DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL2

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001318910.1	Gene:	CUL2 / 839415	AraportID:	AT1G02980	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	753	Identity:	196/753 - (26%)
Similarity:	344/753 - (45%)	Gaps:	92/753 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FSDVYTLCVAQP-----EPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYI 98
            ::.|:.||..:|     :.:.||..|....:.:|.|...:.:|        |   |..:|:....
plant    44 YTTVHNLCTQKPPNDYSQQIYDRYGGVYVDYNKQTVLPAIREK--------H---GEYMLRELVK 97

  Fly    99 TWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYL 163
            .|......:::|...:.||::             ||....|...    :..:|...:|..:.:.|
plant    98 RWANQKILVRWLSHFFEYLDR-------------FYTRRGSHPT----LSAVGFISFRDLVYQEL 145

  Fly   164 SSELVRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASG 228
            .|:....:|..|..:|...        ||...::.:.::|......|.|..|:|.||..:||.|.
plant   146 QSKAKDAVLALIHKEREGE--------QIDRALLKNVIDVYCGNGMGELVKYEEDFESFLLEDSA 202

  Fly   229 AYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFI---------N 284
            :||:..|::.....|..:||.:....|..|..|...:||.::.|||..:.:.:.:         |
plant   203 SYYSRNASRWNQENSCPDYMIKAEESLRLEKERVTNYLHSTTEPKLVAKVQNELLVVVAKQLIEN 267

  Fly   285 DRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEG------------- 336
            :     :|.||.::.:::..||..||.:..|||..| ..:...|..||..||
plant   268 E-----HSGCRALLRDDKMDDLARMYRLYHPIPQGL-DPVADLFKQHITVEGSALIKQATEAATD 326

  Fly   337 -LQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCR 400
             ..:.|.||.::  ...:..::.:|.|:...:.:.|:..|||..||.:|.....|:...   ...
plant   327 KAASTSGLKVQD--QVLIRQLIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCNKTVA---GVS 386

  Fly   401 SAEYVAKYCDTLLKK----SKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQ 461
            |||.:|.|||.:||.    .|....:::..|...:.:..||.|||::.:|:.:..|:||:.:::.
plant   387 SAEILATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQARRLLFDRNG 451

  Fly   462 SMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK-DSNVDLGINLAIKVLQAG 525
            :...|..::.:.|:..|.:||:|:..|.||::::.:....|...|. :....||::..:.||..|
plant   452 NDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTG 516

  Fly   526 AWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTY 590
            .||  |.:.....:|.|....::.|:.||....:.|:|:|::.:...:|.....||:..:.:.||
plant   517 FWP--SYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRRLSWIYSLGTCQLAGKFDKKTIEIVVTTY 579

  Fly   591 QMAIILLFETCDSLSCREIQNTLQLNDETFQK--HMQPIIESKLL--NASSENLAGETRIELNLD 651
            |.|::|||...:.||..||...|.|..|...:  |....::.|:|  ...|.|::.....|.|..
plant   580 QAAVLLLFNNTERLSYTEILEQLNLGHEDLARLLHSLSCLKYKILIKEPMSRNISNTDTFEFNSK 644

  Fly   652 YTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQE-VLSLS 715
            :|:|..:.::......|..:.||    .||:||:..:.||:|||||:||||.|..|:.| |..||
plant   645 FTDKMRRIRVPLPPMDERKKIVE----DVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLS 705

  Fly   716 KVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            |: |.|:|.||||.:|.||.:.|:||..::.:.:.|:|
plant   706 KM-FKPDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	151/636 (24%)
		CULLIN	436..575	CDD:214545	36/139 (26%)
		Cullin_Nedd8	680..745	CDD:214883	35/65 (54%)
CUL2	NP_001318910.1	Cullin	12..645	CDD:366357	154/649 (24%)
CUL2	NP_001318910.1	Cullin_Nedd8	669..736	CDD:214883	35/67 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830