DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul1

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	265/792 - (33%)
Similarity:	425/792 - (53%)	Gaps:	73/792 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIVEFVDVWPRLRCIAESVITLTKVERSVWNTS----FSDVYTLCV---AQP-----------EP 52
            |:|...|:|..|   .|.::.:.:.|:|:..:.    ::.||..|.   |.|           :.
  Fly    12 KLVNLDDIWSEL---VEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQL 73

  Fly    53 MADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYL 117
            :..:||...:.||:.::.|:|.|...|.||       ..||.||...|..|......|..:..||
  Fly    74 VGKKLYDRLEQFLKSYLSELLTKFKAISGE-------EVLLSRYTKQWKSYQFSSTVLDGICNYL 131

  Fly   118 NQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASN 182
            |:..:|::.....:..|           :|..|.|..|:.::.:.|:..:.:.:|:.|..:|  .
  Fly   132 NRNWVKRECEEGQKGIY-----------KIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEER--Q 183

  Fly   183 GTLDHHRVQIINGVIHSFVEVQ------DYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHR 241
            |.|.:.  .::..||..:||:.      |.::. .|.:|::.||...:..:.|:|..|::..|..
  Fly   184 GKLINR--SLVRDVIECYVELSFNEEDTDAEQQ-KLSVYKQNFENKFIADTSAFYEKESDAFLST 245

  Fly   242 CSVSEYMQEVIRILEYESRRAQKF--------LHVSSLPKLRKECEEKFINDRLGFIYSECREMV 298
            .:|:||::.|...||.|::|.:.|        ||.::...|:..|||..|...|...::|.:.::
  Fly   246 NTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLL 310

  Fly   299 SEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVS---ALKGENIHIAFVENMLKVH 360
            :.:|..||:.||.::.....|| ::|.:...:||..:|.:.::   .....|....:|:.:|.||
  Fly   311 NADRNDDLKRMYSLVALSSKNL-TDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVH 374

  Fly   361 HKYQELIADVFENDSLFLSALDKACASVINRR--PTERQPCRSAEYVAKYCDTLLKKSKTC--EA 421
            .||..|:...|.||:.|::||||||...||..  .......:|.|.:|||||.|||||...  :.
  Fly   375 KKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDK 439

  Fly   422 EIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLH 486
            |::..|...:.:|||||||||:||:||::|||||::..|.|.|||..||::|||.||||:|.||.
  Fly   440 ELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQ 504

  Fly   487 RMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFE 551
            |||.||.||.|||:.|..:|.:.|:.:.|:..|:||.:|:||...:.  .|.:|.|.|:|::.|.
  Fly   505 RMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSN--NFLLPSELERSVRQFN 567

  Fly   552 DYYHKLFSGRKLTWLHHMCHGELKLS---HLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTL 613
            ::|....|||||.||:.||.|||.::   :...:|.:...|:||:::|.|....|.:.:::|:..
  Fly   568 EFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNT 632

  Fly   614 QLNDETFQKHMQPIIESKLLNAS-SEN-LAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHT 676
            |...|...:.:|.::::|:|.:| :|| |..|:.:||.|||.||:.:..|:..|:.|...|.|..
  Fly   633 QTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETV 697

  Fly   677 INSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIER 741
            ...::|||||.:|||||||||.||.|.|..||.|||:.....|.|.:.:||||::.||:|:|:||
  Fly   698 HKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLER 762

  Fly   742 TANSGDEYSYMA 753
            .....|.|||:|
  Fly   763 MEGHKDTYSYLA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	201/638 (32%)
		CULLIN	436..575	CDD:214545	71/138 (51%)
		Cullin_Nedd8	680..745	CDD:214883	35/64 (55%)
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	209/676 (31%)
		CULLIN	454..593	CDD:214545	72/140 (51%)
		Cullin_Nedd8	701..765	CDD:214883	35/63 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467936
Domainoid	1	1.000	60	1.000	Domainoid score	I2560
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46807
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850