DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul2

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001347758.1	Gene:	Cul2 / 71745	MGIID:	1918995	Length:	745	Species:	Mus musculus

Alignment Length:	761	Identity:	384/761 - (50%)
Similarity:	534/761 - (70%)	Gaps:	24/761 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65
            |||||::|:|.:.|.:|....::|:.|..|||:.||..|||:|.||||.|||:.:|||.|||.||
Mouse     1 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIFL 65

  Fly    66 EQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDT 130
            |.||:. |.|:||...|        .:|..|:..|.|||:|..|:..||.|||.|:|||.|:|:.
Mouse    66 ESHVRH-LYKRVLESEE--------QVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEA 121

  Fly   131 ESFYGNLSSDAAEQ-MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIIN 194
            :..||....|..|. ||||||.||:||..|:|.|.:.|:|.:|..|..||   |..|.:: ::|:
Mouse   122 DIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDR---GGEDPNQ-KVIH 182

  Fly   195 GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYES 259
            |||:|||.|:.|||...||.||.:|..|.|..:|.||..||:.||...:.|:||::|:..|:.|.
Mouse   183 GVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEE 247

  Fly   260 RRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSEL 324
            .|.:|:||.||..|:..||:::.:.|.|.|::|||..::.:||:.|:.||||:|:.:...| ..:
Mouse   248 IRCRKYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIQQERKNDMANMYVLLRAVSSGL-PHM 311

  Fly   325 ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVI 389
            |.....||..|||:..|.|..|::...|||::|:||.|:.:||..|...|..|:||||||..||:
Mouse   312 IEELQKHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVV 376

  Fly   390 N-RRPTERQPCRSAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLL 451
            | |.|  :..|::.|.:|||||.|||||.  ..|.|::.|||:.||:||||:||||:||||:|:|
Mouse   377 NYREP--KSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARML 439

  Fly   452 AKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK--DSNVDLG 514
            ||||||..|.|||:||.|||:||||||||||:|||||:||:|||.|||||||..::  |:.:|||
Mouse   440 AKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLG 504

  Fly   515 INLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL 579
            |:..|.|||||||||.......||:|||.|||::|||.:|.:.||||||||||::|.||:|:::|
Mouse   505 ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYL 569

  Fly   580 KKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASS--ENLAG 642
            .|.|:..:.|||||::|.|...:::|.:|:|::.|:|::...|.::.:::.|::|..|  |::..
Mouse   570 GKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDA 634

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            |:...||:.:::|||||||::::||:||||:|.|.::||||||::|||||||||||||||:||||
Mouse   635 ESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNAL 699

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||||:|.|:..|.|:|:|||||:|.|||||||||:..|.|||||:|
Mouse   700 IQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	293/607 (48%)
		CULLIN	436..575	CDD:214545	94/140 (67%)
		Cullin_Nedd8	680..745	CDD:214883	49/64 (77%)
Cul2	NP_001347758.1	Cullin	14..644	CDD:366357	303/637 (48%)
Cul2	NP_001347758.1	Cullin_Nedd8	677..735	CDD:371133	41/57 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837609
Domainoid	1	1.000	576	1.000	Domainoid score	I220
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2662
Inparanoid	1	1.050	736	1.000	Inparanoid score	I595
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0007132
OrthoInspector	1	1.000	-	-		oto94758
orthoMCL	1	0.900	-	-		OOG6_106096
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5314
SonicParanoid	1	1.000	-	-		X5228
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800