DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and Cul3

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	806	Identity:	208/806 - (25%)
Similarity:	382/806 - (47%)	Gaps:	113/806 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTS-------FSDVYTLCVAQPEPMADRLY 58
            |::..|.|.  .:|..|:      ..:.:::|.  |.|       :.:.||:.:   ....::||
Mouse    23 MTMDEKYVN--SIWDLLK------NAIQEIQRK--NNSGLSFEELYRNAYTMVL---HKHGEKLY 74

  Fly    59 GETKHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIK 123
            ...:..:.:|:...:.:.||       ::...:.||.....|.::...:..:..:.:|:::.:::
Mouse    75 TGLREVVTEHLINKVREDVL-------NSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ 132

  Fly   124 KQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEY--LSSELVRHILEGIAADRASNGTLD 186
            :..:   |:.|              .|||.|:|..::.|  :...|.:.:|:.||.:|
Mouse   133 QNNV---ENVY--------------NLGLIIFRDQVVRYGCIRDHLRQTLLDMIARER------- 173

  Fly   187 HHRVQIIN-GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQE 250
              :.:::: |.|.:..::..........:|:|.||.|.||.|..::..|:.|.|...|.|.|:::
Mouse   174 --KGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236

  Fly   251 VIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIY----SECREMVSEERRQDLRNMYV 311
            |...:..|..|....|..|:...:.|..|.:.|:..:..|.    |....|:...:.:||..||.
Mouse   237 VEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYK 301

  Fly   312 VLKPIPDNLKS--ELITTFLDHIKSEGLQTVSALKGENIH-IAFVENMLKVHHKYQELIADVFEN 373
            :...:|:.||:  |.::.:|   :.:|...||. :||..: :.:::.:|.:..::...:.:.|.|
Mouse   302 LFSRVPNGLKTMCECMSCYL---REQGKALVSE-EGEGKNPVDYIQGLLDLKSRFDRFLQESFNN 362

  Fly   374 DSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKK--SKTCEAEIDQKLTNNITIFKY 436
            |.||...:.......:|..      .||.||::.:.|..|||  ....|.|::..|...:.:|::
Mouse   363 DRLFKQTIAGDFEYFLNLN------SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRF 421

  Fly   437 IEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNK 501
            :::|||::::|.:.||:||:..:|.|.|:|:.||::||..||.:||:||..||.|:|:|....::
Mouse   422 MQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDE 486

  Fly   502 FNTHLKDSNVDL-GINLAIKVLQAGAWPLGSTQV---IPFAVPQEFEKSIKMFEDYYHKLFSGRK 562
            |..||:.:.|.| |::|.::||..|.||..|...   ||.|....||    :|..:|....|||:
Mouse   487 FRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFE----IFRRFYLAKHSGRQ 547

  Fly   563 LTWLHHMCHGELKLSH---LKK-------------------SYIVTMQTYQMAIILLFETCDSLS 605
            ||..|||...:|..:.   :||                   .:|:.:.|:||.|::||...:..:
Mouse   548 LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYT 612

  Fly   606 CREIQNTLQLNDETFQKHMQPIIESK------LLNASSENLAGETRIELNLDYTNK--RTKFKIS 662
            ..|||....:.:....:.:|.:...|      .....|:.:.......:|..:|:|  |.|.:..
Mouse   613 FEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTV 677

  Fly   663 SALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIK 727
            :|.|.|:..|.:.|...||:|||..::||||||||:||.::||.|:.||....|..|.|:..:||
Mouse   678 AAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIK 742

  Fly   728 KCVESLIDKQYIERTANSGDEYSYMA 753
            |.:|.||:::|:.||......|:|:|
Mouse   743 KRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	155/643 (24%)
		CULLIN	436..575	CDD:214545	55/142 (39%)
		Cullin_Nedd8	680..745	CDD:214883	32/64 (50%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41		5/25 (20%)
		Cullin	35..664	CDD:279260	160/686 (23%)
		CULLIN	421..563	CDD:214545	56/145 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		7/20 (35%)
		Cullin_Nedd8	700..760	CDD:287520	28/59 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820