DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and CUL1

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001031575.1	Gene:	CUL1 / 825648	AraportID:	AT4G02570	Length:	738	Species:	Arabidopsis thaliana

Alignment Length:	751	Identity:	203/751 - (27%)
Similarity:	363/751 - (48%)	Gaps:	91/751 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FSDVYTLCVAQ-PEPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWME 102
            ::.:|.:|..: |...:.:||.:.:...|:::...:...:       .......:|:..:..|..
plant    43 YTTIYNMCTQKPPHDYSQQLYDKYREAFEEYINSTVLPAL-------REKHDEFMLRELFKRWSN 100

  Fly   103 YSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSEL 167
            :...:::|.:.:.||::..|.::.:.                 .:.|:||..:|..:...|.|::
plant   101 HKVMVRWLSRFFYYLDRYFIARRSLP-----------------PLNEVGLTCFRDLVYNELHSKV 148

  Fly   168 VRHIL-------EGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLE 225
            .:.::       ||...|||           ::..|:..:||:    ..|.::.|:|.||..||:
plant   149 KQAVIALVDKEREGEQIDRA-----------LLKNVLDIYVEI----GMGQMERYEEDFESFMLQ 198

  Fly   226 ASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEK----FINDR 286
            .:.:||:.:|:..:...|..:||.:....|:.|..|...:||.||.|||.::.:.:    |.:..
plant   199 DTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQHELLVVFASQL 263

  Fly   287 LGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTV----------- 340
            |...:|.||.::.:::..||..||.:...|...|: .:...|..|:.:||...|
plant   264 LEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLE-PVANIFKQHVTAEGNALVQQAEDTATNQV 327

  Fly   341 --SALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAE 403
              :|...|.:   .:..::::|.||...:.:.|:|.:||..||.:|.....|:......   |||
plant   328 ANTASVQEQV---LIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSS---SAE 386

  Fly   404 YVAKYCDTLLKK---SKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDA 465
            .:|.:||.:|||   .|..:..|:..|...:.:..||.|||::.:||.:.||:||:.::|.:.|.
plant   387 LLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDDH 451

  Fly   466 EEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSN--VDLGINLAIKVLQAGAWP 528
            |..::.:|||.||.:||:|:..|.||::::.:..|.|..:| .||  .:.||:|.:.||..|.||
plant   452 ERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYL-GSNPAANPGIDLTVTVLTTGFWP 515

  Fly   529 LGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHM--CHGELKLSHLKKSYIVTMQTYQ 591
              |.:.....:|.|..|.:::|:.:|......|||||::.:  ||...|..  :|:..:.:.|||
plant   516 --SYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFD--QKAIELIVSTYQ 576

  Fly   592 MAIILLFETCDSLSCREIQNTLQLNDETFQK--HMQPIIESKLL--NASSENLAGETRIELNLDY 652
            .|::|||.|.|.||..||...|.|:.|...:  |.....:.|:|  ..:::.::.....|.|..:
plant   577 AAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKF 641

  Fly   653 TNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKV 717
            |::..:.||......|..:.||    .||:||:..:.||||||||:||||.|..|:.|.:.....
plant   642 TDRMRRIKIPLPPVDERKKVVE----DVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSR 702

  Fly   718 SFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .|.|:|..|||.:|.||.:.|:||...:.:.:.|:|
plant   703 MFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	162/635 (26%)
		CULLIN	436..575	CDD:214545	51/142 (36%)
		Cullin_Nedd8	680..745	CDD:214883	31/64 (48%)
CUL1	NP_001031575.1	Cullin	12..641	CDD:395716	164/648 (25%)
CUL1	NP_001031575.1	Cullin_Nedd8	668..729	CDD:402267	29/60 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830