Protein Alignment Cul2 and cul-6

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_502412.1
• Gene: cul-6 / 178214
• WormBaseID: WBGene00000841
• Length: 729
• Species: Caenorhabditis elegans
• Alignment Length: 768
• Identity: 223/768 - (29%)
• Similarity: 371/768 - (48%)
• Gaps: 71/768 - (9%)

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVA---------QPEPMADRLYGETKHFLEQH 68
            ||..|:.....:.....:.:..:...:..||.:|..         .||..::.||.:.::::..:
 Worm     6 VWGTLQDGLNLLYRREHMSKKYYMMLYDAVYNICTTTTLANSNNNSPEFASEFLYKQLENYIRTY 70

  Fly    69 VQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESF 133
            |   :|.:..|.. ||    |.:||.:..|.|..:....:..:.::.|||:..:.| |:.|..
 Worm    71 V---IAIRDRISA-CS----GDELLGKCTIEWDNFKFSTRICNCIFQYLNRNFVSK-KVEDKN-- 124

  Fly   134 YGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIH 198
                    .|.:||.:|.||||:....:....:.:..|||.|..:|..:.....|    |:.|:.
 Worm   125 --------GEIVEIYKLALDIWKAEFFDNFKVKTIDAILELILLERCGSTINSTH----ISSVVE 177

  Fly   199 SFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQ 263
            ...|         |.:|:..||...|:|:..:|..|.  |..:.:|.|||..|...|..|..|::
 Worm   178 CLTE---------LDIYKVSFEPQFLDATKLFYKQEV--LNSKETVIEYMITVENRLFQEEYRSR 231

  Fly   264 KFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTF 328
            ::|..|:...|...||...|:|||.|::||...::...:.:.|..||.:.:.:...|  |.:..:
 Worm   232 RYLGPSTNDLLIDSCESILISDRLKFLHSEFERLLEARKDEHLTRMYSLCRRVTHGL--EDLRVY 294

  Fly   329 LD-HIKSEGLQTVSAL-KGENIHIA---FVENMLKVHHKYQELIADVFENDSLFLSALDKACASV 388
            |: .|..||.:|:..| |...:...   ::..:|:||..|..||...|:.::||:.:||||....
 Worm   295 LEKRILKEGHETLQRLAKDSGLKTTPKEYITKLLEVHEIYFNLINKAFDRNALFMQSLDKASKDF 359

  Fly   389 INRR------PTERQPCRSAEYVAKYCDTLLKKSKTCEAEIDQKLTNNITIFKYIEDKDVYQKFY 447
            |...      |.:.:..|||:|:|:|||.||||:...:.|  ..|...:|:.|||.:|||:|.:|
 Worm   360 IEANAVTMLAPEKHRSTRSADYLARYCDQLLKKNSKVQDE--TALDKALTVLKYISEKDVFQLYY 422

  Fly   448 SRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVD 512
            ....::|:|:..|.|.||||..|..|....|.|:|..|.:|..|..:|.||..:|    ||...:
 Worm   423 QNWFSERIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDAKISKDLTTEF----KDIKTE 483

  Fly   513 LGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLS 577
            ..|:..:.:...||||  |...|...:|:|....:|.|:.:|:...:||:|.|.:..|.||:...
 Worm   484 KSIDFNVILQTTGAWP--SLDQIKIILPRELSTILKEFDTFYNASHNGRRLNWAYSQCRGEVNSK 546

  Fly   578 HLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQK---HMQPIIESKLLNASSEN 639
            ..:|.|:..:...|:..:.||...||.:..:|...:::..::...   .:.|:|:..|:......
 Worm   547 AFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKSTSAIVGSLNPVIDPVLVVDKGNE 611

  Fly   640 LAG---ETRIELNLDYTNKRTKFKISSALQKET-PQEVEHTINSVDEDRKLFLQAAIVRIMKARK 700
            ..|   :..:.||..|.||:.:..:::|::|.| .:|.:...|:|:.|||..::|.||||||.||
 Worm   612 KDGYPPDAVVSLNTKYANKKVRVDLTTAIKKATADRETDAVQNTVESDRKYEIKACIVRIMKTRK 676

  Fly   701 VLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .|.|..||.|::|..|..||||:.|||.|:|.||::.||.|:.|..:.|.|:|
 Worm   677 SLTHTLLINEIISQLKSRFTPNVQMIKICIEILIEQLYIRRSENEHNVYEYLA 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	176/663 (27%)
		Cullin_Nedd8	683..745	CDD:463146	33/61 (54%)
cul-6	NP_502412.1	Cullin	7..627	CDD:459983	176/663 (27%)
		Cullin_Nedd8	659..721	CDD:463146	33/61 (54%)