Protein Alignment Cul2 and Cul3

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: XP_061516687.1
• Gene: Cul3 / 1277848
• VectorBaseID: AGAMI1_007458
• Length: 785
• Species: Anopheles gambiae
• Alignment Length: 831
• Identity: 213/831 - (25%)
• Similarity: 380/831 - (45%)
• Gaps: 149/831 - (17%)

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDV----YTLCVAQPEPMADRLYGET 61
            |::..|.||  .:|..|:   .::..:.|...|  ..||.::    ||:.:   ....:|||...
Mosquito    26 MTMDEKYVE--SIWSLLK---NAIQEIQKKNNS--GLSFEELYRNAYTMVL---HKHGERLYSGL 80

  Fly    62 KHFLEQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQK 126
            |..:..|::..:.::||....|       :.||.....|.::...:..:..:.:|:::.::::
Mosquito    81 KEVVTHHLESKVREEVLRSFNC-------NFLQTLNQCWNDHQTSMVMIRDILMYMDRVYVQQ-- 136

  Fly   127 ITDTESFYGNLSSDAAEQMEIGELGLDIWRLYMIEY--LSSELVRHILEGIAADRASNGTLDHHR 189
             .|.::.|              .|||:|:|..::.|  :...:...:|..:..:|... .:||..
Mosquito   137 -NDVDNVY--------------NLGLNIFRDQVVRYPRIRDHMRETLLNMVMCERKGE-AIDHIA 185

  Fly   190 VQ------IINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYM 248
            ::      ::.|:...:|             |:|.||.|.|..|.|:|..|:.|.|...|.|.|:
Mosquito   186 IKNACQMLMVLGINQRWV-------------YEEDFERPFLTQSAAFYKLESQKFLAENSASVYI 237

  Fly   249 QEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRL---------GFIYSECREMVSEERRQ 304
            :.|...:..|:.||:.:|..|:..::.:..|::.|...:         |.:|     |:...:.:
Mosquito   238 RRVEARITEEAERAKLYLDESTESRIVEVVEDELIKKHMRTIVEMENSGVVY-----MLQNTKTE 297

  Fly   305 DLRNMYVV-------LKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHK 362
            ||..|:.:       ||.|.|.:...|.:...|.:|.|.       .|....|.||:|:|.:..:
Mosquito   298 DLACMHKLFSRVSGGLKTIADCVSQNLRSLGRDLVKEEE-------NGSTNPITFVQNLLDLKDR 355

  Fly   363 YQELIADVFENDSLFLSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTC----EAEI 423
            ....:...|.||..|.:.:.......:|..      .:|.||::.:.|..|||.  |    |.||
Mosquito   356 SDHFLYHSFNNDKTFKNMISSDFEHFLNLN------SKSPEYLSLFIDDKLKKG--CKGMSEQEI 412

  Fly   424 DQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRM 488
            :..|...:.:|:|:::|||::::|...|||||:..:|.|.|:|:.||::||..||.:||:||..|
Mosquito   413 ETILDKTMVLFRYLQEKDVFERYYKAHLAKRLLLNKSVSDDSEKNMISKLKTECGCQFTSKLEGM 477

  Fly   489 FTDISVSVDLNNKFNTHLKDSNVDL-GINLAIKVLQAGAWPLGSTQVIPFA-VPQEFEKSIKMFE 551
            |.|:|||..:..:|..|:.:.|..| |:.|.:::|..|.||..|  |.|.. :|....|:.:.|:
Mosquito   478 FKDMSVSNTVMEEFKNHINNDNSALEGVELTVRILTTGFWPTQS--VTPNCNIPAAPRKAFETFK 540

  Fly   552 DYYHKLFSGRKLT--------WLHHMCHGELKLSHLK---------------------------- 580
            .:|....|||:||        :::...:| :|....|
Mosquito   541 RFYLAKHSGRQLTLQPQLGTVYMNAEFYG-VKAEKEKTEGNCSSTAPSAGSSSAPTGGAASLDAP 604

  Fly   581 KSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPII----ESKLL---NASSE 638
            |.:::.:.||||.:::||...:.::..:||....:..:...:.:|.:.    :.:||   ..:|:
Mosquito   605 KRHVLQLSTYQMCVLMLFNNRERMTYEDIQQETDIPSKDLIRALQSLSMGKQQQRLLVRTPKTSK 669

  Fly   639 NLAGETRIELNLDYTNKRTKFKISSALQK-ETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVL 702
            .:.......:|..:.:|..|.||.:...| |:..|.:.|.:.||||||..::|||||||||||.:
Mosquito   670 EIVSTDEFYVNDAFVSKFHKVKIQTVAAKGESEPERKETRSKVDEDRKHEIEAAIVRIMKARKRM 734

  Fly   703 KHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .||.|:.:|.|..|..|.|:..:|||.:|.||:::|:.||......|.|:|
Mosquito   735 PHNLLVSDVTSQLKSRFLPSPVIIKKRIEGLIEREYLARTPEDRKIYVYLA 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	164/714 (23%)
		Cullin_Nedd8	683..745	CDD:463146	31/61 (51%)
Cul3	XP_061516687.1	None