DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul2 and Cul4b

DIOPT Version :9

Sequence 1:NP_610117.1 Gene:Cul2 / 35420 FlyBaseID:FBgn0032956 Length:753 Species:Drosophila melanogaster
Sequence 2:NP_001103612.1 Gene:Cul4b / 72584 MGIID:1919834 Length:970 Species:Mus musculus


Alignment Length:770 Identity:200/770 - (25%)
Similarity:377/770 - (48%) Gaps:81/770 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KPKIVE-FVD-VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLE 66
            |||:.| :.| .|.:|:...|::...|.::.:: ...:..|..||   ...::..||.:.:...|
Mouse   262 KPKLPENYTDETWQKLKEAVEAIQNSTSIKYNL-EELYQAVENLC---SHKISANLYKQLRQICE 322

  Fly    67 QHVQEMLAK-------KVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKK 124
            .|::..:.:       .||             .|::....|..:.:.:..:..::::|::.::.:
Mouse   323 DHIKAQIHQFREDSLDSVL-------------FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ 374

  Fly   125 QKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRASNGTLDH 187
            ..:..:                |.::||:::|.::|  :.:.::.:..||  :..:|..||.   
Mouse   375 NSMLPS----------------IWDMGLELFRAHIISDQKVQTKTIDGIL--LLIERERNGE--- 418

  Fly   188 HRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVI 252
               .|...::.|.:.:     ...|::||:.||...|:.:...|..|..||:....|.||:..|.
Mouse   419 ---AIDRSLLRSLLSM-----LSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVN 475

  Fly   253 RILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSE-CREMVSEERRQDLRNMYVVLKPI 316
            :.||.|:.|...:|..::...|....|::.:.:.|..|..: ...::.|.|.|||..:|.:...:
Mouse   476 KRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRV 540

  Fly   317 PDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSAL 381
            ...:: .|:..::::||:.|...|...:.:.   ..|:.:|....|...:|...|..:..|::|:
Mouse   541 RGGVQ-VLLQQWIEYIKAFGSTIVINPEKDK---TMVQELLDFKDKVDHIIDTCFLKNEKFINAM 601

  Fly   382 DKACASVINRRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIFKYIEDKDVYQ 444
            .:|..:.||:||.     :.||.:|||.|:.|:  ..:..:.|:::.|...:.||::|..|||::
Mouse   602 KEAFETFINKRPN-----KPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFE 661

  Fly   445 KFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDS 509
            .||.:.|||||:..:|.|:|||:.|:::||..||..||:||..||.|:.:|.|:..:|..::::.
Mouse   662 AFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQ 726

  Fly   510 NVDLGINLAIKVLQAGAWPLGSTQVIPFAV--PQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHG 572
            ||...|.|.:.:|..|.||    ..:|..|  |.|..|..::|:.:|....|||||.|...:.|.
Mouse   727 NVPGNIELTVNILTMGYWP----TYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHC 787

  Fly   573 ELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPII--ESKLL-- 633
            .||....:....:.:..:|..::|:|...:..|..||::...:.|...::.:|.:.  ::::|  
Mouse   788 VLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAK 852

  Fly   634 NASSENLAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKA 698
            |...:::....:...|.|:.:|..:.||:....|||.:|...|...|.:||:..:.||||||||.
Mouse   853 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKM 917

  Fly   699 RKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||.|.||.|:.||.:..|....|  |.:||.:|||||:.|:||...:.::|:|:|
Mouse   918 RKTLSHNLLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYNYIA 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul2NP_610117.1 Cullin 39..639 CDD:279260 146/617 (24%)
CULLIN 436..575 CDD:214545 53/140 (38%)
Cullin_Nedd8 680..745 CDD:214883 32/64 (50%)
Cul4bNP_001103612.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q13620 112..115
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..211
Cullin 275..870 CDD:279260 150/653 (23%)
CULLIN 653..793 CDD:214545 55/143 (38%)
Cullin_Nedd8 899..964 CDD:214883 32/66 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.830

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