Protein Alignment Ac3 and Adcy7

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_445848.1
• Gene: Adcy7 / 84420
• RGDID: 619966
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1202
• Identity: 385/1202 - (32%)
• Similarity: 557/1202 - (46%)
• Gaps: 293/1202 - (24%)

  Fly    61 YSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALR 125
            |.:.:...|.|    .|||:..:.:   ..|..|..::  .:|:|.....||:.|....:.  ||
  Rat     7 YFLNEGDEGPK----QAALYEKYRL---TSQHGPLLLL--LLLVAVATCIALVSIVFSHED--LR 60

  Fly   126 RFHQILLIIVPRALWLLSILHFTVYV--ILQPSFSPRDLLGWAIL-------------------- 168
            | ||.:|......|.|...|:..|||  :.|.......||.||.|
  Rat    61 R-HQAVLGTAFFMLTLFVALYVLVYVECLAQRWLRVLALLTWACLMILGSVLMWDSLENEAYAWE 124

  Fly   169 -------LNFLVYVTLPLQ---LIFLGL--SIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLI 221
                   :.|:|||.|||.   .|.:|:  :|..:..|..::.....|...:.|..||.||||::
  Rat   125 QVPFFLFIVFVVYVLLPLSTRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVIL 189

  Fly   222 ATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMR------ 280
            ......|..:....:...:..|:...|.::::..:..:..:||.|||||||.|:::.|:
  Rat   190 LGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIER 254

  Fly   281 ----EDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEK 341
                .|...:....|..:|:.||:|||||||||||||.::|..|.::||.:|||||.:||::|:.
  Rat   255 LKEGGDRHYTPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKA 319

  Fly   342 YQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLA 406
            .:.:|||||||||||:||.|...|.||..||.|||.:.:|||.|::.....:.||||||:|.||.
  Rat   320 NECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLC 384

  Fly   407 GILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGL 471
            |::|.|:||:||:|.||.|||:||::|..|||||::.||..|:..:|||...||:|:..|:...:
  Rat   385 GVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNI 449

  Fly   472 KTYF--------------------------------ITKVVKAF--ASPCA---KKINETQAEIA 499
            :||.                                :|:.::::  |.|.|   .:.:.:.:||.
  Rat   450 RTYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSEIP 514

  Fly   500 HPN--------------PNGSTTDIVSDEDDNDATLDDEELLAQNSVSNG----------HQIGI 540
            .||              |:.|.:.....|||    .|||.|.|...:|:.          |..|
  Rat   515 IPNGRRQKAIPLRRHRAPDRSASPKGRLEDD----CDDEMLSAIEGLSSTRPCCSKSDDFHTFG- 574

  Fly   541 AVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLA 605
                                                .|||.....:..:|..:.|..|..  ..|
  Rat   575 ------------------------------------PIFLEKGFEREYRLVPIPRARYDF--ACA 601

  Fly   606 ALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITF 670
            :|:..|| :|...||:||                   :.:|..||.
  Rat   602 SLVFVCI-LLVHLLVMPR-------------------MATLGLSFG------------------- 627

  Fly   671 VRELAAIIIALTIGFSNVIDMFFFVTFVR------TEHIVSESEFNVTASLESD----INLVVEG 725
               |.|.::.|.:.|.      |...|.|      |...:||       |:|:.    ::|||
  Rat   628 ---LVACLLGLVLSFC------FATEFSRCLPARSTLQAISE-------SVETQPLLRLSLVV-- 674

  Fly   726 MVTAEHLLPASFV----------EQ----------MRDAVPTERVLYPSYLSNFGVLILIAIAVI 770
             ||...||..:.:          ||          .|:.|.|...|.|.|..:. ||..||.:|.
  Rat   675 -VTVGSLLTVAIINMPLTFNPGPEQPGDNETSPLAARNRVGTPCELLPYYTCSC-VLGFIACSVF 737

  Fly   771 AQLTHLTKILLLLSIAALHCYFNIFIMQDLY-----ALEDDFEHQP--IISTRYAASG------- 821
            .:::...|.:||  ..||..|..:|.:...:     :.|.:..|:.  ::|...:.:.
  Rat   738 LRMSLELKAMLL--TVALVAYLLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGA 800

  Fly   822 -----------------------LLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQ 863
                                   :|..|.|.|  |:|.:|:..|:...||.:..::.|....|..
  Rat   801 QMTAPSPSSCLERDLKTMINFYLVLFYATLIL--LSRQIDYYCRLDCLWKKKFKKEHEEFETMEN 863

  Fly   864 RNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLR 928
            .|..|:.||||.|||.||:.:  ::.:|.|.|||..|.|:|||:|:|..||:|..||.:||||||
  Rat   864 VNRLLLENVLPAHVAAHFIGD--KAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLR 926

  Fly   929 FLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALE 993
            .|||:|:|||.||..|:|..:.||||||||||||:|::|.....|. .:..:..|:.:||||::.
  Rat   927 LLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHENQ-DLERKHVHIGVLVEFSMA 990

  Fly   994 LKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTE 1058
            |...|..||..|||.|.|::||||||:.|||||||||.||||||||||||||||||:.|.|||||
  Rat   991 LMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTE 1055

  Fly  1059 ETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            |||.||:..||:...|||:.|||||:|.|:::
  Rat  1056 ETCTILQGLGYSCECRGLINVKGKGELRTYFV 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	49/201 (24%)
		CYCc	256..453	CDD:214485	100/206 (49%)
		Guanylate_cyc	294..476	CDD:278633	96/213 (45%)
		CYCc	860..1071	CDD:214485	121/210 (58%)
		Guanylate_cyc	892..1092	CDD:278633	118/199 (59%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	59/237 (25%)
		Guanylate_cyc	272..422	CDD:306677	84/149 (56%)
		DUF1053	487..593	CDD:399378	25/146 (17%)
		Guanylate_cyc	891..1087	CDD:306677	118/196 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710