DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul2

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_002935209.2	Gene:	cul2 / 100492608	XenbaseID:	XB-GENE-960931	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	383/782 - (48%)
Similarity:	535/782 - (68%)	Gaps:	45/782 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKPKIVEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCVAQPEPMADRLYGETKHFL 65
            |||||::|:|.:.|.:|....::|:.|..|||:.||..|||:|.||||.|||:.:|||.|||.||
Frog     1 MSLKPRVVDFDETWNKLLTTIKAVVMLDYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFL 65

  Fly    66 EQHVQEMLAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDT 130
            |.|||: |..:||...|        .:|..||..|.|||:|..|:..||.|||.|:|||.|:|:.
Frog    66 ENHVQQ-LHTRVLDSAE--------QVLVMYYRYWEEYSRGADYMDCLYRYLNTQYIKKNKLTEA 121

  Fly   131 ESFYGNLSSDAAEQ-MEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIIN 194
            :..||....|..|. ||||||.||:||..|||.|...|:|.:|:.|..||..    :....::|:
Frog   122 DLQYGYGGVDMNEPLMEIGELALDLWRKLMIEPLQDTLLRMLLKEIKRDRCG----EDPNQKVIH 182

  Fly   195 GVIHSFVEVQDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYES 259
            |||:|||.|:.|||...||.|||:||.|.|..:|.||..||:.||...:.|:||::::..|:.|.
Frog   183 GVINSFVHVEQYKKKFPLKFYQEIFELPFLAETGEYYKQEASNLLQESNCSQYMEKILGRLKDEE 247

  Fly   260 RRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSEL 324
            .|.:|:||.||..|:..||:::.:.|.|.|:::||..::.:|||.|:.|||.:|:.:.:.| ..:
Frog   248 IRCRKYLHPSSYNKVIHECQQRMVADHLQFLHAECHNIIRQERRSDMANMYTLLRAVSNGL-PHM 311

  Fly   325 ITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVI 389
            |....:||..|||:.:|.|..||:...|||::|:||.|:.:|:..|...|..|:||||||...|:
Frog   312 IQELQNHIHDEGLRAISNLSQENMPTQFVESVLEVHSKFVQLVNSVLNGDQHFMSALDKALTCVV 376

  Fly   390 N-RRPTERQPCRSAEYVAKYCDTLLKKSK--TCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLL 451
            | |.|  :..|::.|.:|||||.:||||.  ..|.|::.|||:.||:||||:||||:||||:|:|
Frog   377 NYREP--KSVCKAPELLAKYCDNMLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARML 439

  Fly   452 AKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK--DSNVDLG 514
            ||||||..|.|||:||.|||:||||||||||:|||||:||:|||.|||||||..:|  |:.:|||
Frog   440 AKRLIHGLSMSMDSEETMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLG 504

  Fly   515 INLAIKVLQAGAWPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL 579
            |:..|.|||||||||.......||:|||.|||::|||.:|::.||||||||||::|.||:|:::|
Frog   505 ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYLCTGEVKMNYL 569

  Fly   580 KKSYIVTMQTYQMAIILLFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASS--ENLAG 642
            .|.|:..:.|||||::|.|...:.::.:|:|::.|:|::...|.::.:::.|::|..|  |::.|
Frog   570 CKPYVAMVTTYQMAVLLAFNNSEIVTYKELQDSTQMNEKELTKTIKSLLDVKMINHDSDKEDIDG 634

  Fly   643 ETRIELNLDYTNKRTKFKISSALQKETPQ---------------------EVEHTINSVDEDRKL 686
            |:...||:::::|||||||::.:||:|||                     |||.|.::||||||:
Frog   635 ESTFSLNMNFSSKRTKFKITTPMQKDTPQGAQPTCAEEAMLWRGERRFSLEVEQTRSAVDEDRKM 699

  Fly   687 FLQAAIVRIMKARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSY 751
            :|||||||||||||:|:||||||||:|.|:..|.|:|:|||||:|.|||||||||:..|.|||||
Frog   700 YLQAAIVRIMKARKILRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSY 764

  Fly   752 MA 753
            :|
Frog   765 VA 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	291/607 (48%)
		CULLIN	436..575	CDD:214545	95/140 (68%)
		Cullin_Nedd8	680..745	CDD:214883	48/64 (75%)
cul2	XP_002935209.2	Cullin	14..644	CDD:395716	305/645 (47%)
cul2	XP_002935209.2	Cullin_Nedd8	696..756	CDD:402267	45/59 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	582	1.000	Domainoid score	I211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2662
Inparanoid	1	1.050	730	1.000	Inparanoid score	I610
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0007132
OrthoInspector	1	1.000	-	-		oto104956
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5314
SonicParanoid	1	1.000	-	-		X5228
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190