DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul2

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_002666627.1	Gene:	cul2 / 336088	ZFINID:	ZDB-GENE-030131-8032	Length:	745	Species:	Danio rerio

Alignment Length:	761	Identity:	380/761 - (49%)
Similarity:	530/761 - (69%)	Gaps:	24/761 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65
            |||||::|:|.:.|.:|.....:|:.|..|||:.||..|||:|.||||.|||:.::||.|||.||
Zfish     1 MSLKPRVVDFDETWNKLLTTIRAVVMLDYVERATWNDRFSDIYALCVAYPEPLGEKLYTETKVFL 65

  Fly    66 EQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDT 130
            |.||:: |.|:||...|        .:|..|:..|.|||:|.:|:..||.|||.|.|||.|:|:.
Zfish    66 ENHVRQ-LFKRVLESEE--------KVLVMYHRYWEEYSKGAEYMDCLYRYLNTQFIKKNKLTEA 121

  Fly   131 ESFYGNLSSDAAEQ-MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIIN 194
            :..||....|..|. ||||||.||:||..|||.|...|:..:|:.|..||..    :....::|:
Zfish   122 DLQYGYGGVDMNEPLMEIGELALDMWRKLMIEPLQPMLIGKLLKEIKNDRCG----EDPNQKVIH 182

  Fly   195 GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYES 259
            |||:|||.|:.|||...||.|||:||||.|..:|.||..||:.||...:.|:||::|:..|:.|.
Zfish   183 GVINSFVHVEQYKKKFPLKFYQEIFEGPFLTKTGEYYKQEASNLLQESNCSQYMEKVLGRLKDEE 247

  Fly   260 RRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSEL 324
            .|.:|:||.||..|:..||:::.:.|.|.|::.||:.::.:|:|.|:.|||.:|:.:...| ..:
Zfish   248 VRCRKYLHPSSYSKVIHECQQRMVADHLQFLHGECQNIIRQEKRDDMANMYTLLRAVSSGL-PHM 311

  Fly   325 ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVI 389
            |.....||..||::....|..||:...|||::|:||.|:.:||..|...|..|:||||||..||:
Zfish   312 IQELQVHIHDEGIRATINLSQENMPTLFVESVLEVHSKFVQLINTVLNGDQHFMSALDKALTSVV 376

  Fly   390 N-RRPTERQPCRSAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLL 451
            | |.|  :..|::.|.:|||||.|||||.  ..|.|::.|||:.||:||||:||||:||.|:|:|
Zfish   377 NYREP--KSICKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKIYARML 439

  Fly   452 AKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK--DSNVDLG 514
            ||||||..|.|||:||.|||:||||||||||:|||||:||:|||.|||||||..:|  ::.||||
Zfish   440 AKRLIHGLSLSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSTDLNNKFNNFIKTQETVVDLG 504

  Fly   515 INLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL 579
            |:..|.|||||||||.......||:|||.|||::|||.:|::.||||||||||::|.||:|:::|
Zfish   505 ISFQIYVLQAGAWPLTHVPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYLCTGEVKMNYL 569

  Fly   580 KKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLL--NASSENLAG 642
            .|.|:..:.|||||::|.|...:::|.:|:|::.|:|::..||.::.:::.|::  :...|.:..
Zfish   570 SKPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKEEIEP 634

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNAL 707
            |:...|.:.:|:|||||||::::||:||||:|.|.::||||||::|||||||||||||||:||||
Zfish   635 ESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNAL 699

  Fly   708 IQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||||::.||..|.|:|:|||||:|.|||||||||:.:|.|||||:|
Zfish   700 IQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	289/607 (48%)
		CULLIN	436..575	CDD:214545	94/140 (67%)
		Cullin_Nedd8	680..745	CDD:214883	49/64 (77%)
cul2	XP_002666627.1	Cullin	15..640	CDD:307166	299/640 (47%)
cul2	XP_002666627.1	Cullin_Nedd8	672..739	CDD:214883	50/66 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581271
Domainoid	1	1.000	567	1.000	Domainoid score	I221
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2662
Inparanoid	1	1.050	730	1.000	Inparanoid score	I598
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0007132
OrthoInspector	1	1.000	-	-		oto40309
orthoMCL	1	0.900	-	-		OOG6_106096
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5314
SonicParanoid	1	1.000	-	-		X5228
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940