DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and Phlpp1

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:732 Identity:125/732 - (17%)
Similarity:239/732 - (32%) Gaps:248/732 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 LPLQLIFLGLSIGC---ITYFICLS-----LPVGYSHWDSLLSNQLA-ANAVLIATAALIGLLYY 232
            :|..|.::.:|..|   :..::|.|     |.:|:        ||:. ..|.|...::|..||  
Mouse   848 VPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGH--------NQICELPARLFCNSSLRKLL-- 902

  Fly   233 FMGEAKQKR--AFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMRE-------------- 281
             .|..:..|  ..|| :.|:||..|...|..|        ||.::.:|...              
Mouse   903 -AGHNRLARLPERLE-RTSVEVLDVQHNQITE--------LPPNLLMKADSLRFLNASANKLETL 957

  Fly   282 ---DLGSSSSEAFKKIYMSR-------------HENVSILYADIVGFTAISSTYSAQDLVKMLNE 330
               .|...:|...:::|::.             |..:.||:   :.:..:.| :.|..:.|:  |
Mouse   958 PPATLSEETSSILQELYLTNNCLTDKCVPLLTGHPRLKILH---MAYNRLQS-FPASKMAKL--E 1016

  Fly   331 LFARFDRLAEKYQQLRIKILGDC---------YYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQ 386
            .....|....|.:.:...|: :|         ..||...|:......|.||.:..:.:..|...:
Mouse  1017 ELEEIDISGNKLKAIPTTIM-NCRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPE 1080

  Fly   387 QKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKM---------------------- 429
               |.|..::.        ..:.|..:...|  .|.:||.|.:                      
Mouse  1081 ---NLPPKLQE--------LDLTGNPRLALD--HKSLELLNNIRCFKIDQPSAGDASGAPAVWSH 1132

  Fly   430 ---ESSGKAGRVHIS-----------DKTLAFLNGEFEVEAAF-------GEKREELLRIAGLKT 473
               |:||...::.::           :......:|:..||..:       ....|||.:....:.
Mouse  1133 GYTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEE 1197

  Fly   474 YFITK--VVKAFASPCAKKINETQAEIAH--PNP---NGSTTDIVSDEDDNDATLDDEELLAQNS 531
            |.:..  |::.......:|:... |.:.|  |:|   .||.|...::.......|          
Mouse  1198 YMVNTFIVMQRKLGTAGQKLGGA-AVLCHIKPDPVDLGGSFTLTSANVGKCQTVL---------- 1251

  Fly   532 VSNGHQIGIA---VTADEEEQVKLENFKQRLKDELVTRDGHEN-LTKDTNIF-LRFKNPQL---E 588
            ..||..:.::   :.:.|||:.:::..|     .::|.||..| :|:.|.|. ..|.:|.:   .
Mouse  1252 CRNGKPLSLSRSYIMSCEEERKRIKQHK-----AIITEDGKVNGVTESTRILGYTFLHPSVVPRP 1311

  Fly   589 QLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGM 653
            .:.:|...|.....:|.:      ..|:..|.:..:.....|:...|.  |...:.:||:|:.  
Mouse  1312 HVQSVLLTPQDEFFILGS------KGLWDSLSIDEAVEAVRNVPDALA--AAKKLCTLAQSYG-- 1366

  Fly   654 LPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASL--- 715
                       .:|     .::|:::.|::                ||......|.:...|:   
Mouse  1367 -----------CHD-----SISAVVVQLSV----------------TEDSFCCCELSAGGSMPPP 1399

  Fly   716 -----ESDINLVVE--------------GMV------------------TAEHLLPASFVEQMRD 743
                 ...:|:|::              ||.                  ||....|:..:.:...
Mouse  1400 SPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPSGVLNESSP 1464

  Fly   744 AVPTER--VLYPSYLSN 758
            |.|.|:  :|:|..|||
Mouse  1465 AYPNEQRCMLHPVCLSN 1481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 29/135 (21%)
CYCc 256..453 CDD:214485 38/271 (14%)
Guanylate_cyc 294..476 CDD:278633 37/246 (15%)
CYCc 860..1071 CDD:214485
Guanylate_cyc 892..1092 CDD:278633
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 9/44 (20%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566
LRR 3 648..669
LRR 4 671..692
leucine-rich repeat 672..694 CDD:275380
LRR 5 694..715
leucine-rich repeat 695..717 CDD:275380
LRR 6 717..739
leucine-rich repeat 718..740 CDD:275380
LRR 7 740..760
leucine-rich repeat 741..764 CDD:275380
LRR 8 764..785
LRR_RI 768..1030 CDD:238064 40/207 (19%)
leucine-rich repeat 768..788 CDD:275380
LRR 9 788..809
leucine-rich repeat 789..809 CDD:275380
leucine-rich repeat 810..851 CDD:275380 1/2 (50%)
LRR 10 829..850 0/1 (0%)
LRR 11 851..872 4/20 (20%)
leucine-rich repeat 852..874 CDD:275380 5/21 (24%)
LRR 12 874..895 6/28 (21%)
leucine-rich repeat 875..897 CDD:275380 6/29 (21%)
LRR_8 896..954 CDD:290566 16/69 (23%)
LRR 13 897..918 7/24 (29%)
leucine-rich repeat 898..919 CDD:275380 7/24 (29%)
LRR 14 919..940 8/28 (29%)
leucine-rich repeat 920..943 CDD:275380 8/30 (27%)
LRR 15 943..964 1/20 (5%)
leucine-rich repeat 944..967 CDD:275380 1/22 (5%)
LRR 16 969..989 1/19 (5%)
LRR_8 970..1028 CDD:290566 9/63 (14%)
leucine-rich repeat 970..993 CDD:275380 2/22 (9%)
LRR 17 993..1014 4/24 (17%)
leucine-rich repeat 994..1017 CDD:275380 5/28 (18%)
LRR 18 1017..1038 3/21 (14%)
LRR 19 1040..1061 3/20 (15%)
LRR 20 1062..1083 5/23 (22%)
leucine-rich repeat 1063..1085 CDD:275380 6/24 (25%)
LRR 21 1085..1106 3/30 (10%)
PP2Cc 1124..1376 CDD:214625 48/293 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465 5/50 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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