Protein Alignment Cul2 and cul1

DIOPT Version :9

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_001039255.1
• Gene: cul1 / 734121
• XenbaseID: XB-GENE-945766
• Length: 776
• Species: Xenopus tropicalis
• Alignment Length: 790
• Identity: 277/790 - (35%)
• Similarity: 429/790 - (54%)
• Gaps: 82/790 - (10%)

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADR--------------------- 56
            :|..||...:.|.|...:.:|.:...::.||..|.:..:....|
 Frog    20 IWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFV 84

  Fly    57 ---LYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIKYLHQL 113
               ||...|.||:.::..:|             ..|.||     |:.|...|.:|....|.|:.:
 Frog    85 GLELYKRLKEFLKNYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSKVLNGI 136

  Fly   114 YIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAAD 178
            ..|||:..::::.....:..|           ||..|.|..||..:.:.|:.::...:|:.|..:
 Frog   137 CAYLNRHWVRRECDEGRKGIY-----------EIYSLALVTWRDCLFKPLNKQVTNAVLKLIEKE 190

  Fly   179 RASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTDEANKL 238
            |  ||...:.|  :|:||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.|:.:.
 Frog   191 R--NGETINTR--LISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEF 251

  Fly   239 LHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEER 302
            |.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.::..::
 Frog   252 LQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADK 315

  Fly   303 RQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSAL--KGENIHIAFVENMLKVHHKYQE 365
            .:||..||.::..|.|.| .||......||.::||..:...  ..:|....:|:.:|.||.||..
 Frog   316 NEDLGRMYNLVSRIQDGL-GELKKLLETHIHNQGLAAIEKCGEAAQNDPKMYVQTVLDVHKKYNA 379

  Fly   366 LIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC--EAEIDQ 425
            |:...|.||:.|::||||||...||.....:   ...:|.|.:|:|||:|||||...  |||::.
 Frog   380 LVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELED 444

  Fly   426 KLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFT 490
            .|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|:||.|||.
 Frog   445 TLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQ 509

  Fly   491 DISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYH 555
            ||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.:.|..:|.
 Frog   510 DIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPF--QQFCTFALPSELERSYQRFTAFYA 571

  Fly   556 KLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETF 620
            ...||||||||:.:..|||..:..|..|.:...|:||||:|.:.|.|:.:.:::.::.|:..:..
 Frog   572 SRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDIL 636

  Fly   621 QKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTIN 678
            .:.:|.:::||||....||       |..:..|:|.|.|.||:.:..|:..::.|..||.|.|..
 Frog   637 VQVLQILLKSKLLVLEDENANVDDVDLKPDILIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHK 701

  Fly   679 SVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTA 743
            :::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:|:|:||..
 Frog   702 NIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVD 766

  Fly   744 NSGDEYSYMA 753
            ...|.|||:|
 Frog   767 GEKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	215/641 (34%)
		CULLIN	436..575	CDD:214545	74/138 (54%)
		Cullin_Nedd8	680..745	CDD:214883	36/64 (56%)
cul1	NP_001039255.1	Cullin	21..662	CDD:366357	223/673 (33%)
		Cullin_Nedd8	703..770	CDD:214883	36/66 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930