DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul4a

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001120773.1	Gene:	Cul4a / 361181	RGDID:	1563853	Length:	759	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	190/761 - (24%)
Similarity:	366/761 - (48%)	Gaps:	81/761 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEML--- 73
            |.|.:|....:::.:.|.:..:: ...:..|..||..:..|   .||.:.:...|.|||..:
  Rat    61 DTWRKLHEAVKAIQSSTSIRYNL-EELYQAVENLCSHKVSP---TLYKQLRQVCEDHVQAQILPF 121

  Fly    74 ----AKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFY 134
                ...||             .|::....|.::.:.:..:..::::|::.::.:..:..:
  Rat   122 REDSLDSVL-------------FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPS---- 169

  Fly   135 GNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVI 197
                        |.::||:::|.::|  ..:.|:.:..||..|..:|:...        :...::
  Rat   170 ------------IWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEA--------VDRSLL 214

  Fly   198 HSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRA 262
            .|.:.:     ...|::|::.||...||.:...|..|..:|:....|.||:..|.:.||.|:.|.
  Rat   215 RSLLSM-----LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRV 274

  Fly   263 QKFLHVSSLPKLRKECEEKFINDRLGFIYSE-CREMVSEERRQDLRNMYVVLKPIPDNLKSELIT 326
            ..:|..|:...|....|::.:.:.|..|..: ..:::.|.|..||..||.:...:... :..|:.
  Rat   275 ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGG-QHALLQ 338

  Fly   327 TFLDHIKSEGLQ-TVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVIN 390
            .:.::||:.|.. .::..|.:::    |:::|....|...::...|:.:..|::.:.::..:.||
  Rat   339 HWSEYIKTFGTTIVINPEKDKDM----VQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFIN 399

  Fly   391 RRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAK 453
            :||.     :.||.:||:.|:.|:  ..:..:.|:::.|...:.:|::|..|||::.||.:.|||
  Rat   400 KRPN-----KPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAK 459

  Fly   454 RLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLA 518
            ||:..:|.|:|||:.|:::||..||..||:||..||.|:.:|.|:...|..|:::.:....|:|.
  Rat   460 RLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLT 524

  Fly   519 IKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELK--LSHLKK 581
            :.:|..|.||..:...:  .:|.|..:..::|:.:|....|||||.|...:.|..||  ....||
  Rat   525 VNILTMGYWPTYTPMEV--HLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKK 587

  Fly   582 SYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESK----LLNASSENLAG 642
            .:.|::  :|..::|:|...|..|..||:....:.|...::.:|.:...|    :.:...:.:..
  Rat   588 EFQVSL--FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVED 650

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            ..:...|.|:.:|..:.||:....|||.:|...|...|.:||:..:.||||||||.||.|.||.|
  Rat   651 GDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            :.|:.:..|....|  ..:||.:|||||:.|:||..:|.::|.|:|
  Rat   716 VSELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	142/618 (23%)
		CULLIN	436..575	CDD:214545	49/138 (36%)
		Cullin_Nedd8	680..745	CDD:214883	30/64 (47%)
Cul4a	NP_001120773.1	Cullin	63..660	CDD:395716	146/656 (22%)
Cul4a	NP_001120773.1	Cullin_Nedd8	688..753	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830