DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL3

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001244127.1	Gene:	CUL3 / 8452	HGNCID:	2553	Length:	774	Species:	Homo sapiens

Alignment Length:	806	Identity:	208/806 - (25%)
Similarity:	383/806 - (47%)	Gaps:	113/806 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTS-------FSDVYTLCVAQPEPMADRLY 58
            |::..|.|.  .:|..|:      ..:.:::|.  |.|       :.:.||:.:   ....::||
Human    29 MTMDEKYVN--SIWDLLK------NAIQEIQRK--NNSGLSFEELYRNAYTMVL---HKHGEKLY 80

  Fly    59 GETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIK 123
            ...:..:.:|:...:.:.||       ::...:.||.....|.::...:..:..:.:|:::.:::
Human    81 TGLREVVTEHLINKVREDVL-------NSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ 138

  Fly   124 KQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEY--LSSELVRHILEGIAADRASNGTLD 186
            :..:   |:.|              .|||.|:|..::.|  :...|.:.:|:.||.:|
Human   139 QNNV---ENVY--------------NLGLIIFRDQVVRYGCIRDHLRQTLLDMIARER------- 179

  Fly   187 HHRVQIIN-GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQE 250
              :.:::: |.|.:..::..........:|:|.||.|.||.|..::..|:.|.|...|.|.|:::
Human   180 --KGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 242

  Fly   251 VIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIY----SECREMVSEERRQDLRNMYV 311
            |...:..|..|....|..|:...:.|..|.:.|:..:..|.    |....|:...:.:||..||.
Human   243 VEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYK 307

  Fly   312 VLKPIPDNLKS--ELITTFLDHIKSEGLQTVSALKGENIH-IAFVENMLKVHHKYQELIADVFEN 373
            :...:|:.||:  |.::::|   :.:|...||. :||..: :.:::.:|.:..::...:.:.|.|
Human   308 LFSRVPNGLKTMCECMSSYL---REQGKALVSE-EGEGKNPVDYIQGLLDLKSRFDRFLLESFNN 368

  Fly   374 DSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKK--SKTCEAEIDQKLTNNITIFKY 436
            |.||...:.......:|..      .||.||::.:.|..|||  ....|.|::..|...:.:|::
Human   369 DRLFKQTIAGDFEYFLNLN------SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRF 427

  Fly   437 IEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNK 501
            :::|||::::|.:.||:||:..:|.|.|:|:.||::||..||.:||:||..||.|:|:|....::
Human   428 MQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDE 492

  Fly   502 FNTHLKDSNVDL-GINLAIKVLQAGAWPLGSTQV---IPFAVPQEFEKSIKMFEDYYHKLFSGRK 562
            |..||:.:.|.| |::|.::||..|.||..|...   ||.|....||    :|..:|....|||:
Human   493 FRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFE----IFRRFYLAKHSGRQ 553

  Fly   563 LTWLHHMCHGELKLSH---LKK-------------------SYIVTMQTYQMAIILLFETCDSLS 605
            ||..|||...:|..:.   :||                   .:|:.:.|:||.|::||...:..:
Human   554 LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYT 618

  Fly   606 CREIQNTLQLNDETFQKHMQPIIESK------LLNASSENLAGETRIELNLDYTNK--RTKFKIS 662
            ..|||....:.:....:.:|.:...|      .....|:.:.......:|..:|:|  |.|.:..
Human   619 FEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTV 683

  Fly   663 SALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIK 727
            :|.|.|:..|.:.|...||:|||..::||||||||:||.::||.|:.||....|..|.|:..:||
Human   684 AAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIK 748

  Fly   728 KCVESLIDKQYIERTANSGDEYSYMA 753
            |.:|.||:::|:.||......|:|:|
Human   749 KRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	155/643 (24%)
		CULLIN	436..575	CDD:214545	55/142 (39%)
		Cullin_Nedd8	680..745	CDD:214883	32/64 (50%)
CUL3	NP_001244127.1	Cullin	41..670	CDD:279260	160/686 (23%)
		CULLIN	427..569	CDD:214545	56/145 (39%)
		Cullin_Nedd8	706..766	CDD:287520	28/59 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830