DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul1b

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_998660.1	Gene:	cul1b / 406816	ZFINID:	ZDB-GENE-040426-2887	Length:	774	Species:	Danio rerio

Alignment Length:	798	Identity:	283/798 - (35%)
Similarity:	430/798 - (53%)	Gaps:	86/798 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVA-----------------QPEP- 52
            |.:....:|..||...:.|.|...:.||.:...::.||..|.:                 .|.|
Zfish    13 KQIGLEQIWDDLRSGIQQVYTRQSMARSRYMELYTHVYNYCTSVHQARPTGIPSSKPSKKTPTPG 77

  Fly    53 ----MADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIK 108
                :...||...|.||..::..:|             ..|.||     |:.|...|.:|....|
Zfish    78 GAQFVGLELYKRLKDFLRSYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSK 129

  Fly   109 YLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILE 173
            .|..:..|||:..::::.....:..|           ||..|.|..||..:...|:.::...:|:
Zfish   130 VLDGICAYLNRHWVRRECDEGRKGIY-----------EIYSLALATWRECLFRPLNKQVTNAVLK 183

  Fly   174 GIAADRASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTD 233
            .:..:|  ||...:.|  :::||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.
Zfish   184 LVEKER--NGETINTR--LVSGVVQSYVELGLNEDDAFVKGPTLSVYKEYFEAQFLADTERFYTR 244

  Fly   234 EANKLLHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREM 297
            |:.:.|.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.:
Zfish   245 ESTEFLQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNL 308

  Fly   298 VSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTV-----SALKGENIHIAFVENML 357
            :..::.:||..||.::..|.|.| .||......||.::||..:     |||....:   :|:..|
Zfish   309 LDADKNEDLGRMYNLVSRITDGL-GELKKLLESHIHNQGLAAIEKCGDSALNDPKM---YVQTTL 369

  Fly   358 KVHHKYQELIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC 419
            .||.||..|:...|.||:.|::||||||...||.....|   ...:|.|.:|:|||:|||||...
Zfish   370 DVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTRMAQSSSKSPELLARYCDSLLKKSSKN 434

  Fly   420 --EAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFT 482
              |||::..|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|
Zfish   435 PEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYT 499

  Fly   483 NKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSI 547
            :||.|||.||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.
Zfish   500 SKLQRMFQDIGVSKDLNEQFKKHLSNSE-PLDLDFSIQVLSSGSWPF--QQSCTFALPSELERSY 561

  Fly   548 KMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNT 612
            :.|..:|....||||||||:|:..|||..:..|..|.:...|:||||:|.|.|.:..|.:::.::
Zfish   562 QRFTAFYGSRHSGRKLTWLYHLSKGELVTNCFKNRYTLQASTFQMAILLQFNTENCYSVQQLADS 626

  Fly   613 LQLNDETFQKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETP 670
            .|:..:...:.:|.:::||||....||       ...:|.|:|.|.|.||:.:..|:..::.|..
Zfish   627 TQIKTDILVQVLQILLKSKLLVLEDENANIDEMDFKPDTLIKLFLGYKNKKLRVNINVPMKTEQK 691

  Fly   671 QEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLID 735
            ||.|.|..:::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:
Zfish   692 QEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIE 756

  Fly   736 KQYIERTANSGDEYSYMA 753
            |:|:||.....|.|||:|
Zfish   757 KEYLERVDGEKDTYSYLA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	219/642 (34%)
		CULLIN	436..575	CDD:214545	75/138 (54%)
		Cullin_Nedd8	680..745	CDD:214883	36/64 (56%)
cul1b	NP_998660.1	Cullin	22..660	CDD:279260	227/673 (34%)
		CULLIN	453..588	CDD:214545	74/137 (54%)
		Cullin_Nedd8	701..768	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930