2NP_610117.1 Cullin 39..639 CDD:279260 169/662 (26%)
CULLIN 436..575 CDD:214545 54/141 (38%)
Cullin_Nedd8 680..745 CDD:214883 25/64 (39%)
CDC53NP_010150.1 COG5647 7..815 CDD:227934 210/813 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 60 1.000 Domainoid score I2560
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46807
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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