DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL4A

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001008895.1	Gene:	CUL4A / 8451	HGNCID:	2554	Length:	759	Species:	Homo sapiens

Alignment Length:	761	Identity:	193/761 - (25%)
Similarity:	365/761 - (47%)	Gaps:	81/761 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEML--- 73
            |.|.:|.....:|.:.|.:..:: ...:..|..||..:..||   ||.:.:...|.|||..:
Human    61 DTWRKLHEAVRAVQSSTSIRYNL-EELYQAVENLCSHKVSPM---LYKQLRQACEDHVQAQILPF 121

  Fly    74 ----AKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFY 134
                ...||             .|::....|.::.:.:..:..::::|::.::.:.....:
Human   122 REDSLDSVL-------------FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPS---- 169

  Fly   135 GNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVI 197
                        |.::||:::|.::|  :.:.|:.:..||..|..:| |...:|...::.:.|::
Human   170 ------------IWDMGLELFRTHIISDKMVQSKTIDGILLLIERER-SGEAVDRSLLRSLLGML 221

  Fly   198 HSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRA 262
                        ..|::|::.||...||.:...|..|..:|:....|.||:..|.:.||.|..|.
Human   222 ------------SDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV 274

  Fly   263 QKFLHVSSLPKLRKECEEKFINDRLGFIYSE-CREMVSEERRQDLRNMYVVLKPIPDNLKSELIT 326
            ..:|..|:...|....|::.:.:.|..|..: ...::.|.|..||..||.:...:... :..|:.
Human   275 ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGG-QQALLQ 338

  Fly   327 TFLDHIKSEGLQ-TVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVIN 390
            .:.::||:.|.. .::..|.:::    |:::|....|...:|...|:.:..|::.:.::..:.||
Human   339 HWSEYIKTFGTAIVINPEKDKDM----VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFIN 399

  Fly   391 RRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAK 453
            :||.     :.||.:||:.|:.|:  ..:..:.|:::.|...:.:|::|..|||::.||.:.|||
Human   400 KRPN-----KPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAK 459

  Fly   454 RLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLA 518
            ||:..:|.|:|||:.|:::||..||..||:||..||.|:.:|.|:...|..|:::.:....|:|.
Human   460 RLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLT 524

  Fly   519 IKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELK--LSHLKK 581
            :.:|..|.||..:...:  .:..|..|..::|:.:|....|||||.|...:.|..||  ....||
Human   525 VNILTMGYWPTYTPMEV--HLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKK 587

  Fly   582 SYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESK----LLNASSENLAG 642
            .:.|::  :|..::|:|...|..|..||:....:.|...::.:|.:...|    :.:...:.:..
Human   588 EFQVSL--FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVED 650

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            ..:...|.::.:|..:.||:....|||.:|...|...|.:||:..:.||||||||.||.|.||.|
Human   651 GDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            :.|:.:..|....|  ..:||.:|||||:.|:||..::.::|.|:|
Human   716 VSELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	146/618 (24%)
		CULLIN	436..575	CDD:214545	49/138 (36%)
		Cullin_Nedd8	680..745	CDD:214883	30/64 (47%)
CUL4A	NP_001008895.1	Cullin	65..657	CDD:307166	149/651 (23%)
CUL4A	NP_001008895.1	Cullin_Nedd8	688..753	CDD:214883	30/66 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830