Protein Alignment Ac3 and Adcy2

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_112269.2
• Gene: Adcy2 / 81636
• RGDID: 619965
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1199
• Identity: 374/1199 - (31%)
• Similarity: 579/1199 - (48%)
• Gaps: 238/1199 - (19%)

  Fly    23 QTTSRRRQ--NDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI 85
            |...|||:  .|...|......|||..:  |...:.||.:|....::..|  .||...:
  Rat     3 QEAMRRRRYLRDRAEAAAAAAAGGGEGL--QRSRDWLYESYYCMSQQHPL--IVFLLLI------ 57

  Fly    86 GIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRAL----------- 139
                       |:..|:.|    |.....:|...:.      |...||.||.||
  Rat    58 -----------VMGACLAL----LAVFFALGLEVED------HVAFLITVPTALAIFFAIFILVC 101

  Fly   140 ----------------WLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL------I 182
                            |:..:....:::....:.|..|.:.:.:.:.|:||..||..:      .
  Rat   102 IESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIAS 166

  Fly   183 FLGLSIGCITYFICLSLPVG---YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFL 244
            .|..|...|...:.||...|   :..|      |:.||.::.....|.|..:..:.|...::.:.
  Rat   167 ILTSSSHTIVLSVYLSATPGAKEHLFW------QILANVIIFICGNLAGAYHKHLMELALQQTYR 225

  Fly   245 EAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSSSEA-----FKKIYMSRH 299
            :....::.::.:|.:..:|||||||:||.|:|::|:.::     |..:.:.     |..:|:.||
  Rat   226 DTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRH 290

  Fly   300 ENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDER 364
            .|||||||||||||.::|..|..:||.||||||.:||::|::.:.:|||||||||||:||.|...
  Rat   291 TNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 355

  Fly   365 PDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKM 429
            |:||..||.|||.|.:|||.|:......::||||:|:|.||.|::|.::||:||:|.||.|||.|
  Rat   356 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHM 420

  Fly   430 ESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI------------------ 476
            |:.|..||||||..||..|||.::||...||.|:..|:...:||||:
  Rat   421 EAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRH 485

  Fly   477 -------------TKVVKAFASPCAKKINETQAEIAHPNPNG--STTDIVSDEDDNDATLDDEEL 526
                         |:.::::.:  ||.........:....||  ||||:.
  Rat   486 TLDGAKMRASVRMTRYLESWGA--AKPFAHLHHRDSMTTENGKISTTDVP--------------- 533

  Fly   527 LAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTR-----DG---------HENLTKDTN 577
            :.|::..|             ..::.::.|:|.::||..|     ||         .|::.:
  Rat   534 MGQHNFQN-------------RTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQR--- 582

  Fly   578 IFLRFKNPQLEQLYAVYREPYSSLPLL------AALLVQCIDVLYSYLVLPRSTLHFINIAAPLV 636
            |.|.|.|..:|:.|..     ::||..      |.|:..||.:: ..||||::::...:..|..:
  Rat   583 ISLLFYNKNIEKEYRA-----TALPAFKYYVTCACLIFLCIFIV-QILVLPKTSILGFSFGAAFL 641

  Fly   637 PIAMLVVISLAESFSGMLPKFFVDVSKRFN-DITFVRELAAII-------IALTIGFSNVIDMFF 693
            .:..::.:    .|:|.|    :..||:.: .:.::.:.:.||       |:|||
  Rat   642 SLIFILFV----CFAGQL----LQCSKKASTSLMWLLKSSGIIANRPWPRISLTI---------- 688

  Fly   694 FVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVP--------TERV 750
                |.|..|::.:.||:.....|:           |..||.:.......:||        ...:
  Rat   689 ----VTTAIILTMAVFNMFFLSNSE-----------ETTLPTANTSNANVSVPDNQASILHARNL 738

  Fly   751 LYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDD----FEHQP 811
            .:..|.....:|.||:.:|..::.:..|:|:::  .||..|..|.:....:.|:..    |:...
  Rat   739 FFLPYFIYSCILGLISCSVFLRVNYELKMLIMM--VALVGYNTILLHTHAHVLDAYSQVLFQRPG 801

  Fly   812 I---ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVL 873
            |   :.|..:.|  |.:..:.|..|.|..::..|:.|.||.:..:::|....|...|..|:.|||
  Rat   802 IWKDLKTMGSVS--LSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVL 864

  Fly   874 PVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFD 938
            |.||||||:..:.: :::||.|||..|.|:|||:|:|.:||:|..||.:||||||.|||:|:|||
  Rat   865 PAHVAEHFLARSLK-NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFD 928

  Fly   939 ALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINE 1003
            .||..|:|..:.||||||||||||:|::...:..:......::.|:..:||||..|...|.:||:
  Rat   929 DLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINK 993

  Fly  1004 QSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFG 1068
            .|||.|.|::||||||:.||||||:||.||||||||||||||:|||....|||||||..||:..|
  Rat   994 HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLG 1058

  Fly  1069 YTFLQRGLVAVKGKGQLMTFYLQGKSQSS 1097
            ||...||::.|||||.|.|:::..:...|
  Rat  1059 YTCTCRGIINVKGKGDLKTYFVNTEMSRS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	133/378 (35%)
		Guanylate_cyc	294..476	CDD:425528	99/181 (55%)
		Guanylate_cyc	892..1092	CDD:425528	113/199 (57%)
Adcy2	NP_112269.2	AcyC	54..474	CDD:441717	148/452 (33%)
		Guanylate_cyc	285..469	CDD:425528	100/183 (55%)
		Adcy_cons_dom	499..604	CDD:461877	27/142 (19%)
		Guanylate_cyc	882..1081	CDD:425528	113/198 (57%)