DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul1

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_594259.1	Gene:	cul1 / 2542393	PomBaseID:	SPAC17G6.12	Length:	767	Species:	Schizosaccharomyces pombe

Alignment Length:	758	Identity:	221/758 - (29%)
Similarity:	395/758 - (52%)	Gaps:	60/758 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVERSVWNTSFSDVYT----LCV-AQPEPMADRLYGETKHFLEQ--------HVQEMLAKKVLIE 80
            :::..:..|.:.::||    .|. |......|....:|.:.|.:        :::|.||:   :.
pombe    37 RLDEGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLGEALYNNLVLYLEEYLAR---LR 98

  Fly    81 GECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIK-KQKITDTESFYGNLSSDAAEQ 144
            .||.......:.|..|...|..::...::::.|:.|||:..:| |.:.|:|..:
pombe    99 KECISQTNHEEQLAAYAKYWTRFTTSARFINHLFGYLNRYWVKLKNRFTETLVY----------- 152

  Fly   145 MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKT 209
             :|..|.|..|..::..::...|::::|......|....| |...|::....|.|.    .:.||
pombe   153 -DIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPT-DMKYVEVCVDSITSL----SFDKT 211

  Fly   210 G----SLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEV-IRILEYESRRAQKFLHVS 269
            .    :|..|:..||...:|.:..:|..|:::.|...|:::|:::. ||:.| |....:.:||.|
pombe   212 DMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAE-EEELVRLYLHES 275

  Fly   270 SLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHIKS 334
            :|..|.:..|:..|......::::...|:.:...:|:..||.::...|:.|: .|..||.:.:|.
pombe   276 TLKPLLEATEDVLIAQHEEVLHNDFARMLDQNCSEDIIRMYRLMSRTPNGLQ-PLRQTFEEFVKR 339

  Fly   335 EGLQTVSAL---KGENIHI---AFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRP 393
            .|...|:.:   .|....:   .::|.:|..:...:||:...|..|:.|..:||.|...::||..
pombe   340 SGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNV 404

  Fly   394 T-ERQPCRSAEYVAKYCDTLLKKS-KTCEA-EIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRL 455
            . :|...||.|.:|||.|::|:|| |..:. :::..|::.|.||:|:|||||:|.||::||||||
pombe   405 VCQRSSSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRL 469

  Fly   456 IHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDLGINLAIK 520
            ::..|.|.|||..|:::||:.||:|:|:||.|||.|||:|.::...| ..|..|... .|:.:..
pombe   470 VNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAF-WQLPQSRAG-NIDFSAL 532

  Fly   521 VLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKL---SHLKKS 582
            ||....||| |...:.|.:|:|.....:.|::||:...:||||:||.|:..||:|.   .....:
pombe   533 VLGTSFWPL-SPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARINPQTNVT 596

  Fly   583 YIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASSENLAGE--TR 645
            |:..:.||||.::||:...||.:..|:.....|:.:.....:...:::|:|.....:..|:  :.
pombe   597 YVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIFLKAKVLLLGDNDKLGDPNST 661

  Fly   646 IELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQE 710
            .::|.::..|:.:.:::..::.|..||...|..:::|||||.||:|||||||||:.|||..|::|
pombe   662 YKINENFRMKKIRVQLNLPIRSEQKQESLETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKE 726

  Fly   711 VLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .:...|..|||.::.||:|::.||:|:|:||...  |||.|:|
pombe   727 TIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQGR--DEYIYLA 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	174/630 (28%)
		CULLIN	436..575	CDD:214545	61/138 (44%)
		Cullin_Nedd8	680..745	CDD:214883	34/64 (53%)
cul1	NP_594259.1	COG5647	1..767	CDD:227934	220/756 (29%)
		CULLIN	450..589	CDD:214545	62/141 (44%)
		Cullin_Nedd8	696..763	CDD:214883	35/68 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820