DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cul2 and CACUL1

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_722517.3	Gene:	CACUL1 / 143384	HGNCID:	23727	Length:	369	Species:	Homo sapiens

Alignment Length:	119	Identity:	28/119 - (23%)
Similarity:	55/119 - (46%)	Gaps:	27/119 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WPRLRCIAESVITLTKVERSVWNTSFSDVYTL---CVAQPEPMADRLYGE-----TKHFLEQHVQ 70
            ||:|....:.:  ||:........|:..:|:.   ||.|..  ::::|.:     |.| ||:..:
Human   137 WPKLDGAIDQL--LTQSPGDYIPISYEQIYSCVYKCVCQQH--SEQMYSDLIKKITNH-LERVSK 196

  Fly    71 EMLAKKVLIEGECSHSNGGPDL-LQRYYITWMEYSQGIKYLHQLYIYLNQQHIK 123
            |:.|..             ||| ::|:.|...:|...::.:..|:||:|:.:|:
Human   197 ELQASP-------------PDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIE 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	22/94 (23%)
		CULLIN	436..575	CDD:214545
		Cullin_Nedd8	680..745	CDD:214883
CACUL1	NP_722517.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Cullin	138..>256	CDD:279260	27/118 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..369
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900