DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul3

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_723909.2	Gene:	Cul3 / 34896	FlyBaseID:	FBgn0261268	Length:	934	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	205/822 - (24%)
Similarity:	380/822 - (46%)	Gaps:	140/822 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLKPKIVEFVDVWPRLRCIAESV-------ITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYG 59
            |:..|.||  .:|..|:...:.:       ::..::.|:.:|...           ....:|||.
  Fly   183 SMDEKYVE--TIWASLKNAIQEIQKKNNSGLSFEQLYRNAYNMVL-----------HKHGNRLYY 234

  Fly    60 ETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKK 124
            ..:..:.:|::..:...||   |..|||..|.|.|    .|.::...:..:..:.:|:::.::::
  Fly   235 GLREVVSEHLEHKVRADVL---EALHSNFLPKLNQ----AWTDHQTSMVMIRDILMYMDRVYVQQ 292

  Fly   125 QKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSEL---VRHILEGIAADRASNGTLD 186
            :::.:                 :..|||.::|..::.|  ||:   :|..|.|:..:......::
  Fly   293 REVDN-----------------VYNLGLILFRDQVVRY--SEIQKALREKLLGMVMEERHGEAIN 338

  Fly   187 HHRVQ------IINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVS 245
            |..::      |..|:             .|..:|:|.||.|.|..|.|:|..|:...|...:..
  Fly   339 HLAIKNACSMLITLGI-------------NSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAG 390

  Fly   246 EYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRL---------GFIYSECREMVSEE 301
            .|:::|...:..||.||..:|...:.|::.:..||:.|...:         |.:|     |:...
  Fly   391 VYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVY-----MIKNS 450

  Fly   302 RRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIH-IAFVENMLKVHHKYQE 365
            :.:||...|.:...:.:.....:..|...:::.:|...|...:..|.: |.||:|:|.:..::.:
  Fly   451 KTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKEEENGNTNPITFVQNLLDLKDRFDQ 515

  Fly   366 LIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKK--SKTCEAEIDQKLT 428
            .:...|.||.:|.:.:.......:|...      :|.||::.:.|..|||  ....|.||:..|.
  Fly   516 FLVHSFANDRIFKNVISSDFEHFLNLNN------KSPEYLSLFIDDKLKKGGKGMSEQEIESILD 574

  Fly   429 NNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDIS 493
            ..:.:|:::.:|||::::|...|||||:..:|.|.|.|:.||::||..||.:||:||..||.|:|
  Fly   575 KTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMS 639

  Fly   494 VSVDLNNKFNTHLKDSNVDL-GINLAIKVLQAGAWPLGSTQV------IPFAVPQEFEKSIKMFE 551
            ||..:.::|...:.::|:.| |:.|.:::|..|.||   ||.      || |.|:|   :..:|:
  Fly   640 VSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWP---TQTATPNCNIP-AAPRE---AFDIFK 697

  Fly   552 DYYHKLFSGRKLT--------WLHHMCHGELKLSHLK------------------KSYIVTMQTY 590
            ::|....|||:||        :::.:.:|...:...|                  :.:|:.:.||
  Fly   698 NFYLNKHSGRQLTLQPQMGTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTY 762

  Fly   591 QMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESK----LL----NASSENLAGETRIE 647
            ||.::|||...|.|:..:|.....:.:....:.:|.:...|    ||    ...::::.......
  Fly   763 QMCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFY 827

  Fly   648 LNLDYTNKRTKFKISSALQK-ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEV 711
            :|..:.:|..:.||.:...| |:..|.:.|...||||||..::|||||||||||.|.||.|:.:|
  Fly   828 VNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDV 892

  Fly   712 LSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .|..|..|.|:...|||.:|.||:::|::|:......|:|:|
  Fly   893 TSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	152/661 (23%)
		CULLIN	436..575	CDD:214545	53/153 (35%)
		Cullin_Nedd8	680..745	CDD:214883	34/64 (53%)
Cul3	NP_723909.2	Cullin	196..831	CDD:279260	156/702 (22%)
		CULLIN	582..724	CDD:214545	52/148 (35%)
		Cullin_Nedd8	866..926	CDD:287520	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850