DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL3B

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001319357.1	Gene:	CUL3B / 843303	AraportID:	AT1G69670	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	724	Identity:	204/724 - (28%)
Similarity:	361/724 - (49%)	Gaps:	82/724 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGP--DLLQRYYITWMEYSQGIKYLHQLYIYL 117
            |:||......:..|::| :.|.:      ..:.||.  :||.|   .|.::::.::.:..:.:|:
plant    66 DKLYTGLVTTMTFHLKE-ICKSI------EEAQGGAFLELLNR---KWNDHNKALQMIRDILMYM 120

  Fly   118 NQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRA 180
            ::.::...|.|                 .:.||||.:||..::  ..:.:.|:..:|:.:..:|.
plant   121 DRTYVSTTKKT-----------------HVHELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERT 168

  Fly   181 SNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVS 245
            .. .:|  || ::..||..|:::.:       .:||:.||.|.||||..:|..|:.:.:..|...
plant   169 GE-VID--RV-LMRNVIKMFMDLGE-------SVYQDDFEKPFLEASAEFYKVESMEFIESCDCG 222

  Fly   246 EYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRL---------GFIYSECREMVSEE 301
            ||:::..:.|..|..|...:|...|..|:....|.:.|.:.:         |.:     .|:..:
plant   223 EYLKKAEKPLVEEVERVVNYLDAKSEAKITSVVEREMIANHVQRLVHMENSGLV-----NMLLND 282

  Fly   302 RRQDLRNMYVVLKPIPDNLKS--ELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQ 364
            :.:|:..||.:.:.:.:.|.:  :::|.   |::..|.|.|:..:.....:.||:.:|....||.
plant   283 KYEDMGRMYSLFRRVANGLVTVRDVMTL---HLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYD 344

  Fly   365 ELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKK--SKTCEAEIDQKL 427
            .:|...|.||..|.:||:.:....:|..      .||.|:::.:.|..|:|  ....|.::|..|
plant   345 RIINMAFNNDKTFQNALNSSFEYFVNLN------TRSPEFISLFVDDKLRKGLKGVGEEDVDLIL 403

  Fly   428 TNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDI 492
            ...:.:|:|:::|||::|:|.:.|||||:..::.|.|||..:|.:||..|||:||:||..||||:
plant   404 DKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERNLIVKLKTECGYQFTSKLEGMFTDM 468

  Fly   493 SVSVD-LNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHK 556
            ..|.| |...:|:|.:.|.   |..|.::||..|:||...|  |...:|.|.....:.|..||..
plant   469 KTSHDTLLGFYNSHPELSE---GPTLVVQVLTTGSWPTQPT--IQCNLPAEVSVLCEKFRSYYLG 528

  Fly   557 LFSGRKLTWLHHMCHGELKLSHLK-KSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETF 620
            ..:||:|:|..:|...::|....| :.:.:.:.|:||.:::||...|.||.:||:...::.....
plant   529 THTGRRLSWQTNMGTADIKAVFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDL 593

  Fly   621 QKHMQPIIESKLLNA-----SSENLAGETRIELNLDYTNKRTKFKISSAL-QKETPQEVEHTINS 679
            ::.:|.:...|..|.     .|:.:|.|....:|..:.:|..|.||.:.: ||||..|.:.|...
plant   594 KRCLQSMACVKGKNVLRKEPMSKEIAEEDWFVVNDRFASKFYKVKIGTVVAQKETEPEKQETRQR 658

  Fly   680 VDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTAN 744
            |:||||..::||||||||:|:||.||.:|.||....:..|..|...|||.:||||::.::||...
plant   659 VEEDRKPQIEAAIVRIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEIKKRIESLIERDFLERDNT 723

  Fly   745 SGDEYSYMA 753
            ....|.|:|
plant   724 DRKLYRYLA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	156/607 (26%)
		CULLIN	436..575	CDD:214545	54/139 (39%)
		Cullin_Nedd8	680..745	CDD:214883	32/64 (50%)
CUL3B	NP_001319357.1	Cullin	29..630	CDD:366357	159/620 (26%)
CUL3B	NP_001319357.1	Cullin_Nedd8	659..726	CDD:214883	32/66 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830