DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul5

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_082083.3	Gene:	Cul5 / 75717	MGIID:	1922967	Length:	780	Species:	Mus musculus

Alignment Length:	807	Identity:	207/807 - (25%)
Similarity:	375/807 - (46%)	Gaps:	100/807 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEM 72
            ::|.|.|..:..|...::....|.:..|...||||:.:|: ..:..:.:::...|..:.:.:::.
Mouse    13 LQFEDKWDFMHPIVLKLLRQESVTKQQWFDLFSDVHAVCL-WDDKGSSKIHQALKEDILEFIKQA 76

  Fly    73 LAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNL 137
            .|:.:      ||.: ...||:.|.:.|.::......|.:.:..|....:.||
Mouse    77 QARVL------SHQD-DTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQ------------ 122

  Fly   138 SSDAAEQME---IGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIHS 199
            ||:....||   :.:|.||.|...:...:.:.|....::.:.|:|... ..|.   |::.||..|
Mouse   123 SSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGE-AFDS---QLVIGVRES 183

  Fly   200 FVEV----QDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESR 260
            :|.:    :|     .|::|::.||...|:::..:|..:|...|.:..|..||:.....|:.|.:
Mouse   184 YVNLCSNPED-----KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEK 243

  Fly   261 RAQKFLHV----SSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLK 321
            ||.::|..    :|:..|.:.|....:......|.:||:.|:.....:.|..|:.::..:|:.::
Mouse   244 RALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIE 308

  Fly   322 SELITTFLDHIKSEGLQTVSALKGENIHI---AFVENMLKVHHKYQELIADVFENDSLFLSALDK 383
             .::....:||.|.||..:.| ..|.|..   .:||.:|.:.:::.:|:.:.|::|..||:|.||
Mouse   309 -PMLKDLEEHIISAGLADMVA-AAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDK 371

  Fly   384 ACASVIN-------------------RRPTERQPCRSAEYVAKYCDTLLKKS----KTCEAEIDQ 425
            |..:|:|                   .:|..:.|    |.:|.|||.||:|:    |....||:.
Mouse   372 AYKAVVNDATIFKLELPLKQKGVGLKTQPESKCP----ELLANYCDMLLRKTPLSKKLTSEEIEA 432

  Fly   426 KLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQ-ACGYEFTNKLHRMF 489
            ||...:.:.||:::|||:.:::...|.:|||.:.|...:.||.|:..|:: ....::.|||.|||
Mouse   433 KLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMF 497

  Fly   490 TDISVSVDLNNKFNTHLKDSNVDL---GINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFE 551
            .||.||.|||..|....|::.:.|   .:|  ||:|.||||...|.:|. .::|.|.|..|...|
Mouse   498 QDIKVSEDLNQAFKEMHKNNKLALPADSVN--IKILNAGAWSRSSEKVF-VSLPTELEDLIPEVE 559

  Fly   552 DYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLF--ETCDSLSCREIQNTLQ 614
            ::|.|..|||||.|.|.|.:|.:...:....|.:.:.|:|:|::..:  ...:.:|...::...:
Mouse   560 EFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE 624

  Fly   615 LNDETFQKHM-----------QPIIESKLLNASSENLAGETRIELNLDYT-------NKRTKFKI 661
            |.|...::.:           |.::....:|:..:...| |...:|.|::       .||.|..:
Mouse   625 LPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEG-TLFSVNQDFSLIKNAKVQKRGKINL 688

  Fly   662 SSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMI 726
            ...||..|.:..|.....:.:.|.|..|.||::|||.||.:.:..|..|::.:.|..|.|...||
Mouse   689 IGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMI 753

  Fly   727 KKCVESLIDKQYIERTANSGDEYSYMA 753
            |:.:|.||:.:||.|.....:.:.|||
Mouse   754 KEQMEWLIEHRYIRRDEADINTFIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	163/653 (25%)
		CULLIN	436..575	CDD:214545	55/142 (39%)
		Cullin_Nedd8	680..745	CDD:214883	24/64 (38%)
Cul5	NP_082083.3	Cullin	19..672	CDD:334305	170/691 (25%)
Cul5	NP_082083.3	Cullin_Nedd8	713..772	CDD:337788	23/58 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820