DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul2 and AT1G43140

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_175007.2	Gene:	AT1G43140 / 3767291	AraportID:	AT1G43140	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	744	Identity:	185/744 - (24%)
Similarity:	340/744 - (45%)	Gaps:	103/744 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FSDVYTLCVAQ-PEPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWME 102
            ::.:|.:|:.| |...:..||.:.:..::.:.:|.:...:       ....|..:|:.....|..
plant    52 YTIIYDMCLQQPPNDYSQELYNKYRGVVDHYNKETVLPSM-------RERHGEYMLRELVKRWAN 109

  Fly   103 YSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSEL 167
            :...:::|.:...||::.::.::.:.                 .:.::|...:...:.:.:.||.
plant   110 HKILVRWLSRFCFYLDRFYVARRGLP-----------------TLNDVGFTSFHDLVYQEIQSEA 157

  Fly   168 VRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYT 232
            ...:|..|..:|...        ||...::.:.::|......|.:.:|:|.||..:|:.:.:||:
plant   158 KDVLLALIHKEREGE--------QIDRTLVKNVIDVYCGNGVGQMVIYEEDFESFLLQDTASYYS 214

  Fly   233 DEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFI------- 290
            .:|::.....|..:||.:....|:.|..|...:||.::.|||    .||..|:.|..:
plant   215 RKASRWSQEDSCPDYMLKAEECLKLEKERVTNYLHSTTEPKL----VEKVQNELLVVVAKQLIEN 275

  Fly   291 -YSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEG----LQTVSALKGENIHI 350
             :|.|..::.:::..||..||.:.:.||..|: .:...|..|:.:||    .|...|...::...
plant   276 EHSGCLALLRDDKMGDLSRMYRLYRLIPQGLE-PIADLFKQHVTAEGNALIKQAADAATNQDASA 339

  Fly   351 A--FVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLL 413
            :  .|...:::|.||...:.:.|:..|||...|.:|.....|:...   ...|||.:|.|||.:|
plant   340 SQVLVRKEIELHDKYMVYVDECFQKHSLFHKLLKEAFEVFCNKTVA---GASSAEILATYCDNIL 401

  Fly   414 K----KSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLK 474
            |    ..|..:...:..|...:.:..||.|||::.:||.:..|:||:.::|..|
plant   402 KTRGGSEKLSDEATEITLEKVVNLLVYISDKDLFAEFYRKKQARRLLFDRSGIM----------- 455

  Fly   475 QACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK-DSNVDLGINLAIKVLQAGAWPLGSTQVIPFA 538
                        :..|||:::.:|...|..:|. :....|||:..:.||..|.||  |.:.....
plant   456 ------------KEVTDITLARELQTNFVDYLSANMTTKLGIDFTVTVLTTGFWP--SYKTTDLN 506

  Fly   539 VPQEFEKSIKMFEDYYHKLFSGRKLTWLHHM--CH--GELKLSHLKKSYIVTMQTYQMAIILLFE 599
            :|.|....::.|:.:|....:.|:|:|::.:  ||  |:.:    ||:..:.:.|||.|::|||.
plant   507 LPTEMVNCVEAFKVFYGTKTNSRRLSWIYSLGTCHILGKFE----KKTMELVVSTYQAAVLLLFN 567

  Fly   600 TCDSLSCREIQNTLQLNDETFQK--HMQPIIESKLL--NASSENLAGETRIELNLDYTNKRTKFK 660
            ..:.||..||...|.|:.|...:  |....::.|:|  ...|..::.....|.|..:|:|..|.:
plant   568 NAERLSYTEISEQLNLSHEDLVRLLHSLSCLKYKILIKEPMSRTISKTDTFEFNSKFTDKMRKIR 632

  Fly   661 ISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQE-VLSLSKVSFTPNIA 724
            :......|..:.||    .||:||:..:.||:|||||:||||.|..|:.| |..|||: |.|:|.
plant   633 VPLPPMDERKKVVE----DVDKDRRYAIDAALVRIMKSRKVLAHQQLVSECVEHLSKM-FKPDIK 692

  Fly   725 MIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||||.:|.||::.|:||...:.:.:.|:|
plant   693 MIKKRIEDLINRDYLERDTENANTFKYVA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	140/627 (22%)
		CULLIN	436..575	CDD:214545	37/143 (26%)
		Cullin_Nedd8	680..745	CDD:214883	35/65 (54%)
AT1G43140	NP_175007.2	Cullin	48..623	CDD:279260	142/639 (22%)
		CULLIN	428..546	CDD:214545	37/142 (26%)
		Cullin_Nedd8	653..713	CDD:287520	31/60 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830