Protein Alignment Cul2 and Cul4b

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_001100421.1
• Gene: Cul4b / 302502
• RGDID: 1564494
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 770
• Identity: 200/770 - (25%)
• Similarity: 377/770 - (48%)
• Gaps: 81/770 - (10%)

  Fly     4 KPKIVE-FVD-VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLE 66
            |||:.| :.| .|.:|:...|::...|.::.:: ...:..|..||..:   ::..||.:.:...|
  Rat   263 KPKLPENYTDETWQKLKEAVEAIQNSTSIKYNL-EELYQAVENLCSYK---ISANLYKQLRQICE 323

  Fly    67 QHVQEMLAK-------KVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKK 124
            .|::..:.:       .||             .|::....|..:.:.:..:..::::|::.::.:
  Rat   324 DHIKAQIHQFREDSLDSVL-------------FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ 375

  Fly   125 QKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMI--EYLSSELVRHILEGIAADRASNGTLDH 187
            ..:..:                |.::||:::|.::|  :.:.::.:..||  :..:|..||.
  Rat   376 NSMLPS----------------IWDMGLELFRAHIISDQKVQTKTIDGIL--LLIERERNGE--- 419

  Fly   188 HRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVI 252
               .|...::.|.:.:     ...|::||:.||...|:.:...|..|..||:....|.||:..|.
  Rat   420 ---AIDRSLLRSLLNM-----LSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVN 476

  Fly   253 RILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSE-CREMVSEERRQDLRNMYVVLKPI 316
            :.||.|:.|...:|..::...|....|::.:.:.|..|..: ...::.|.|.|||..:|.:...:
  Rat   477 KRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRV 541

  Fly   317 PDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSAL 381
            ...:: .|:..::::||:.|...|...:.:.   ..|:.:|....|...:|...|..:..|::|:
  Rat   542 RGGVQ-VLLQHWIEYIKAFGSTIVINPEKDK---TMVQELLDFKDKVDHIIDTCFLKNEKFINAM 602

  Fly   382 DKACASVINRRPTERQPCRSAEYVAKYCDTLLK--KSKTCEAEIDQKLTNNITIFKYIEDKDVYQ 444
            .:|..:.||:||.     :.||.:|||.|:.|:  ..:..:.|:::.|...:.||::|..|||::
  Rat   603 KEAFETFINKRPN-----KPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFE 662

  Fly   445 KFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDS 509
            .||.:.|||||:..:|.|:|||:.|:::||..||..||:||..||.|:.:|.|:..:|..::::.
  Rat   663 AFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQ 727

  Fly   510 NVDLGINLAIKVLQAGAWPLGSTQVIPFAV--PQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHG 572
            ||...|.|.:.:|..|.||    ..:|..|  |.|..|..::|:.:|....|||||.|...:.|.
  Rat   728 NVPGNIELTVNILTMGYWP----TYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHC 788

  Fly   573 ELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPII--ESKLL-- 633
            .||....:....:.:..:|..::|:|...:..|..||:....:.|...::.:|.:.  ::::|
  Rat   789 VLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAK 853

  Fly   634 NASSENLAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKA 698
            |...:::....:...|.|:.:|..:.||:....|||.:|...|...|.:||:..:.||||||||.
  Rat   854 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKM 918

  Fly   699 RKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            ||.|.||.|:.||.:..|....|  |.:||.:|||||:.|:||...:.::|:|:|
  Rat   919 RKTLSHNLLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYNYIA 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	151/655 (23%)
		Cullin_Nedd8	683..745	CDD:463146	31/61 (51%)
Cul4b	NP_001100421.1	Cullin	275..872	CDD:459983	151/655 (23%)
		Cullin_Nedd8	903..963	CDD:463146	31/61 (51%)