Protein Alignment Cul2 and cul-3

DIOPT Version :9

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_503151.1
• Gene: cul-3 / 178547
• WormBaseID: WBGene00000838
• Length: 777
• Species: Caenorhabditis elegans
• Alignment Length: 823
• Identity: 203/823 - (24%)
• Similarity: 388/823 - (47%)
• Gaps: 146/823 - (17%)

  Fly    15 PRLRCIAESVITLT---------KVERSVWNTS-------FSDVYTLCVAQPEPMADRLYGETKH 63
            |.:..|.|..:|.|         :::|.  |.|       :.:.||:.:   ....:|||...|.
 Worm    17 PFMATIDEQYVTQTWELLKRAIQEIQRK--NNSGLSFEELYRNAYTMVL---HKHGERLYNGLKD 76

  Fly    64 FLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKIT 128
            .::.|:..:..:  :||.    .|.| ..|:....:|.:::..:..:..:.:|:::.::.:..
 Worm    77 VIQDHMASVRIR--IIES----MNSG-SFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNN-- 132

  Fly   129 DTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRH----------ILEGIAADRASNG 183
                          ..:.:..||||.:|        :|::|.          :||.|..||.||
 Worm   133 --------------HVLPVYNLGLDAYR--------TEILRQNGIGDRIRDALLELIKLDRKSN- 174

  Fly   184 TLDHHRVQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLL----HRCSV 244
            .::.|.::....::.|.       ...|..:|::.||.|:|:.:..||.|.....|    ..|.
 Worm   175 QINWHGIKNACDMLISL-------GIDSRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACF- 231

  Fly   245 SEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRL-GFIYSE---CREMVSEERRQD 305
              |:.:|...:..|:.||.::|...:..|:.:..::..:.:.: ..:|.:   .:.|:..::.:|
 Worm   232 --YLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEHIQTIVYMQNGGVKFMLEHKKIED 294

  Fly   306 LRNMYVVLKPIPDN-------LKSEL--ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHH 361
            |..::.:.|.|.|:       ||:.|  ::.:|:...|..::....||..   :.||..:|::..
 Worm   295 LTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDLLKNP---VNFVNELLQLKD 356

  Fly   362 KYQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTC--EAEID 424
            .:..|:...|.:|..|.:.......:.:|   :.||   |.|:||.|.|.:|:....|  :||:|
 Worm   357 YFSSLLTTAFADDRDFKNRFQHDFETFLN---SNRQ---SPEFVALYMDDMLRSGLKCVSDAEMD 415

  Fly   425 QKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMF 489
            .||.|.:.:|:|:::|||::|::.:.|||||:.::|.|.|.|:.::.:||..||.:||.||..||
 Worm   416 NKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMF 480

  Fly   490 TDISVSVDLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYY 554
            .|..:.:.|...|....:.....:.|:::::||.||.||  :.|..|..:|||...:.:||..||
 Worm   481 RDKELWLTLATSFRDWREAQPTKMSIDISLRVLTAGVWP--TVQCNPVVLPQELSVAYEMFTQYY 543

  Fly   555 HKLFSGRKLTWLHHMCHGELK--------------------------LSHLKKSY-IVTMQTYQM 592
            .:..:|||||....:.:.::|                          :...|..: |:.:.|:||
 Worm   544 TEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKERKPEHKILQVNTHQM 608

  Fly   593 AIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASSENL-----AGETRIEL---- 648
            .|:|.|...:.:||:::.:.|::.:...::::|    |..|..:|:.:     .|:..|::
 Worm   609 IILLQFNHHNRISCQQLMDELKIPERELKRNLQ----SLALGKASQRILVRKNKGKDAIDMSDEF 669

  Fly   649 --NLDYTNKRTKFKISSALQK-ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQE 710
              |.::.:|.|:.|:.....| |:..|:..|...|::||||.::|||||||||||.|.||.|:.|
 Worm   670 AVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKARKKLNHNNLVAE 734

  Fly   711 VLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            |....:..|.|:..:||:.:|:||:::|:.|..:....|.|:|
 Worm   735 VTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	151/655 (23%)
		CULLIN	436..575	CDD:214545	48/138 (35%)
		Cullin_Nedd8	680..745	CDD:214883	31/64 (48%)
cul-3	NP_503151.1	Cullin	32..674	CDD:279260	157/703 (22%)
		CULLIN	427..567	CDD:214545	49/141 (35%)
		Cullin_Nedd8	709..769	CDD:287520	28/59 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830