Protein Alignment Cul2 and Cul5

DIOPT Version :9

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Alignment Length: 866
• Identity: 215/866 - (24%)
• Similarity: 376/866 - (43%)
• Gaps: 148/866 - (17%)

  Fly    10 FVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEMLA 74
            |.:|||..|.|...::....|.:..|...|..|:.:|: ..|..|.::|    ..|:|.:.|.:
  Fly    13 FEEVWPDKRRIVLKLLRQDTVSQREWQDLFFGVHFVCL-WDEKGAAKIY----DCLQQDIVEFI- 71

  Fly    75 KKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKIT----------- 128
              |..:.:.....|...||..|.:.|.::.....||...:..|.|....|...:
  Fly    72 --VQAQSQVQAQRGEQALLATYIVEWRKFFTQSNYLPLPFRQLEQSPQVKPSSSGSSSSASVSAS 134

  Fly   129 ------------------------DTESFYGNLSSDAA--------------------------- 142
                                    .|.:..|..:|.||
  Fly   135 GASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSSAAAAAAASGSGSSSSS 199

  Fly   143 ---------EQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIH 198
                     |...:.:|.||.|..::...:...|....::.:.|:|  ||  |.:..|::.||..
  Fly   200 TSTSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAER--NG--DAYDAQLVVGVRE 260

  Fly   199 SFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQ 263
            |:|.:.. .....|::|:|.||...|:|:..:|..::.:......|..||:.....|..|..||:
  Fly   261 SYVNLSS-NAEDKLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAK 324

  Fly   264 KFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMY---------VVLKPIPDN 319
            ::|..||...|........|.|.|..|.:||..::.:...:.|..|:         |.::|:..:
  Fly   325 RYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHGVGVEPMMGD 389

  Fly   320 LKSELITTFL-DHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDK 383
            |:..:::..| |.:.:..:.|..:.|       :||.:|::.:|:.:|:.:.|.:|..||:|.|.
  Fly   390 LQRHIMSAGLADMLSASEVITQDSEK-------YVERLLELFNKFSDLVRNAFNDDPRFLTARDI 447

  Fly   384 ACASVIN-------RRPTE---------RQPCRSAEYVAKYCDTLLKK---SKTCEAE-IDQKLT 428
            |..:|:|       ..||.         ....:..|.:|.|||.||::   ||...:| ||.:|.
  Fly   448 AFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTPLSKRLTSEQIDARLR 512

  Fly   429 NNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQ-ACGYEFTNKLHRMFTDI 492
            :.:.:.||:.:|||:.:::...|.:|||...|...:.||.::..|:: ....::.|:|.|||.||
  Fly   513 DVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDI 577

  Fly   493 SVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKL 557
            .||.|||.:|.|.:...:   .||  ||:|.||||...|.:| ..::|.|.|..|...|::|.|.
  Fly   578 KVSEDLNTQFRTSISRHD---AIN--IKILNAGAWARCSERV-SVSLPIELEDYIPDVEEFYKKK 636

  Fly   558 FSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLF--ETCDSLSCREIQNTLQLNDETF 620
            .|||||.|.|||.:|.:...:....|.:.:.|:|||::..:  ...|.:|...::...:|.|...
  Fly   637 HSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPEL 701

  Fly   621 QKHMQ-----PIIESKLL------NASSENLAGETRIELNLDY-------TNKRTKFKISSALQK 667
            ::.:.     |.|:.::|      .:|.::.|..|...:|.::       :.:|.|..:...||.
  Fly   702 RRTLWSLVAFPKIKKQILLMEPAAISSPKDFAENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQL 766

  Fly   668 ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVES 732
            .|.:..:....|:.:.|.|..|.||::|||.||.:.:.||..|::.:.|..|.|:..|||:.:|.
  Fly   767 STERSQQEDNQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEW 831

  Fly   733 LIDKQYIERTANSGDEYSYMA 753
            ||:.:|:.|..:..:.:.|:|
  Fly   832 LIENKYMRRDDDDINMFIYVA 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	172/714 (24%)
		CULLIN	436..575	CDD:214545	54/139 (39%)
		Cullin_Nedd8	680..745	CDD:214883	24/64 (38%)
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	177/735 (24%)
		CULLIN	520..655	CDD:214545	54/140 (39%)
		Cullin_Nedd8	779..846	CDD:214883	24/66 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850