DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul3

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_592949.1	Gene:	cul3 / 2542637	PomBaseID:	SPAC24H6.03	Length:	785	Species:	Schizosaccharomyces pombe

Alignment Length:	805	Identity:	210/805 - (26%)
Similarity:	368/805 - (45%)	Gaps:	98/805 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VEFVDVWPRL-RCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFLEQHVQE 71
            |:|...|..| |.|.:.      .::|....||.::|.....    :....|||.   |..|||:
pombe    20 VDFATHWEVLQRAIGDI------FQKSTSQLSFEELYRNAYI----LVLHKYGEK---LYNHVQD 71

  Fly    72 MLAKKVLIEG-ECSHSNGGPDLL----------QRYYITWMEYSQGIKYLHQ-LYIYLN--QQHI 122
            ::..::..|. ...:.|....||          ..|..:|   |:.::..|: |...:|  :.||
pombe    72 VIRSRLKEETVPAIYKNYDASLLGNALLDIRKNDSYSTSW---SRSLEAAHRFLSSLVNSWKDHI 133

  Fly   123 -KKQKITDTESFYGNLSSDAAEQMEIGELGLDIWR----LYMIEYLSSELVRHILEGIAADRASN 182
             ..|.|:....:...:.|.:|:::.:.|.|:.|:|    |...| :..:.|..||..:..:|..|
pombe   134 VSMQMISSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFE-IGEKCVETILILVYLERKGN 197

  Fly   183 GTLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEY 247
             |::...:.....:::| :..::.|:|    ||..||....|..:..:|..|::.::....|.||
pombe   198 -TINRPLINDCLDMLNS-LPSENKKET----LYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEY 256

  Fly   248 MQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFI---------NDRLGFIYSECREMVSEERR 303
            :::..:..|.|..|::.:|.......|....|::.:         |...||.     .|:.....
pombe   257 LKKAEKRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFF-----SMIDSSNF 316

  Fly   304 QDLRNMYVVLKPIP---DNLKSELITTFLDHIKSEGLQTVSALKGE--------NIHIA--FVEN 355
            :.|:.:|.....:.   .:||..|......|.|.....|..||:|:        |..:|  :|:.
pombe   317 EGLQLVYESFSRVELGVKSLKKYLAKYVAHHGKLINETTSQALEGKMAVGRLSSNATMATLWVQK 381

  Fly   356 MLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKS--KT 418
            :|.:..:...:|:...:.|...|::|..|..:.::..      .|:.||::.:.|..|||.  |.
pombe   382 VLALWDRLNTIISTTMDADRSILNSLSDAFVTFVDGY------TRAPEYISLFIDDNLKKDARKA 440

  Fly   419 CEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTN 483
            .|..|:..|.|::|:|::|.:|||::|:|...|||||::.:|.|.|||.|||:||||..|..||.
pombe   441 IEGSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQ 505

  Fly   484 KLHRMFTDISVSVDL--NNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEK- 545
            ||..||.|:::|.:|  ..|.|:.|:.:...|.:|  :.:|.:..||:   .:.|..:...|.|
pombe   506 KLEGMFNDMNLSQELLQEYKHNSALQSAKPALDLN--VSILASTFWPI---DLSPHKIKCNFPKV 565

  Fly   546 ---SIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSC- 606
               .|..|.|:|....:||||.|...|...:::::...:.|.:.:.|....|:|||:......|
pombe   566 LLAQIDQFTDFYLSKHTGRKLLWYPSMGSADVRVNFKDRKYDLNVSTIASVILLLFQDLKENQCL 630

  Fly   607 --REIQNTLQLNDETFQKHMQPIIESK----LLNASSENLAGETRIELNLDYTNKRTKFKISSAL 665
              .||.....:.....::::|.:..:|    |.:.....:....:...|.::.:...:.|||:..
pombe   631 IFEEILEKTNIEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARIKISTVA 695

  Fly   666 QK--ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKK 728
            |.  |...|.:.|:..|||.||....|.|||:||.|||.:||.|:.||.......|.|:..|||:
pombe   696 QTRVEDDSERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKR 760

  Fly   729 CVESLIDKQYIERTANSGDEYSYMA 753
            .:|:||:::|::|.|::|..|.|:|
pombe   761 RIEALIEREYLQRQADNGRIYEYLA 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	160/655 (24%)
		CULLIN	436..575	CDD:214545	54/144 (38%)
		Cullin_Nedd8	680..745	CDD:214883	30/64 (47%)
cul3	NP_592949.1	COG5647	1..785	CDD:227934	209/803 (26%)
		CULLIN	458..601	CDD:214545	54/147 (37%)
		Cullin_Nedd8	717..777	CDD:287520	26/59 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820