Protein Alignment Ac3 and Adcy5

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1163
• Identity: 377/1163 - (32%)
• Similarity: 600/1163 - (51%)
• Gaps: 154/1163 - (13%)

  Fly     5 LENGQKTIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGGVVI-----------------LPQH 52
            ||.|..|:.....|          ....|.||.|   :|.|.|:                 .|..
  Rat   174 LEPGTGTVEDGDGS----------EDGGSSVASG---SGTGTVLSLGACCLALLQIFRSKKFPSD 225

  Fly    53 VLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQS-APTRVINCCMLLAYLALTALLHIG 116
            .|..||..|..:..:|.|.  :..|.|..:..:.:.:..: .|.:|:...:|.|  |:..:|.:.
  Rat   226 KLERLYQRYFFRLNQSSLT--MLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAA--AVGVILIMA 286

  Fly   117 RRSDKPALRRFHQIL----LIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTL 177
            ...::.|..:.|..|    ||.|..|:.::.:|      :.||. |..:.:.|.:...:.:|..|
  Rat   287 VLCNRAAFHQDHMGLACYALIAVVLAVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLL 344

  Fly   178 PLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRA 242
            |:::....|| |.:...:.|::.:..:..|..|..||.:|.::.:...::|:..::..|..|::|
  Rat   345 PVRMRAAVLS-GVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQA 408

  Fly   243 FLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILY 306
            |.|.::.::.::..:.::.:||||||||||:|||::|:.|:.:...: .|.|||:.:|:|||||:
  Rat   409 FQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILF 473

  Fly   307 ADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLC 371
            |||.|||:::|..:||:||..|||||||||:||.:...||||||||||||:||.|:.|.|||..|
  Rat   474 ADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC 538

  Fly   372 VHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAG 436
            |.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||||:|.||.|||.||:.||||
  Rat   539 VEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAG 603

  Fly   437 RVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHP 501
            |:||:..||.:|||::|||...|.:|...|:...::|:.|.:        |.:|..|.:|.||..
  Rat   604 RIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILR--------CTQKRKEEKAMIAKM 660

  Fly   502 NPNGSTT--------------------DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAV 542
            |...:.:                    :.||.|.......|.::..||.|.:...::    |.|:
  Rat   661 NRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAI 725

  Fly   543 TADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAAL 607
            .|...::::.|:.::.|                    |.|:.|.||:.|:...:......:..|.
  Rat   726 DARSIDRLRSEHVRKFL--------------------LTFREPDLEKKYSKQVDDRFGAYVACAS 770

  Fly   608 LVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVR 672
            ||..........::|.|........:..:.:|::|.||:..:...:.|.....:|::     .||
  Rat   771 LVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRK-----IVR 830

  Fly   673 E-----LAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHL 732
            .     |..:.....:..|..::||..            :..|:...|..:.|:.| ..|.|.|:
  Rat   831 SKKNSTLVGVFTITLVFLSAFVNMFMC------------NSKNLVGCLAEEHNITV-NQVNACHV 882

  Fly   733 LPASFVEQMRD-----AVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF 792
            :.::|...:.|     ..|.....:|.|.:...:|.|:|.:|..|::.:.|::|:|:|..::...
  Rat   883 MESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLI 947

  Fly   793 ------NIFIMQDLYALED--DF---------EHQPIISTRYAASGLLLVAALALSTLARHMDHE 840
                  .:|...||....:  ||         ||...::.:.....::.|..|||...|:.::..
  Rat   948 VEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVEST 1012

  Fly   841 DRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFA 905
            .|:.|.||.:..|:||...:::..|..|::|:||..||.||:...:| :|:||.||...|.|:||
  Rat  1013 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFA 1076

  Fly   906 SMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRT 970
            |:.|||:||.|...||:|:||||.|||:|:|||.::...:|:.:.||||||||||||||:
  Rat  1077 SIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL----- 1136

  Fly   971 VRNDAPITERW-SHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDI 1034
              ||:...:.. :|:..|.:||::|...::.|||.|||:|.:|:|:|.||:.|||||||||.|||
  Rat  1137 --NDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1199

  Fly  1035 WGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092
            |||||||||||:|||....||||.:...:|....|....||:|.|||||::||::|.|
  Rat  1200 WGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	143/337 (42%)
		Guanylate_cyc	294..476	CDD:425528	102/181 (56%)
		Guanylate_cyc	892..1092	CDD:425528	106/200 (53%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	72/309 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196		7/31 (23%)
		Guanylate_cyc	461..644	CDD:425528	102/182 (56%)
		Adcy_cons_dom	669..762	CDD:461877	18/112 (16%)
		Guanylate_cyc	1063..1257	CDD:425528	106/200 (53%)