Protein Alignment Cul2 and CUL3

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_174005.1
• Gene: CUL3 / 839226
• AraportID: AT1G26830
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 737
• Identity: 205/737 - (27%)
• Similarity: 371/737 - (50%)
• Gaps: 73/737 - (9%)

  Fly    38 SFSDVYTLCVAQPEPMADRLYGETKH--FLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITW 100
            ||.::|    .....|....:||..:  |:......:..|..|||.    :.|| ..|:.....|
plant    48 SFEELY----RNAYNMVLHKFGEKLYTGFIATMTSHLKEKSKLIEA----AQGG-SFLEELNKKW 103

  Fly   101 MEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEY--L 163
            .|:::.::.:..:.:|:::.:|:..|.|                 .:..:||::||..::.:  :
plant   104 NEHNKALEMIRDILMYMDRTYIESTKKT-----------------HVHPMGLNLWRDNVVHFTKI 151

  Fly   164 SSELVRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASG 228
            .:.|:..:|:.:..:|... .:|.   .::..||..|:::.:       .:|||.||.|.|:||.
plant   152 HTRLLNTLLDLVQKERIGE-VIDR---GLMRNVIKMFMDLGE-------SVYQEDFEKPFLDASS 205

  Fly   229 AYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFI-NDRLGFIYS 292
            .:|..|:.:.:..|...:|:::..:.|..|..|...:|...|..|:....|::.| |.....::.
plant   206 EFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHM 270

  Fly   293 ECREMVS---EERRQDLRNMYVVLKPIPDNLKS--ELITTFLDHIKSEGLQTVSALKGENIHIAF 352
            |...:|:   .::.:||..||.:.:.:.:.|.:  :::|:   |::..|.|.|:..:.....:.|
plant   271 ENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVTVRDVMTS---HLREMGKQLVTDPEKSKDPVEF 332

  Fly   353 VENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSK 417
            |:.:|....||.::|...|.||..|.:||:.:....||..      .||.|:::.:.|..|:|..
plant   333 VQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLN------ARSPEFISLFVDDKLRKGL 391

  Fly   418 TCEAEIDQK--LTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYE 480
            ....::|.:  |...:.:|:|:::|||::|:|.:.|||||:..::.|.|||..:|.:||..|||:
plant   392 KGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQ 456

  Fly   481 FTNKLHRMFTDISVSVD-LNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQ-VIPFAVPQEF 543
            ||:||..||||:..|.| :...:.:|.:.|.   |..|.::||..|:||   || .:|..:|.|.
plant   457 FTSKLEGMFTDMKTSEDTMRGFYGSHPELSE---GPTLIVQVLTTGSWP---TQPAVPCNLPAEV 515

  Fly   544 EKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLK-KSYIVTMQTYQMAIILLFETCDSLSCR 607
            ....:.|..||....:||:|:|..:|...::|....| :.:.:.:.|:||.:::||...|.||.:
plant   516 SVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYK 580

  Fly   608 EIQNTLQLNDETFQKHMQPIIESKLLNA-----SSENLAGETRIELNLDYTNKRTKFKISSAL-Q 666
            ||:...::.....::.:|.:...|..|.     .|:::..|....:|..:|:|..|.||.:.: |
plant   581 EIEQATEIPAADLKRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQ 645

  Fly   667 KETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVE 731
            |||..|.:.|...|:||||..::||||||||:||:|.||.:|.||....:..|..|...|||.:|
plant   646 KETEPEKQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIE 710

  Fly   732 SLIDKQYIERTANSGDEYSYMA 753
            |||::.::||.:.....|.|:|
plant   711 SLIERDFLERDSTDRKLYRYLA 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	159/633 (25%)
		Cullin_Nedd8	683..745	CDD:463146	30/61 (49%)
CUL3	NP_174005.1	Cullin	29..630	CDD:459983	159/633 (25%)
		Cullin_Nedd8	662..724	CDD:463146	30/61 (49%)