Protein Alignment Cul2 and Cul2

DIOPT Version :10

• Sequence 1: NP_610117.1
• Gene: Cul2 / 35420
• FlyBaseID: FBgn0032956
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: XP_313365.5
• Gene: Cul2 / 1274269
• VectorBaseID: AGAMI1_002671
• Length: 766
• Species: Anopheles gambiae
• Alignment Length: 767
• Identity: 477/767 - (62%)
• Similarity: 598/767 - (77%)
• Gaps: 15/767 - (1%)

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65
            |||||:.:.|.:||..||...:.||||..::|.|||..|.|||.:|||.|||:|||||.|||.||
Mosquito     1 MSLKPRRIAFDEVWKELRETVQQVITLQDIKRDVWNNRFVDVYEICVAHPEPLADRLYLETKTFL 65

  Fly    66 EQHVQEMLAKKVLI------EGECSHSNGGPD-----LLQRYYITWMEYSQGIKYLHQLYIYLNQ 119
            |.|||.:|.::|||      ..|.|...|...     ||:|||..|||||.|.:||:.||:||||
Mosquito    66 ENHVQTLLEERVLIGDSQNASNEQSAGTGSSSASPYLLLERYYDVWMEYSSGSQYLNHLYLYLNQ 130

  Fly   120 QHIKKQKITDTESFYG-NLSSDAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNG 183
            |||||||:.:.|:.|| :...|..|:||||||.|:||..|||:.|.:|||..||.||.|:|.:|.
Mosquito   131 QHIKKQKLNEAEAVYGCSNHGDNQEKMEIGELTLEIWNQYMIQRLGNELVDQILSGINAERVNNS 195

  Fly   184 TLDHHR-VQIINGVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEY 247
            :..|:: .::|.|||.|||.||:.::.|||||||||||..|||.||..:...|::||..||||:|
Mosquito   196 SGQHNKSTEVIRGVIQSFVAVQEDRRKGSLKLYQELFETRMLEESGQNFRIVASELLQVCSVSQY 260

  Fly   248 MQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVV 312
            |:.:|:..|.|.:.|:.:||.||||||||.|||:.:...:.|:||||:|||:.|:..||||:|::
Mosquito   261 MERIIKKFEEEEKLAKIYLHESSLPKLRKVCEEEMVTKHMNFLYSECKEMVATEKSTDLRNLYIL 325

  Fly   313 LKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLF 377
            |||:.|.|| .||..||:|||.:|.:|:|.:||:::||.||||||.||.||:|||...|::|.||
Mosquito   326 LKPVTDGLK-RLIEVFLEHIKEQGKKTISCMKGDSVHIQFVENMLDVHRKYEELIHTTFKSDPLF 389

  Fly   378 LSALDKACASVINRRPTERQPCRSAEYVAKYCDTLLKKSKTCEAEIDQKLTNNITIFKYIEDKDV 442
            |.|||||||.:||.:.:..|.|||||.||||||:|||||||.|.|||||||.:|.||||||||||
Mosquito   390 LGALDKACARIINEKHSNNQVCRSAELVAKYCDSLLKKSKTTEGEIDQKLTRSIIIFKYIEDKDV 454

  Fly   443 YQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK 507
            |||||||:|||||||||||||||||.|||:|||||||||||||||||||||||.|||.||:.:|.
Mosquito   455 YQKFYSRMLAKRLIHEQSQSMDAEELMINKLKQACGYEFTNKLHRMFTDISVSTDLNAKFSKYLN 519

  Fly   508 DSNVDLGINLAIKVLQAGAWPLGSTQVI-PFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCH 571
            |:..:.|||.::|||||||||||.|||: .||:||||||||::||::||..|||||||||||:||
Mosquito   520 DNKHETGINFSVKVLQAGAWPLGPTQVVASFAIPQEFEKSIRLFEEFYHINFSGRKLTWLHHLCH 584

  Fly   572 GELKLSHLKKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNAS 636
            ||:|||..|::||||||||||||:|:||..|..:|:|:|.:|||..|.||:|:|.::|:|:|..:
Mosquito   585 GEMKLSFEKRNYIVTMQTYQMAILLMFENTDKYTCKELQTSLQLQQEIFQRHLQSLVEAKILLLN 649

  Fly   637 SENLAGETRIELNLDYTNKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKV 701
            .|.:..:|.:.:|::|:||||||||::.||||||||||||:|:||||||::||||||||||:|||
Mosquito   650 EEKMNDDTEVSINVNYSNKRTKFKITTNLQKETPQEVEHTMNAVDEDRKMYLQAAIVRIMKSRKV 714

  Fly   702 LKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            |:||.||||:||.|||||.||::|||||:||||||||||||.||||||||:|
Mosquito   715 LRHNTLIQEILSQSKVSFAPNVSMIKKCIESLIDKQYIERTPNSGDEYSYVA 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	14..652	CDD:459983	387/651 (59%)
		Cullin_Nedd8	683..745	CDD:463146	49/61 (80%)
Cul2	XP_313365.5	None