DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL2

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_011518045.1	Gene:	CUL2 / 8453	HGNCID:	2552	Length:	808	Species:	Homo sapiens

Alignment Length:	761	Identity:	385/761 - (50%)
Similarity:	537/761 - (70%)	Gaps:	24/761 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65
            |||||::|:|.:.|.:|....::|:.|..|||:.||..|||:|.||||.|||:.:|||.|||.||
Human    64 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFL 128

  Fly    66 EQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDT 130
            |.||:. |.|:||...|        .:|..|:..|.|||:|..|:..||.|||.|.|||.|:|:.
Human   129 ENHVRH-LHKRVLESEE--------QVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEA 184

  Fly   131 ESFYGNLSSDAAEQ-MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIIN 194
            :..||....|..|. ||||||.||:||..|:|.|.:.|:|.:|..|..||   |..|.:: ::|:
Human   185 DLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDR---GGEDPNQ-KVIH 245

  Fly   195 GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYES 259
            |||:|||.|:.|||...||.|||:||.|.|..:|.||..||:.||...:.|:||::|:..|:.|.
Human   246 GVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEE 310

  Fly   260 RRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSEL 324
            .|.:|:||.||..|:..||:::.:.|.|.|:::||..::.:|::.|:.||||:|:.:...| ..:
Human   311 IRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGL-PHM 374

  Fly   325 ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVI 389
            |....:||..|||:..|.|..||:...|||::|:||.|:.:||..|...|..|:||||||..||:
Human   375 IQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVV 439

  Fly   390 N-RRPTERQPCRSAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLL 451
            | |.|  :..|::.|.:|||||.|||||.  ..|.|::.:||:.||:||||:||||:||||:|:|
Human   440 NYREP--KSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARML 502

  Fly   452 AKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK--DSNVDLG 514
            ||||||..|.|||:||.|||:||||||||||:|||||:||:|||.|||||||..:|  |:.:|||
Human   503 AKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLG 567

  Fly   515 INLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL 579
            |:..|.|||||||||.......||:|||.|||::|||.:|.:.||||||||||::|.||:|:::|
Human   568 ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYL 632

  Fly   580 KKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASS--ENLAG 642
            .|.|:..:.|||||::|.|...:::|.:|:|::.|:|::...|.::.:::.|::|..|  |::..
Human   633 GKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDA 697

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            |:...||:::::|||||||::::||:||||:|.|.::||||||::|||||||||||||||:||||
Human   698 ESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNAL 762

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||||:|.|:..|.|:|:|||||:|.|||||||||:..|.|||||:|
Human   763 IQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	294/607 (48%)
		CULLIN	436..575	CDD:214545	95/140 (68%)
		Cullin_Nedd8	680..745	CDD:214883	49/64 (77%)
CUL2	XP_011518045.1	Cullin	93..706	CDD:279260	303/628 (48%)
		CULLIN	487..631	CDD:214545	96/143 (67%)
		Cullin_Nedd8	735..802	CDD:214883	50/66 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147530
Domainoid	1	1.000	579	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2662
Inparanoid	1	1.050	738	1.000	Inparanoid score	I597
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0007132
OrthoInspector	1	1.000	-	-		oto91175
orthoMCL	1	0.900	-	-		OOG6_106096
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5314
SonicParanoid	1	1.000	-	-		X5228
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800