DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul1a

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_955953.2	Gene:	cul1a / 323883	ZFINID:	ZDB-GENE-030131-2603	Length:	777	Species:	Danio rerio

Alignment Length:	794	Identity:	281/794 - (35%)
Similarity:	431/794 - (54%)	Gaps:	89/794 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVA--------------------QPEP----- 52
            :|..||...:.|.|...:.:|.:...::.||..|.:                    .|.|
Zfish    20 IWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGGAQF 84

  Fly    53 MADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIKYLHQ 112
            :...||...|.||:.::..:|             ..|.||     |:.|...|.:|....|.|:.
Zfish    85 VGLELYKRLKEFLKNYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSKVLNG 136

  Fly   113 LYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAA 177
            :..|||:..::::.....:..|           ||..|.|..||..:...|:.::...:|:.|..
Zfish   137 ICAYLNRHWVRRECDEGRKGIY-----------EIYSLALVTWRECLFRPLNKQVTNAVLKLIEK 190

  Fly   178 DRASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTDEANK 237
            :|  ||...:.|  :|:||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.|:.:
Zfish   191 ER--NGETINTR--LISGVVQSYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTE 251

  Fly   238 LLHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEE 301
            .|.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.::..:
Zfish   252 FLQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDAD 315

  Fly   302 RRQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTV-----SALKGENIHIAFVENMLKVHH 361
            :.:||..||.::..|.|.| .||......||.::||..:     |||....:   :|:.:|.||.
Zfish   316 KNEDLGRMYNLVSRITDGL-GELKKLLETHIYNQGLAAIEKCGESALNDPKM---YVQTILDVHK 376

  Fly   362 KYQELIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC--EA 421
            ||..|:...|.||:.|::||||||...||.....:   ...:|.|.:|:|||:|||||...  ||
Zfish   377 KYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEA 441

  Fly   422 EIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLH 486
            |::..|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|:||.
Zfish   442 ELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQ 506

  Fly   487 RMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFE 551
            |||.||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.:.|.
Zfish   507 RMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPF--QQSCTFALPSELERSYQRFT 568

  Fly   552 DYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLN 616
            .:|....||||||||:|:..|||..:..|..|.:...|:||||:|.:.|.|..:.:::.::.|:.
Zfish   569 AFYASRHSGRKLTWLYHLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDVYTVQQLTDSTQIK 633

  Fly   617 DETFQKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETPQEVE 674
            .:...:.:|.:::||||....||       ...:|.|:|.|.|.||:.:..|:..::.|..||.|
Zfish   634 IDILVQVLQILLKSKLLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNINVPMKTEQKQEQE 698

  Fly   675 HTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYI 739
            .|..:::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:|:|:
Zfish   699 TTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYL 763

  Fly   740 ERTANSGDEYSYMA 753
            ||.....|.|||:|
Zfish   764 ERVDGEKDTYSYLA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	219/645 (34%)
		CULLIN	436..575	CDD:214545	75/138 (54%)
		Cullin_Nedd8	680..745	CDD:214883	36/64 (56%)
cul1a	NP_955953.2	Cullin	22..661	CDD:307166	226/674 (34%)
cul1a	NP_955953.2	Cullin_Nedd8	704..771	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830