DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Adcy5

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1163	Identity:	377/1163 - (32%)
Similarity:	600/1163 - (51%)	Gaps:	154/1163 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LENGQKTIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGGVVI-----------------LPQH 52
            ||.|..|:.....|          ....|.||.|   :|.|.|:                 .|..
  Rat   174 LEPGTGTVEDGDGS----------EDGGSSVASG---SGTGTVLSLGACCLALLQIFRSKKFPSD 225

  Fly    53 VLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQS-APTRVINCCMLLAYLALTALLHIG 116
            .|..||..|..:..:|.|.  :..|.|..:..:.:.:..: .|.:|:...:|.|  |:..:|.:.
  Rat   226 KLERLYQRYFFRLNQSSLT--MLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAA--AVGVILIMA 286

  Fly   117 RRSDKPALRRFHQIL----LIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTL 177
            ...::.|..:.|..|    ||.|..|:.::.:|      :.||. |..:.:.|.:...:.:|..|
  Rat   287 VLCNRAAFHQDHMGLACYALIAVVLAVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLL 344

  Fly   178 PLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRA 242
            |:::....|| |.:...:.|::.:..:..|..|..||.:|.::.:...::|:..::..|..|::|
  Rat   345 PVRMRAAVLS-GVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQA 408

  Fly   243 FLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILY 306
            |.|.::.::.::..:.::.:||||||||||:|||::|:.|:.:...: .|.|||:.:|:|||||:
  Rat   409 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILF 473

  Fly   307 ADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLC 371
            |||.|||:::|..:||:||..|||||||||:||.:...||||||||||||:||.|:.|.|||..|
  Rat   474 ADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC 538

  Fly   372 VHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAG 436
            |.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||||:|.||.|||.||:.||||
  Rat   539 VEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAG 603

  Fly   437 RVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHP 501
            |:||:..||.:|||::|||...|.:|...|:...::|:.|.:        |.:|..|.:|.||..
  Rat   604 RIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILR--------CTQKRKEEKAMIAKM 660

  Fly   502 NPNGSTT--------------------DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAV 542
            |...:.:                    :.||.|.......|.::..||.|.:...::    |.|:
  Rat   661 NRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAI 725

  Fly   543 TADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAAL 607
            .|...::::.|:.::.|                    |.|:.|.||:.|:...:......:..|.
  Rat   726 DARSIDRLRSEHVRKFL--------------------LTFREPDLEKKYSKQVDDRFGAYVACAS 770

  Fly   608 LVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVR 672
            ||..........::|.|........:..:.:|::|.||:..:...:.|.....:|::     .||
  Rat   771 LVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRK-----IVR 830

  Fly   673 E-----LAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHL 732
            .     |..:.....:..|..::||..            :..|:...|..:.|:.| ..|.|.|:
  Rat   831 SKKNSTLVGVFTITLVFLSAFVNMFMC------------NSKNLVGCLAEEHNITV-NQVNACHV 882

  Fly   733 LPASFVEQMRD-----AVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF 792
            :.::|...:.|     ..|.....:|.|.:...:|.|:|.:|..|::.:.|::|:|:|..::...
  Rat   883 MESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLI 947

  Fly   793 ------NIFIMQDLYALED--DF---------EHQPIISTRYAASGLLLVAALALSTLARHMDHE 840
                  .:|...||....:  ||         ||...::.:.....::.|..|||...|:.::..
  Rat   948 VEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVEST 1012

  Fly   841 DRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFA 905
            .|:.|.||.:..|:||...:::..|..|::|:||..||.||:...:| :|:||.||...|.|:||
  Rat  1013 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFA 1076

  Fly   906 SMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRT 970
            |:.|||:||.|...||:|:||||.|||:|:|||.::...:|:.:.||||||||||||||:
  Rat  1077 SIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL----- 1136

  Fly   971 VRNDAPITERW-SHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDI 1034
              ||:...:.. :|:..|.:||::|...::.|||.|||:|.:|:|:|.||:.|||||||||.|||
  Rat  1137 --NDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1199

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092
            |||||||||||:|||....||||.:...:|....|....||:|.|||||::||::|.|
  Rat  1200 WGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	44/161 (27%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	102/181 (56%)
		CYCc	860..1071	CDD:214485	106/211 (50%)
		Guanylate_cyc	892..1092	CDD:278633	106/200 (53%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	72/309 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196		7/31 (23%)
		Guanylate_cyc	461..634	CDD:306677	100/172 (58%)
		DUF1053	669..761	CDD:399378	18/111 (16%)
		Guanylate_cyc	1063..1257	CDD:306677	106/200 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710