DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul2 and cul5b

DIOPT Version :9

Sequence 1:	NP_610117.1	Gene:	Cul2 / 35420	FlyBaseID:	FBgn0032956	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_009293667.1	Gene:	cul5b / 100006147	ZFINID:	ZDB-GENE-091113-45	Length:	807	Species:	Danio rerio

Alignment Length:	831	Identity:	219/831 - (26%)
Similarity:	375/831 - (45%)	Gaps:	121/831 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VEFVDVWPRLRCIAESVITLTKVERSVWNTSFSDVYTLCV---AQPEPMADRLYGETKHFLEQHV 69
            ::|.|.|..:|.|...::....|.:..|...||||:.:|:   ..|..:...|..:...|::| .
Zfish    13 LQFEDKWDLMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILDFIKQ-A 76

  Fly    70 QEM--------LAKKVLIEGECSHSNGGPDLLQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQK 126
            |.|        |..:||     ||.: ...||:.|.:.|.::......|.:.:        .|.:
Zfish    77 QAMENIIVFLSLCVRVL-----SHQD-DTALLKAYIVEWRKFFTQCDILPKPF--------SKLE 127

  Fly   127 ITDTESFYGNLSSDAAEQME---IGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHH 188
            ||    ..||..|:....:|   :.:|.||.|...:...:.|.|....::.:.|:|... ..|.
Zfish   128 IT----LLGNQGSNKKSNVEDSIVRKLMLDTWNESIFCNIKSRLQDSAMKLVHAERLGE-AFDS- 186

  Fly   189 RVQIINGVIHSFVEV---QDYKKTGSLKLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQE 250
              |::.||..|:|.:   .|.|    |::|:|.||...|:::..:|..:|...|.:..|..||:.
Zfish   187 --QLVIGVRESYVNLCSNTDDK----LQIYRENFEKSYLDSTERFYKTQAPSYLQQNGVQNYMKY 245

  Fly   251 VIRILEYESRRAQKFLHV----SSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQ------- 304
            ....|..|.:||.::|..    :|:..|.:.|....:......|.:||..|:.....:
Zfish   246 ADGKLREEEKRALRYLETRRECNSVQALMECCVNALVTSFKETILTECPGMIKRNETESEYGRSS 310

  Fly   305 --------DLRNMYVVLKPIPDNLKSELITTFLDHIKSEGLQTVSALKGENIHI---AFVENMLK 358
                    :|..|:.::..:|..:: .::....|||.|.||..:.| ..|.|..   .:||.:|.
Zfish   311 GTKGSASSELHLMFSLMDKVPSGIE-PMLKDLEDHIMSAGLADMVA-SAETITTDSEKYVEQLLT 373

  Fly   359 VHHKYQELIADVFENDSLFLSALDKACASVIN-------------------RRPTERQPCRSAEY 404
            :.:::.:|:.:.|::|..||::.|||..:|:|                   .:|..:.|    |.
Zfish   374 LFNRFSKLVKEAFQDDPRFLTSRDKAYKAVVNDATIFKLELPLKQKGVSLKTQPESKCP----EL 434

  Fly   405 VAKYCDTLLKKS----KTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDA 465
            :|.|||.||:|:    |....||:.||...:.:.||:::|||:.:::...|.:|||.:.|...:.
Zfish   435 LANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEI 499

  Fly   466 EEGMINRLKQ-ACGYEFTNKLHRMFTDISVSVDLNNKFNTHLKDSNVDL---GINLAIKVLQAGA 526
            ||.|:..|:: ....::.|||.|||.||.||.|||..|....|.:.:.|   .:|  ||:|.|||
Zfish   500 EENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHNKLALPADSVN--IKILNAGA 562

  Fly   527 WPLGSTQVIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQ 591
            |...|.:|. .::|.|.|..|...||:|.|..|||||.|.|.|.:|.:...:....|.:.:.|:|
Zfish   563 WSRSSEKVF-VSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQ 626

  Fly   592 MAIILLF--ETCDSLSCREIQNTLQLNDE----------TFQKHMQPIIESKLLNASSENLAGET 644
            :|::..:  ...:.:|...::...:|.|.          .|.|..:.::..:.:..|.::.|..|
Zfish   627 LAVLFAWNQRPRERISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLSYEPVVGSPKDFAEGT 691

  Fly   645 RIELNLDYT-------NKRTKFKISSALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMKARKVL 702
            ...:|.:::       .||.|..:...||..|.:..|.....:.:.|.|..|.||::|||.||.:
Zfish   692 VFSINQEFSLIKNSKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKRI 756

  Fly   703 KHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 753
            .:..|..|::.:.|..|.|...|||:.:|.||:.:||:|.....:.:.|||
Zfish   757 SNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIKRDETDINTFIYMA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul2	NP_610117.1	Cullin	39..639	CDD:279260	175/677 (26%)
		CULLIN	436..575	CDD:214545	56/142 (39%)
		Cullin_Nedd8	680..745	CDD:214883	24/64 (38%)
cul5b	XP_009293667.1	Cullin	20..698	CDD:279260	182/713 (26%)
		CULLIN	470..613	CDD:214545	56/145 (39%)
		Cullin_Nedd8	740..799	CDD:287520	23/58 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820