DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul4

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001163084.1	Gene:	Cul4 / 35780	FlyBaseID:	FBgn0033260	Length:	821	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	209/754 - (27%)
Similarity:	378/754 - (50%)	Gaps:	77/754 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IAESVIT--LTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQEMLAKKVLIEGE 82
            :.|:||.  |:|..:......:..|..:|   ...|..:||.:.|...||||:..:..|.|
  Fly   125 LEEAVIAIQLSKPIKYSLEELYQAVVNMC---SHKMDAQLYAKLKELTEQHVKRNIKLKEL---- 182

  Fly    83 CSHSNGGPD---LLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQ 144
               :.|..|   ||::....|:.:.|.:..:..:::|:::.::.:.....:
  Fly   183 ---TGGSMDKLILLEKINHWWLSFCQQMIMIRSIFLYMDRTYVLQNSTVHS-------------- 230

  Fly   145 MEIGELGLDIWRLYMIEYLSSELVRHILEGIAA--DRASNG-TLDHHRVQIINGVIHSFVEVQDY 206
              |.::|||::|::..:  :|.:.:..::|:..  ::...| |:|       .|::.|.|
  Fly   231 --IWDMGLDLFRIHFAQ--NSVVQKRTVDGLLTLIEKERQGSTVD-------RGLLKSLV----- 279

  Fly   207 KKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSL 271
            :....|::|...||...|:|:...|..|:.:.:....|.||:|.|.:.|..|:.|.:.:|..|:.
  Fly   280 RMLCDLQIYTSSFEEKFLDATNQLYKAESQRKMQELEVPEYLQHVNKRLAEENERLRHYLDSSTK 344

  Fly   272 PKLRKECEEKFINDRLGFIYSECREMVSEERR-QDLRNMYVVLKPIPDNLKSELITTFLDHIKSE 335
            ..|....|::.:.:.|..|..:..:.:.|:.| .||..:|.:|..: .|..|||...|...||.:
  Fly   345 HPLIYNVEKELLAEHLTSILQKGLDSLLEDNRLSDLTLLYGLLSRV-KNGTSELCGNFNGFIKKK 408

  Fly   336 GLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCR 400
            |...|...:.:.   :.|:::|....|...::...||::..|.::|.:|....||:|..     :
  Fly   409 GRTIVIDPEKDK---SMVQDLLDFKDKMDVIVRTCFEHNEKFTNSLREAFEFFINQRAN-----K 465

  Fly   401 SAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSM 463
            .||.:|||.|..|:...  |.:.|:::.|...:.:|::|..|||::.||.:.|||||:..:|.|:
  Fly   466 PAELIAKYVDMKLRSGNKGTTDEELEKTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASV 530

  Fly   464 DAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDL-GINLAIKVLQAGAW 527
            |:|:.|:::|||.||..||:||..||.|:.:|.|:|..|..|...:|.|: .::|.:.:|..|.|
  Fly   531 DSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYW 595

  Fly   528 P-LGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHM--CHGELKLSHLKKSYIVTMQT 589
            | ...|:|   .:|.:|....::|..:|.:..|||||.|...:  |....:.....|..:|::
  Fly   596 PTYAPTEV---TMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSL-- 655

  Fly   590 YQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPII--ESKLLNAS---SENLAGETRIELN 649
            :|..::|||.....||..||.....:.|...::.:|.:.  .::::..:   .|.|.|: :.:.|
  Fly   656 FQALVLLLFNDKPVLSYEEILAATLIEDGELRRTLQSLACGRARVITKTPKGREILDGD-QFDFN 719

  Fly   650 LDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSL 714
            .::|||..:.||:....|||.:|.:.|...|.:||:..:.||||||||.||.|.||.||.|:  .
  Fly   720 NEFTNKLFRIKINQIQMKETNEEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITEL--F 782

  Fly   715 SKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ::::|....|.:||.:|||||:.|:||..::.::|:|:|
  Fly   783 NQLTFPVKPADLKKRIESLIDRDYMERDKDNQNQYNYVA 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	156/617 (25%)
		CULLIN	436..575	CDD:214545	53/142 (37%)
		Cullin_Nedd8	680..745	CDD:214883	31/64 (48%)
Cul4	NP_001163084.1	Cullin	124..721	CDD:279260	165/650 (25%)
		CULLIN	503..644	CDD:214545	53/143 (37%)
		Cullin_Nedd8	750..815	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850