Protein Alignment Cul2 and Cul1

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_036172.1
• Gene: Cul1 / 26965
• MGIID: 1349658
• Length: 776
• Species: Mus musculus
• Alignment Length: 791
• Identity: 280/791 - (35%)
• Similarity: 430/791 - (54%)
• Gaps: 84/791 - (10%)

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADR--------------------- 56
            :|..||...:.|.|...:.:|.:...::.||..|.:..:....|
Mouse    20 IWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFV 84

  Fly    57 ---LYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIKYLHQL 113
               ||...|.||:.::..:|             ..|.||     |:.|...|.:|....|.|:.:
Mouse    85 GLELYKRLKEFLKNYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSKVLNGI 136

  Fly   114 YIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAAD 178
            ..|||:..::::.....:..|           ||..|.|..||..:...|:.::...:|:.|..:
Mouse   137 CAYLNRHWVRRECDEGRKGIY-----------EIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKE 190

  Fly   179 RASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTDEANKL 238
            |  ||...:.|  :|:||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.|:.:.
Mouse   191 R--NGETINTR--LISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEF 251

  Fly   239 LHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEER 302
            |.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.::..::
Mouse   252 LQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADK 315

  Fly   303 RQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGE---NIHIAFVENMLKVHHKYQ 364
            .:||..||.::..|.|.| .||......||.::||..:... ||   |....:|:.:|.||.||.
Mouse   316 NEDLGRMYNLVSRIQDGL-GELKKLLETHIHNQGLAAIEKC-GEAALNDPKMYVQTVLDVHKKYN 378

  Fly   365 ELIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC--EAEID 424
            .|:...|.||:.|::||||||...||.....:   ...:|.|.:|:|||:|||||...  |||::
Mouse   379 ALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELE 443

  Fly   425 QKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMF 489
            ..|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|:||.|||
Mouse   444 DTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF 508

  Fly   490 TDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYY 554
            .||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.:.|..:|
Mouse   509 QDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPF--QQSCTFALPSELERSYQRFTAFY 570

  Fly   555 HKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDET 619
            ....||||||||:.:..|||..:..|..|.:...|:||||:|.:.|.|:.:.:::.::.|:..:.
Mouse   571 ASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDI 635

  Fly   620 FQKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTI 677
            ..:.:|.:::||||....||       |..:|.|:|.|.|.||:.:..|:..::.|..||.|.|.
Mouse   636 LAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTH 700

  Fly   678 NSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERT 742
            .:::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:|:|:||.
Mouse   701 KNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERV 765

  Fly   743 ANSGDEYSYMA 753
            ....|.|||:|
Mouse   766 DGEKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	230/687 (33%)
		Cullin_Nedd8	683..745	CDD:463146	35/61 (57%)
Cul1	NP_036172.1	Cullin	21..660	CDD:459983	225/672 (33%)
		Cullin_Nedd8	706..768	CDD:463146	35/61 (57%)