Protein Alignment Ac3 and Adcy3

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_570135.2
• Gene: Adcy3 / 64508
• RGDID: 71009
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1169
• Identity: 450/1169 - (38%)
• Similarity: 647/1169 - (55%)
• Gaps: 152/1169 - (13%)

  Fly    33 SDVAGGVGIT-------GGGVVILPQHV--------LNELYHNYSIKQRRSGLKWFVFAAALFNI 82
            ||...|||.|       .|..:.||:.:        |..||..|..:||...|...|..||||:.
  Rat    26 SDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC 90

  Fly    83 WTIGI-----PWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLL 142
            :.:.:     ..|:.||..|....::|. :.|..|...|...|:.:.:        :||..||||
  Rat    91 YVVVMCAVVFSSDKLAPLMVAGVGLVLD-IILFVLCKKGLLPDRVSRK--------VVPYLLWLL 146

  Fly   143 SILHFTVYVILQPS--FSPRDLLGWAILLNFLVYVTLPLQL--IFLGLSIGCITYFICLSLPVGY 203
            .......|:.|..|  .:..|.:||.....|..::||||.|  |.:...:.|:.:.:.|.:.|..
  Rat   147 ITAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQ 211

  Fly   204 SHWDSL----LSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQE 264
            ...|.|    |..::.||..|...|.::|::.|:|.:.|.::|||||::||||||.:||||.:||
  Rat   212 QQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQE 276

  Fly   265 RLLLSVLPKHVAIKMREDLGSSSS----EAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLV 325
            .|:||:||||||.:|.:|:....|    :.|..:||.||||||||:|||||||.:||..|||:||
  Rat   277 NLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELV 341

  Fly   326 KMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKAN 390
            |:|||||||||:||.||.||||||||||||||.|.||.|.||||..:.|||:||:||.||::|..
  Rat   342 KLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTK 406

  Fly   391 SPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVE 455
            :.||||||:|||.||.|:|||::||:||:|.||.:|||||:.|..||||||..|:..|.|||:||
  Rat   407 TGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVE 471

  Fly   456 AAFGEKREELLRIAGLKTYFI---TKVVKAFA------------SPCAKKINETQAEIAHPN--- 502
            ...|..|.:.|...|::||.|   ...||..|            :|.:|..:....|...||
  Rat   472 PGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIETKEPNGSA 536

  Fly   503 -PNGSTTDIVSDED---DNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDEL 563
             .:|||::...:::   ||.:..:....|....:::.     .|.|.|:|    ....|.|.:.|
  Rat   537 HASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADR-----VVDASEDE----HELNQLLNEAL 592

  Fly   564 VTRDGHENLTKDTNIFL---RFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRST 625
            :.|:..: :.|..|.||   ||.:|::|..|:|.:|..|......:.:|.....:...|:.|...
  Rat   593 LERESAQ-VVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLM 656

  Fly   626 LHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVID 690
            .:::......|.:.:|.:.|:|..|....||..|..|...:...:.|...|::....:..:||:|
  Rat   657 TNYVTFVVGEVLLLILTICSMAAIFPRAFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVD 721

  Fly   691 MFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSY 755
            |...:.:..       ..:|||..:|.|                ...:|.            |.|
  Rat   722 MLSCLQYYM-------GPYNVTTGIELD----------------GGCMEN------------PKY 751

  Fly   756 LSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQ---------- 810
            .:...||.|||..::.|::|:.|:.|:|.:.......|::....::   |:::|:
  Rat   752 YNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVF---DEYDHKRFQEKDSPMV 813

  Fly   811 --------------------PIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQK 855
                                |::.::|:.:.::.|..|:....:||::...|.:|.||.||.:||
  Rat   814 ALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQK 878

  Fly   856 ETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVN 920
            |...:||:.|||||.|:||.|||.||:.:.||. ::||||||.|:||:|||:|||:|||:||::|
  Rat   879 ERVYEMRRWNEALVTNMLPEHVARHFLGSKKRD-EELYSQSYDEIGVMFASLPNFADFYTEESIN 942

  Fly   921 NQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGI-------NVQRTVRNDAPIT 978
            |.|:||||||||:|||||:||:.|:|:.|.||||||||||||||:       ....:.:.:....
  Rat   943 NGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDK 1007

  Fly   979 ERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVAS 1043
            |||.|||.|.:|||.:|..|.:||.||||:|:|::|:|.|.:.||||||||||||||||||||||
  Rat  1008 ERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVAS 1072

  Fly  1044 RMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVV 1107
            ||||||..|.|||.|||..|||.:|:.|::||.:.|||||:|:||:|:|:.:.:|.|..|.|.:
  Rat  1073 RMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTL 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	172/344 (50%)
		Guanylate_cyc	294..476	CDD:425528	117/181 (65%)
		Guanylate_cyc	892..1092	CDD:425528	129/206 (63%)
Adcy3	NP_570135.2	AcyC	105..499	CDD:441717	189/402 (47%)
		Guanylate_cyc	310..494	CDD:425528	118/183 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..563		10/58 (17%)
		Guanylate_cyc	914..1121	CDD:425528	129/206 (63%)