DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul1

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001342479.1	Gene:	Cul1 / 26965	MGIID:	1349658	Length:	776	Species:	Mus musculus

Alignment Length:	791	Identity:	280/791 - (35%)
Similarity:	430/791 - (54%)	Gaps:	84/791 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADR--------------------- 56
            :|..||...:.|.|...:.:|.:...::.||..|.:..:....|
Mouse    20 IWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFV 84

  Fly    57 ---LYGETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDL-----LQRYYITWMEYSQGIKYLHQL 113
               ||...|.||:.::..:|             ..|.||     |:.|...|.:|....|.|:.:
Mouse    85 GLELYKRLKEFLKNYLTNLL-------------KDGEDLMDESVLKFYTQQWEDYRFSSKVLNGI 136

  Fly   114 YIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAAD 178
            ..|||:..::::.....:..|           ||..|.|..||..:...|:.::...:|:.|..:
Mouse   137 CAYLNRHWVRRECDEGRKGIY-----------EIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKE 190

  Fly   179 RASNGTLDHHRVQIINGVIHSFVEV---QD--YKKTGSLKLYQELFEGPMLEASGAYYTDEANKL 238
            |  ||...:.|  :|:||:.|:||:   :|  :.|..:|.:|:|.||...|..:..:||.|:.:.
Mouse   191 R--NGETINTR--LISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEF 251

  Fly   239 LHRCSVSEYMQEV-IRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEER 302
            |.:..|:|||::. .|:|| |.||.|.:||.|:..:|.::||:..|...|...::|.:.::..::
Mouse   252 LQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADK 315

  Fly   303 RQDLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGE---NIHIAFVENMLKVHHKYQ 364
            .:||..||.::..|.|.| .||......||.::||..:... ||   |....:|:.:|.||.||.
Mouse   316 NEDLGRMYNLVSRIQDGL-GELKKLLETHIHNQGLAAIEKC-GEAALNDPKMYVQTVLDVHKKYN 378

  Fly   365 ELIADVFENDSLFLSALDKACASVINRRPTER---QPCRSAEYVAKYCDTLLKKSKTC--EAEID 424
            .|:...|.||:.|::||||||...||.....:   ...:|.|.:|:|||:|||||...  |||::
Mouse   379 ALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELE 443

  Fly   425 QKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMF 489
            ..|...:.:|||||||||:||||:::|||||:|:.|.|.|||..||::||||||:|:|:||.|||
Mouse   444 DTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMF 508

  Fly   490 TDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYY 554
            .||.||.|||.:|..||.:|. .|.::.:|:||.:|:||.  .|...||:|.|.|:|.:.|..:|
Mouse   509 QDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPF--QQSCTFALPSELERSYQRFTAFY 570

  Fly   555 HKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDET 619
            ....||||||||:.:..|||..:..|..|.:...|:||||:|.:.|.|:.:.:::.::.|:..:.
Mouse   571 ASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDI 635

  Fly   620 FQKHMQPIIESKLLNASSEN-------LAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTI 677
            ..:.:|.:::||||....||       |..:|.|:|.|.|.||:.:..|:..::.|..||.|.|.
Mouse   636 LAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTH 700

  Fly   678 NSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERT 742
            .:::|||||.:|||||||||.||||||..|:.|||:.....|.|.:.:||||::.||:|:|:||.
Mouse   701 KNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERV 765

  Fly   743 ANSGDEYSYMA 753
            ....|.|||:|
Mouse   766 DGEKDTYSYLA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	217/642 (34%)
		CULLIN	436..575	CDD:214545	74/138 (54%)
		Cullin_Nedd8	680..745	CDD:214883	36/64 (56%)
Cul1	NP_001342479.1	Cullin	21..660	CDD:395716	225/672 (33%)
Cul1	NP_001342479.1	Cullin_Nedd8	706..767	CDD:402267	35/60 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830