Protein Alignment Cul2 and cul-1

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_499309.1
• Gene: cul-1 / 176466
• WormBaseID: WBGene00000836
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 783
• Identity: 243/783 - (31%)
• Similarity: 404/783 - (51%)
• Gaps: 60/783 - (7%)

  Fly    13 VWPRLRCIAESVITLTKVERSVWNTSFSDVY------TLCVAQPEPMADRLYGETK--------- 62
            ||.:|:...:.......:....:.|.::.||      ||..::.:....|....|.
 Worm    16 VWKKLQDGLDVAYRRENMAPKDYMTLYTSVYDYCTSITLSTSRRDGEDGRAESSTPARTAGADFV 80

  Fly    63 -HFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQK 126
             |.:.|.|:|.:...|:...|......|.|||:.|...|..:....|.:..::.|||:..|:::.
 Worm    81 GHEMYQRVEEYVKAYVIAVCEKGAELSGEDLLKYYTTEWENFRISSKVMDGIFAYLNRHWIRREL 145

  Fly   127 ITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQ 191
            ....|:.|           .:..|.|.:|:..:...|..:::..:||.|.::|  .|::.:.|
 Worm   146 DEGHENIY-----------MVYTLALVVWKRNLFNDLKDKVIDAMLELIRSER--TGSMINSR-- 195

  Fly   192 IINGVIHSFVEV------QDYKK---TGSLKLYQELFEGPMLEASGAYYTDE-ANKLLHRCSVSE 246
            .|:||:...||:      .|.||   |..|.:|:|.||...|||:..:||.| ||.|.:..:|::
 Worm   196 YISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTD 260

  Fly   247 YMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYV 311
            ||.:|...|..|..|.|.:|:.|:...|...||...|:::|.|:......::.::|..||..|:.
 Worm   261 YMIKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRMFK 325

  Fly   312 VLKPIPDNLKSELITTFLDHIKSEGLQTVS--ALKGENIHIAFVENMLKVHHKYQELIADVFEND 374
            :...:|:.| .||..:..:||..||.|.:.  |::.......:|:.:|:||.:||.|:...|:|:
 Worm   326 LCDRVPNGL-DELRKSLENHIAKEGHQALERVAMEAATDAKLYVKTLLEVHERYQSLVNRSFKNE 389

  Fly   375 SLFLSALDKACASVIN------RRPTERQPCRSAEYVAKYCDTLLKKSKTC--EAEIDQKLTNNI 431
            ..|:.:||||..|.||      |.|.:.|..:|||.:|:|||.||:||...  |||:::..|..:
 Worm   390 PGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAELEELQTKIM 454

  Fly   432 TIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSV 496
            .:||||:||||:.|||:::.:||||.|.|.|.:||...|.:||..||||:|.:|.:|..|..||.
 Worm   455 VVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQVSK 519

  Fly   497 DLNNKFNTHLKDSNVDLGINLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGR 561
            ||...|.....|......:...:.||.:|:||...|  .|..:||:..|:|::|..:|::.|:||
 Worm   520 DLTADFKEKKADMLGQKSVEFNVLVLSSGSWPTFPT--TPITLPQQLSKTIEIFGQFYNEKFNGR 582

  Fly   562 KLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQP 626
            :|||::....||:..:...|.|:.|..|.||..:|||...||.:..:|....::::::....:..
 Worm   583 RLTWVYSQSRGEITSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQIAAATKMDEKSAPAIVGS 647

  Fly   627 IIESKLLNASSE-----NLAGETRIELNLDYTNKRTKFKISS-ALQKETPQEVEHTINSVDEDRK 685
            :|::.:|.|.:|     .:.....:.||..|.||:.:..:|. .::::..::.|:...:|:||||
 Worm   648 LIKNLVLKADTELQKEDEVPMTATVSLNKAYMNKKVRVDLSKFTMKQDAVRDTENVQKNVEEDRK 712

  Fly   686 LFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYS 750
            ..:.|.||||||.||.::|..|:.||::.....|.|.:.|||:|:.|||:|:|:.||....|.|.
 Worm   713 SVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYE 777

  Fly   751 YMA 753
            |:|
 Worm   778 YLA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	202/678 (30%)
		Cullin_Nedd8	683..745	CDD:463146	29/61 (48%)
cul-1	NP_499309.1	Cullin	17..678	CDD:459983	202/678 (30%)
		Cullin_Nedd8	710..772	CDD:463146	29/61 (48%)