Protein Alignment Cul2 and CUL1

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_567243.1
• Gene: CUL1 / 825648
• AraportID: AT4G02570
• Length: 738
• Species: Arabidopsis thaliana
• Alignment Length: 751
• Identity: 203/751 - (27%)
• Similarity: 363/751 - (48%)
• Gaps: 91/751 - (12%)

  Fly    39 FSDVYTLCVAQ-PEPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWME 102
            ::.:|.:|..: |...:.:||.:.:...|:::...:...:       .......:|:..:..|..
plant    43 YTTIYNMCTQKPPHDYSQQLYDKYREAFEEYINSTVLPAL-------REKHDEFMLRELFKRWSN 100

  Fly   103 YSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSEL 167
            :...:::|.:.:.||::..|.::.:.                 .:.|:||..:|..:...|.|::
plant   101 HKVMVRWLSRFFYYLDRYFIARRSLP-----------------PLNEVGLTCFRDLVYNELHSKV 148

  Fly   168 VRHIL-------EGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLE 225
            .:.::       ||...|||           ::..|:..:||:    ..|.::.|:|.||..||:
plant   149 KQAVIALVDKEREGEQIDRA-----------LLKNVLDIYVEI----GMGQMERYEEDFESFMLQ 198

  Fly   226 ASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEK----FINDR 286
            .:.:||:.:|:..:...|..:||.:....|:.|..|...:||.||.|||.::.:.:    |.:..
plant   199 DTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQHELLVVFASQL 263

  Fly   287 LGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTV----------- 340
            |...:|.||.::.:::..||..||.:...|...|: .:...|..|:.:||...|
plant   264 LEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLE-PVANIFKQHVTAEGNALVQQAEDTATNQV 327

  Fly   341 --SALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAE 403
              :|...|.:   .:..::::|.||...:.:.|:|.:||..||.:|.....|:......   |||
plant   328 ANTASVQEQV---LIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKTVAGSS---SAE 386

  Fly   404 YVAKYCDTLLKK---SKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDA 465
            .:|.:||.:|||   .|..:..|:..|...:.:..||.|||::.:||.:.||:||:.::|.:.|.
plant   387 LLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDDH 451

  Fly   466 EEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSN--VDLGINLAIKVLQAGAWP 528
            |..::.:|||.||.:||:|:..|.||::::.:..|.|..:| .||  .:.||:|.:.||..|.||
plant   452 ERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYL-GSNPAANPGIDLTVTVLTTGFWP 515

  Fly   529 LGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHM--CHGELKLSHLKKSYIVTMQTYQ 591
              |.:.....:|.|..|.:::|:.:|......|||||::.:  ||...|..  :|:..:.:.|||
plant   516 --SYKSFDINLPSEMIKCVEVFKGFYETKTKHRKLTWIYSLGTCHINGKFD--QKAIELIVSTYQ 576

  Fly   592 MAIILLFETCDSLSCREIQNTLQLNDETFQK--HMQPIIESKLL--NASSENLAGETRIELNLDY 652
            .|::|||.|.|.||..||...|.|:.|...:  |.....:.|:|  ..:::.::.....|.|..:
plant   577 AAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKF 641

  Fly   653 TNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKV 717
            |::..:.||......|..:.||    .||:||:..:.||||||||:||||.|..|:.|.:.....
plant   642 TDRMRRIKIPLPPVDERKKVVE----DVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSR 702

  Fly   718 SFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .|.|:|..|||.:|.||.:.|:||...:.:.:.|:|
plant   703 MFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	164/648 (25%)
		Cullin_Nedd8	683..745	CDD:463146	29/61 (48%)
CUL1	NP_567243.1	Cullin	12..641	CDD:459983	164/648 (25%)
		Cullin_Nedd8	668..730	CDD:463146	29/61 (48%)