Protein Alignment Cul2 and cul4a

DIOPT Version :9

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_001015893.1
• Gene: cul4a / 548647
• XenbaseID: XB-GENE-1014775
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 778
• Identity: 198/778 - (25%)
• Similarity: 378/778 - (48%)
• Gaps: 97/778 - (12%)

  Fly     4 KPKIVEFV--DVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLE 66
            |||:.:..  |.|.:|:....::.:.|.::.:: ...:..|..||..:   ::..||.:.:...|
 Frog    45 KPKLPDSYTQDTWQKLQEAVNAIESSTSIKYNL-EELYQAVENLCSYK---VSHTLYKQLRQVCE 105

  Fly    67 QHVQE-------------MLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLN 118
            :|::.             :..|||   ..|                |.::.:.:..:..::::|:
 Frog   106 EHMKAQIHQFREDSLDSFLFLKKV---NRC----------------WKDHCRQMIMIRSIFLFLD 151

  Fly   119 QQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRAS 181
            :.::.:..:..:                |.::||:::|.:::  ..:..:.:..||:.|..:| |
 Frog   152 RTYVLQNSMLPS----------------IWDMGLELFRCHVVSDRMVQIKTIDGILKLIEQER-S 199

  Fly   182 NGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSE 246
            ...:|...::.:.|::            ..|::|:|.||...||.:...|..|..:|:....|.|
 Frog   200 GEAVDRSLLRSLLGML------------SDLQVYKESFETKFLEETNCLYAAEGQRLMQEREVPE 252

  Fly   247 YMQEVIRILEYESRRAQKFL-HVSSLPKLRKECEEK-FINDRLGFIYSE-CREMVSEERRQDLRN 308
            |:..|.|.||.|..|...:| |.:..|.:  .|.|| .:.:.|..|..: .:.|:.|.|..:|..
 Frog   253 YLHHVNRRLEEEVDRVITYLDHGTHKPLI--ACVEKQLLGEHLTAILQKGLKNMLDENRDPELTL 315

  Fly   309 MYVVLKPIPDNLKSELITTFLDHIKS--EGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVF 371
            ||.:...:... :..|:..:.::||:  .|| .::..|.:::    |:.:|........:|...|
 Frog   316 MYQLFSRVKGG-QIILLQHWGEYIKNFGSGL-VINPEKDKDM----VQELLDFKDNVDHIIDVCF 374

  Fly   372 ENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIF 434
            :.:..|::.:.::..:.||||..     :.||.:|||.|:.|:  ..:..:.|:::.|...:.||
 Frog   375 QKNEKFVNTMKESFETFINRRAN-----KPAELIAKYVDSKLRSGNKEATDEELERLLDKIMIIF 434

  Fly   435 KYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLN 499
            ::|..|||::.||.:.|||||:..:|.|:|:|:.|:::||..||..||:||..||.|:.:|.|:.
 Frog   435 RFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVM 499

  Fly   500 NKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLT 564
            .:|..|:::.:....|:|.:.:|..|.||  :...:...:|.|..|..::|:.:|....|||:|.
 Frog   500 VQFKQHMQNHSDPGNIDLTVNILTMGYWP--TYTPVDVHLPAEMVKLQEIFKAFYLGKHSGRRLQ 562

  Fly   565 WLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPII- 628
            |...:.|..||....::...:.:..:|..::|||...|.....||:.|..:.|...::.:|.:.
 Frog   563 WQSTLGHAVLKADFKEEKKELQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLAC 627

  Fly   629 -ESKLLNAS--SENLAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQA 690
             ::::||.|  |:::....|...|.|:.:|..:.||:....|||.:|..:|...|.:||:..:.|
 Frog   628 GKARVLNKSPKSKDVEDGDRFCFNADFKHKLYRIKINQIQMKETVEEQVNTTERVFQDRQYQIDA 692

  Fly   691 AIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            |||||||.||.|.||.|:.|:.:..|....|  ..:||.:|||||:.|:||..::..:|.|:|
 Frog   693 AIVRIMKMRKTLTHNLLVSELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDNAKQYHYLA 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	147/625 (24%)
		CULLIN	436..575	CDD:214545	48/138 (35%)
		Cullin_Nedd8	680..745	CDD:214883	30/64 (47%)
cul4a	NP_001015893.1	Cullin	58..653	CDD:279260	151/661 (23%)
		CULLIN	436..576	CDD:214545	50/141 (35%)
		Cullin_Nedd8	682..747	CDD:214883	30/66 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010