Protein Alignment Cul2 and Cul1

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: XP_061518789.1
• Gene: Cul1 / 1277942
• VectorBaseID: AGAMI1_005719
• Length: 778
• Species: Anopheles gambiae
• Alignment Length: 804
• Identity: 282/804 - (35%)
• Similarity: 432/804 - (53%)
• Gaps: 94/804 - (11%)

  Fly     6 KIVEFVDVWPRLRCIAESVITLTKVERSV----WNTSFSDVYTLCVA---QP------------- 50
            |.:...::|..|....:.|.   |.|.|:    :...::.||..|.:   ||
Mosquito    13 KNINLEEIWTDLEAGIKQVY---KRELSLGIARYMELYTHVYNYCTSVHQQPNSRTGSSKISKKG 74

  Fly    51 --------EPMADRLYGETKHFLEQHVQEMLAKKVLIEGECSHSNG----GPDLLQRYYITWMEY 103
                    :.:...||...|.|||.::..:            |.||    ..::|..|...|.||
Mosquito    75 ISAPPGGAQLVGQELYKRLKEFLENYLVRL------------HQNGIDLMDEEVLSFYTKRWEEY 127

  Fly   104 SQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEYLSSELV 168
            ....|.|:.:..|||:..:|::.....:..|           ||.:|.|..||..:.::|:.::.
Mosquito   128 QFSSKVLNGVCAYLNRHWVKRECEEGRKDVY-----------EIYQLALVTWRGNLFKHLNKQVT 181

  Fly   169 RHILEGIAADRASNGTLDHHRVQIINGVIHSFVEV-----QDYKKTGSLKLYQELFEGPMLEASG 228
            ..:|:.|  :|..||...:.|  :::|||:.:||:     ..:.|..:|.:|:|.||...||.:.
Mosquito   182 NAVLKLI--ERERNGETINSR--LVSGVINCYVELGLNEDDPHAKGQNLSVYKESFENIFLEDTE 242

  Fly   229 AYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSE 293
            .:||.|:.:.|....|:|||:.|...|..|.:|.|.:||.|:|.:|.::||...|:..|....:|
Mosquito   243 RFYTRESAEFLRENPVTEYMKRVELRLNEEQKRVQVYLHESTLDRLAEKCERVLIHIHLDQFRTE 307

  Fly   294 CREMVSEERRQDLRNMYVVLKPIPDNL--KSELITTFLDHIKSEGLQTV-----SALKGENIHIA 351
            .:.:::.::.|||..||.::..|...|  ..|::.|   ||.::||..:     ||:....|
Mosquito   308 FQNLLNSDKNQDLGRMYSLVARIKAGLYELKEILET---HIHNQGLAAIEKCGDSAVNDPKI--- 366

  Fly   352 FVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRP-TE--RQPCRSAEYVAKYCDTLL 413
            :|:.:|:||.||..|:...|.|||.|::||||||...||... ||  |...:|.|.:|||||.||
Mosquito   367 YVQTILEVHKKYNALVLTAFNNDSGFVAALDKACGKFINTNAVTELSRSASKSPELLAKYCDLLL 431

  Fly   414 KKSKTC--EAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQA 476
            |||...  |||::..|...:.:|||||||||:|||||::|||||....|.|.|||..||::||||
Mosquito   432 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYSKMLAKRLCQHMSASDDAEASMISKLKQA 496

  Fly   477 CGYEFTNKLHRMFTDISVSVDLNNKFNTH---LKD--SNVDLGINLAIKVLQAGAWPLGSTQVIP 536
            ||:|:|:||.|||.||.||.|||:::..|   |:|  |.....|:.:|.||.:|:||.|  |...
Mosquito   497 CGFEYTSKLQRMFQDIGVSKDLNDQYRKHHEKLRDTRSTTQNEIDFSILVLSSGSWPFG--QGFT 559

  Fly   537 FAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETC 601
            |::|.|.|:|:..|.::|.|..|||||.||::||.|||..:..:..|.:...|:|||::|.|...
Mosquito   560 FSLPFELEQSVHRFNNFYAKQHSGRKLNWLYNMCRGELITNCFRMRYTLQASTFQMAVLLQFNEE 624

  Fly   602 DSLSCREIQNTLQLNDETFQKHMQPIIESKLLNA--SSENLAGETRIELNLDYTNKRTKFKISSA 664
            .:.|.:::.....:|:|...:.:..::::||||.  ....|..::.||||.|:.|::.:..|:..
Mosquito   625 TAWSIKQLGENTGINNENLIQVLPILLKTKLLNCYEGEGKLHPDSTIELNKDFKNRKLRININFP 689

  Fly   665 LQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKC 729
            |:.|...|.|.|..:::||||:.:|||||||||.||:|.|..|:.|||:.....|.|.|.:||||
Mosquito   690 LKSELKVEQEATHKNIEEDRKILIQAAIVRIMKMRKMLNHTQLVNEVLNQLSTRFKPKIQVIKKC 754

  Fly   730 VESLIDKQYIERTANSGDEYSYMA 753
            ::.||:|:|:||.....|.|||:|
Mosquito   755 IDILIEKEYLERQEGQKDTYSYLA 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	234/693 (34%)
		Cullin_Nedd8	683..745	CDD:463146	33/61 (54%)
Cul1	XP_061518789.1	None