Protein Alignment Cul2 and cul3

DIOPT Version :9

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_001015975.2
• Gene: cul3 / 548729
• XenbaseID: XB-GENE-974982
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 806
• Identity: 208/806 - (25%)
• Similarity: 382/806 - (47%)
• Gaps: 113/806 - (14%)

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTS-------FSDVYTLCVAQPEPMADRLY 58
            |::..|.|.  .:|..|:      ..:.:::|.  |.|       :.:.||:.:   ....::||
 Frog    23 MTMDEKYVN--SIWDLLK------NAIQEIQRK--NNSGLSFEELYRNAYTMVL---HKHGEKLY 74

  Fly    59 GETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIK 123
            ...:..:.:|:...:.:.||       ::...:.||.....|.::...:..:..:.:|:::.:::
 Frog    75 TGLREVVTEHLINKVREDVL-------NSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ 132

  Fly   124 KQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEY--LSSELVRHILEGIAADRASNGTLD 186
            :..:   |:.|              .|||.|:|..::.|  :...|.:.:|:.||.:|
 Frog   133 QNNV---ENVY--------------NLGLIIFRDQVVRYGCIRDHLRQTLLDMIARER------- 173

  Fly   187 HHRVQIIN-GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQE 250
              :.:::: |.|.:..::..........:|:|.||.|.||.|..::..|:.|.|...|.|.|:::
 Frog   174 --KGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236

  Fly   251 VIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIY----SECREMVSEERRQDLRNMYV 311
            |...:..|..|....|..|:...:.|..|.:.|:..:..|.    |....|:...:.:||..||.
 Frog   237 VEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYK 301

  Fly   312 VLKPIPDNLKS--ELITTFLDHIKSEGLQTVSALKGENIH-IAFVENMLKVHHKYQELIADVFEN 373
            :...:|:.||:  |.::.:|   :.:|...||. :||..: :.:::.:|.:..::...:.:.|.|
 Frog   302 LFSRVPNGLKTMCECMSLYL---REQGKALVSE-EGEGKNPVDYIQGLLDLKSRFDRFLQESFSN 362

  Fly   374 DSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKK--SKTCEAEIDQKLTNNITIFKY 436
            |.||...:.......:|..      .||.||::.:.|..|||  ....|.|::..|...:.:|::
 Frog   363 DRLFKQTIAGDFEYFLNLN------SRSPEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFRF 421

  Fly   437 IEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNK 501
            :::|||::::|.:.||:||:..:|.|.|:|:.||::||..||.:||:||..||.|:|:|....::
 Frog   422 MQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDE 486

  Fly   502 FNTHLKDSNVDL-GINLAIKVLQAGAWPLGSTQV---IPFAVPQEFEKSIKMFEDYYHKLFSGRK 562
            |..||:.:.|.| |::|.::||..|.||..|...   ||.|....||    :|..:|....|||:
 Frog   487 FRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFE----IFRRFYLAKHSGRQ 547

  Fly   563 LTWLHHMCHGELKLSH---LKK-------------------SYIVTMQTYQMAIILLFETCDSLS 605
            ||..|||...:|..:.   :||                   .:|:.:.|:||.|::||...:..:
 Frog   548 LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYT 612

  Fly   606 CREIQNTLQLNDETFQKHMQPIIESK------LLNASSENLAGETRIELNLDYTNK--RTKFKIS 662
            ..|||....:.:....:.:|.:...|      .....|:.:.......:|..:|:|  |.|.:..
 Frog   613 FEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQFTSKLHRVKIQTV 677

  Fly   663 SALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIK 727
            :|.|.|:..|.:.|...||:|||..::||||||||:||.::||.|:.||....|..|.|:..:||
 Frog   678 AAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIK 742

  Fly   728 KCVESLIDKQYIERTANSGDEYSYMA 753
            |.:|.||:::|:.||......|:|:|
 Frog   743 KRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	155/643 (24%)
		CULLIN	436..575	CDD:214545	55/142 (39%)
		Cullin_Nedd8	680..745	CDD:214883	32/64 (50%)
cul3	NP_001015975.2	Cullin	34..665	CDD:366357	161/688 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		7/20 (35%)
		Cullin_Nedd8	695..762	CDD:214883	32/66 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930